Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation
Freitas-Andrade M, Comin C, Van Dyken P, Ouellette J, Raman-Nair J, Blakeley N, Liu Q, Leclerc S, Pan Y, Liu Z, Carrier M, Thakur K, Savard A, Rurak G, Tremblay M, Salmaso N, da F. Costa L, Coppola G, Lacoste B. Astroglial Hmgb1 regulates postnatal astrocyte morphogenesis and cerebrovascular maturation. Nature Communications 2023, 14: 4965. PMID: 37587100, PMCID: PMC10432480, DOI: 10.1038/s41467-023-40682-3.Peer-Reviewed Original ResearchConceptsHigh mobility group box 1Blood-brain barrierGroup box 1Brain blood vesselsMouse cortical astrocytesPostnatal brain developmentAstroglial factorsNeurovascular couplingAstrocyte morphogenesisCortical astrocytesPostnatal weekAdult miceBox 1Aquaporin-4Endothelial ultrastructureAstrocyte morphologyNeuronal functionAstrocytesBrain developmentTranscriptional changesHMGB1Blood vesselsBirthAlters distributionImportant players