Aldosterone stimulates fibronectin synthesis in renal fibroblasts through mineralocorticoid receptor-dependent and independent mechanisms
Chen D, Chen Z, Park C, Centrella M, McCarthy T, Chen L, Al-Omari A, Moeckel GW. Aldosterone stimulates fibronectin synthesis in renal fibroblasts through mineralocorticoid receptor-dependent and independent mechanisms. Gene 2013, 531: 23-30. PMID: 23994292, DOI: 10.1016/j.gene.2013.08.047.Peer-Reviewed Original ResearchConceptsProgression of fibrosisFibronectin synthesisChronic kidney diseaseC-Jun NH2-terminal protein kinaseMineralocorticoid hormone aldosteroneKidney fibroblast cell lineTranscription factor c-JunExtracellular signal-regulated kinaseReceptor-dependent activationSignal-regulated kinaseDependent signaling pathwaysKidney injuryInterstitial fibrosisKidney diseaseMineralocorticoid receptorHormone aldosteroneAldosteroneRenal fibroblastsAnimal modelsProtein kinaseFibroblast cell lineFibronectin expressionKidneyFibrosisSubsequent phosphorylation