2005
Role of integrin α1β1 in the regulation of renal medullary osmolyte concentration
Moeckel GW, Zhang L, Chen X, Rossini M, Zent R, Pozzi A. Role of integrin α1β1 in the regulation of renal medullary osmolyte concentration. American Journal Of Physiology. Renal Physiology 2005, 290: f223-f231. PMID: 16106035, DOI: 10.1152/ajprenal.00371.2004.Peer-Reviewed Original ResearchConceptsIntegrin alpha1-null miceOsmolyte accumulationTonicity enhancer-binding proteinExtracellular matrix receptors integrinsOrganic osmolytesProtective organic osmolytesMEK inhibitor PD 98059Inositol uptakeInhibitor PD 98059Enhancer-binding proteinRenal medullary cellsTubular necrosisGene transcriptionOsmolyte transportersReceptor integrinPD 98059Altered signalingDifferent osmotic conditionsOsmolyte concentrationMammalian kidneyCell behaviorImportant mediatorERK1/2 phosphorylationOsmotic conditionsDuct cells
1997
Distribution of de novo synthesized betaine in rat kidney: role of renal synthesis on medullary betaine accumulation
Moeckel G, Lien Y. Distribution of de novo synthesized betaine in rat kidney: role of renal synthesis on medullary betaine accumulation. American Journal Of Physiology 1997, 272: f94-f99. PMID: 9039054, DOI: 10.1152/ajprenal.1997.272.1.f94.Peer-Reviewed Original ResearchConceptsRenal cortexMale Sprague-Dawley ratsSprague-Dawley ratsHepatic arteryRenal arteryRenal synthesisFurosemide diuresisPortal veinOxidase inhibitorsRat kidneyKidneyTotal urineMedullary concentrationUrine samplesMedullaMedullary cellsCortexArteryDe novo synthesisBetaine concentrationsMammalian kidneyWater deprivationDe novoMinNovo synthesis