2019
A Further Analysis and Commentary on: Profiling Changes in Cortical Astroglial Cells Following Chronic Stress
Coppola G, Rurak GM, Simard S, Salmaso N. A Further Analysis and Commentary on: Profiling Changes in Cortical Astroglial Cells Following Chronic Stress. Neuroscience Insights 2019, 13: 1179069519870182. PMID: 31452604, PMCID: PMC6698990, DOI: 10.1177/1179069519870182.Peer-Reviewed Original ResearchGene co-expression network analysisCo-expression network analysisAnxiety-like behaviorKey transcription factorPerineuronal netsAstroglial cellsExtracellular matrix componentsTrophic pathwaysImportant extracellular matrix componentTranscription factorsProtein degradationChronic stressNeuroplasticity hypothesisKey regulatorExpression of PNNsNeural plasticityCortical astroglial cellsChronic variable stressTreatment of depressionMatrix componentsMajor depressive disorderProfiling changesCortical neural plasticityKey mediatorModulates neuroplasticity
2018
Profiling changes in cortical astroglial cells following chronic stress
Simard S, Coppola G, Rudyk CA, Hayley S, McQuaid RJ, Salmaso N. Profiling changes in cortical astroglial cells following chronic stress. Neuropsychopharmacology 2018, 43: 1961-1971. PMID: 29907879, PMCID: PMC6046043, DOI: 10.1038/s41386-018-0105-x.Peer-Reviewed Original ResearchConceptsChronic variable stressDepressive-like behaviorPerineuronal netsAstroglial cellsAstroglial plasticityCortical astroglial cellsAstroglial cell functionModel of depressionAstroglial contributionNeuroplasticity hypothesisAstroglial changesCortical astrogliaAntidepressant potentialDepressive behaviorSwim testGFAP expressionDepressive phenotypeNeuronal plasticityGlutamate recyclingCorticosterone levelsRibosome affinity purificationSynaptic plasticityGrowth factor signalingChronic stressDegradation of PNNs