2024
Real-World Safety of Esketamine Nasal Spray: A Comprehensive Analysis of Esketamine and Respiratory Depression
Chepke C, Shelton R, Sanacora G, Doherty T, Tsytsik P, Parker N. Real-World Safety of Esketamine Nasal Spray: A Comprehensive Analysis of Esketamine and Respiratory Depression. The International Journal Of Neuropsychopharmacology 2024, pyae058. PMID: 39611487, DOI: 10.1093/ijnp/pyae058.Peer-Reviewed Original ResearchEsketamine nasal sprayRespiratory depressionAdverse eventsTreatment of treatment-resistant depressionStandardized Medical Dictionary for Regulatory ActivitiesPhase 3 clinical trialsTreatment-resistant depressionMitigation Strategy programCentral respiratory depressionTreatment of depressive symptomsAcute suicidal ideationPostdose observation periodNo adverse eventsMedical Dictionary for Regulatory ActivitiesOral antidepressantNasal sprayCases meeting criteriaDepressive disorderPostmarketing settingPostapproval dataSuicidal ideationDepressive symptomsOxygen saturationPulse oximetryCase definition
2023
Cognitive behavioral therapy following esketamine for major depression and suicidal ideation for relapse prevention: The CBT-ENDURE randomized clinical trial study protocol
Kitay B, Murphy E, Macaluso M, Corlett P, Hershenberg R, Joormann J, Martinez-Kaigi V, Nikayin S, Rhee T, Sanacora G, Shelton R, Thase M, Wilkinson S. Cognitive behavioral therapy following esketamine for major depression and suicidal ideation for relapse prevention: The CBT-ENDURE randomized clinical trial study protocol. Psychiatry Research 2023, 330: 115585. PMID: 37935086, DOI: 10.1016/j.psychres.2023.115585.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyMajor depressionSuicidal ideationRelapse preventionBehavioral therapyStudy protocolHigh riskClinical trial study protocolLong-term treatment approachKey secondary outcomesTrial study protocolHigh relapse rateHigh-risk populationSignificant suicidal ideationHospital dischargeSecondary outcomesPrimary outcomeRelapse rateFeasibility trialEsketamineTreatment approachesPatientsSuicide attemptsTherapySupplemental indications