Intrarenal Dopamine Inhibits Progression of Diabetic Nephropathy
Zhang MZ, Yao B, Yang S, Yang H, Wang S, Fan X, Yin H, Fogo AB, Moeckel GW, Harris RC. Intrarenal Dopamine Inhibits Progression of Diabetic Nephropathy. Diabetes 2012, 61: 2575-2584. PMID: 22688335, PMCID: PMC3447896, DOI: 10.2337/db12-0046.Peer-Reviewed Original ResearchConceptsIntrarenal dopaminergic systemRenal dopamine productionDopaminergic systemDopamine productionDiabetic nephropathyDiabetic miceWild-type diabetic miceOxidative stressDiabetic kidney injuryIntrarenal dopamine productionRenin-angiotensin systemMarkers of inflammationType 1 diabetesAromatic amino acid decarboxylaseCyclooxygenase-2 expressionKidney injuryRenal hemodynamicsRenal transplantationUnderlying pathogenesisDopamine metabolismInhibition of expressionInhibits progressionAmino acid decarboxylaseFluid reabsorptionKidney structure