2019
Development of a 2-dimensional atlas of the human kidney with imaging mass cytometry
Singh N, Avigan ZM, Kliegel JA, Shuch BM, Montgomery RR, Moeckel GW, Cantley LG. Development of a 2-dimensional atlas of the human kidney with imaging mass cytometry. JCI Insight 2019, 4: e129477. PMID: 31217358, PMCID: PMC6629112, DOI: 10.1172/jci.insight.129477.Peer-Reviewed Original ResearchConceptsCell typesIndividual cell typesCritical baseline dataRenal cell typesMass cytometryQuantitative atlasNormal human samplesHuman kidneyRelative abundanceDevelopment of therapiesHuman kidney diseaseKidney diseaseMetal-conjugated antibodiesQuantitative interrogationScarce samplesMachine-learning pipelineDiscovery purposesFuture quantitative analysisNovel abnormalityNormal human kidneySingle tissue sectionHuman samplesRenal biopsyImmune cellsCells
2014
Role of medullary progenitor cells in epithelial cell migration and proliferation
Chen D, Chen Z, Zhang Y, Park C, Al-Omari A, Moeckel GW. Role of medullary progenitor cells in epithelial cell migration and proliferation. American Journal Of Physiology. Renal Physiology 2014, 307: f64-f74. PMID: 24808539, PMCID: PMC4080159, DOI: 10.1152/ajprenal.00547.2013.Peer-Reviewed Original ResearchConceptsProgenitor cellsEpithelial cell migrationSide populationInterstitial cell lineEpithelial cellsBone marrow-derived stem cellsCell migrationMarrow-derived stem cellsInjury repairMedullary interstitiumDuct cellsInner medullaCell proliferationCell linesProliferationTubule formationStem cellsInterstitial progenitor cellsDifferentiation mediumCellsPhenotypic characteristicsCritical roleIMCD3 cellsPGE2CXCR4
2009
Urea promotes TonEBP expression and cellular adaptation in extreme hypertonicity
Kwon MS, Na KY, Moeckel G, Lee SD, Kwon HM. Urea promotes TonEBP expression and cellular adaptation in extreme hypertonicity. Pflügers Archiv - European Journal Of Physiology 2009, 459: 183. PMID: 19585141, DOI: 10.1007/s00424-009-0696-5.Peer-Reviewed Original ResearchConceptsCellular adaptationRegulation of TonEBPBody water homeostasisAmbient tonicityEpithelial cell lineCentral regulatorMDCK cellsTonEBPCellular proliferationWater homeostasisCell linesExpressionPrior adaptationInner medullaAdaptationRenal medullaAntidiuretic animalsHypertonicityRegulatorHomeostasisRegulationHigh levelsProliferationCellsModerate changes