2000
Kaposi's Sarcoma-Associated Herpesvirus Open Reading Frame 50/Rta Protein Activates the Entire Viral Lytic Cycle in the HH-B2 Primary Effusion Lymphoma Cell Line
Gradoville L, Gerlach J, Grogan E, Shedd D, Nikiforow S, Metroka C, Miller G. Kaposi's Sarcoma-Associated Herpesvirus Open Reading Frame 50/Rta Protein Activates the Entire Viral Lytic Cycle in the HH-B2 Primary Effusion Lymphoma Cell Line. Journal Of Virology 2000, 74: 6207-6212. PMID: 10846108, PMCID: PMC112123, DOI: 10.1128/jvi.74.13.6207-6212.2000.Peer-Reviewed Original Research
1992
Detection of Epstein‐Barr virus in the brain by the polymerase chain reaction
Pedneault L, Katz B, Miller G. Detection of Epstein‐Barr virus in the brain by the polymerase chain reaction. Annals Of Neurology 1992, 32: 184-192. PMID: 1324632, DOI: 10.1002/ana.410320210.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusEBV DNAPolymerase chain reactionRole of EBVChain reactionCentral nervous system syndromeDiverse neurological syndromesKidney transplant recipientsHerpes group virusesTransplant recipientsMetabolic encephalopathiesBrain biopsyImmunodeficiency syndromeNeurological syndromeImmunodeficient hostsEBV genomeBrain specimensViral isolationPatientsGroup virusesSerological testsSyndromeBrainVirusEncephalitis
1990
Differences in the extent of activation of Epstein-Barr virus replicative gene expression among four nonproducer cell lines stably transformed by OriP/BZLF1 plasmids
Gradoville L, Grogan E, Taylor N, Miller G. Differences in the extent of activation of Epstein-Barr virus replicative gene expression among four nonproducer cell lines stably transformed by OriP/BZLF1 plasmids. Virology 1990, 178: 345-354. PMID: 2171186, DOI: 10.1016/0042-6822(90)90331-k.Peer-Reviewed Original ResearchConceptsCell linesEffects of mutationsStable cell linesExtent of activationProtein functionCellular genesGene productsExtrachromosomal plasmidsGene expressionNonproducer cell linesExpression vectorEarly antigenEarly genesGenesLymphoid cell linesCellular subclonesEBV early genesReplicative gene expressionX50-7 cellsZEBRA proteinPlasmidZebraBZLF1 gene productLatent EBVEBV genesInhibition of specific binding of EBNA 1 to DNA by Murine Monoclonal and certain human polyclonal antibodies
Orlowski R, Polvino-Bodnar M, Hearing J, Miller G. Inhibition of specific binding of EBNA 1 to DNA by Murine Monoclonal and certain human polyclonal antibodies. Virology 1990, 176: 638-642. PMID: 2161154, DOI: 10.1016/0042-6822(90)90036-q.Peer-Reviewed Original ResearchConceptsEBNA-1 proteinGel mobility shift experimentsMobility shift experimentsSequence-specific DNARecognition of DNAEBNA-1Binding of DNASpecific bindingLac promoterDNA bindingMonoclonal antibodiesDimerization siteSpecific DNANonfusion proteinBurkitt's lymphoma cellsShift experimentsMolecular massEscherichia coliProteinDNASame monoclonal antibodyBindingPolyclonal antibodiesEB virusLymphoma cellsTopological Effects of EBNA 1 on oriP
Orlowski R, Miller G. Topological Effects of EBNA 1 on oriP. Advances In Experimental Medicine And Biology 1990, 278: 115-124. PMID: 1963028, DOI: 10.1007/978-1-4684-5853-4_12.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, MonoclonalAntigens, ViralBase SequenceBinding SitesDeoxyribonuclease IV (Phage T4-Induced)DNA, SuperhelicalDNA, ViralEndodeoxyribonucleasesEpstein-Barr Virus Nuclear AntigensEscherichia coliEscherichia coli ProteinsGenes, ViralHerpesvirus 4, HumanMolecular Sequence DataNucleic Acid ConformationPlasmidsRecombinant ProteinsRepetitive Sequences, Nucleic AcidTransformation, Bacterial
1988
Polymorphisms of the region of the Epstein-Barr virus genome which disrupts latency
Jenson H, Miller G. Polymorphisms of the region of the Epstein-Barr virus genome which disrupts latency. Virology 1988, 165: 549-564. PMID: 2841800, DOI: 10.1016/0042-6822(88)90599-5.Peer-Reviewed Original ResearchTHE FREQUENCY OF EPSTEIN-BARR VIRUS INFECTION AND ASSOCIATED LYMPHOPROLIFERATIVE SYNDROME AFTER TRANSPLANTATION AND ITS MANIFESTATIONS IN CHILDREN
Ho M, Jaffe R, Miller G, Breinig M, Dummer J, Makowka L, Atchison R, Karrer F, Nalesnik M, Starzl T. THE FREQUENCY OF EPSTEIN-BARR VIRUS INFECTION AND ASSOCIATED LYMPHOPROLIFERATIVE SYNDROME AFTER TRANSPLANTATION AND ITS MANIFESTATIONS IN CHILDREN. Transplantation 1988, 45: 719-726. PMID: 2833828, PMCID: PMC2993427, DOI: 10.1097/00007890-198804000-00011.Peer-Reviewed Original ResearchConceptsLymphoproliferative syndromePrimary infectionEBV infectionTransplant recipientsEpstein-Barr virus infectionMonoclonal B-cell lymphomaPediatric liver recipientsPrimary EBV infectionPediatric transplant recipientsEpstein-Barr virusEBV nuclear antigenB-cell lymphomaLiver recipientsPediatric EBVCyclosporine monitoringEBV DNAClinical typesPediatric casesSecond syndromeVirus infectionCell lymphomaAdditional casesGreater riskInfectionNuclear antigen
1986
Primary central nervous system lymphoma related to Epstein‐Barr virus in a patient with acquired immune deficiency syndrome
Rosenberg N, Hochberg F, Miller G, Kleinschmidt‐DeMasters B. Primary central nervous system lymphoma related to Epstein‐Barr virus in a patient with acquired immune deficiency syndrome. Annals Of Neurology 1986, 20: 98-102. PMID: 3017188, DOI: 10.1002/ana.410200118.Peer-Reviewed Original ResearchConceptsCentral nervous system lymphomaEpstein-Barr virus infectionNervous system lymphomaImmune deficiency syndromeSystem lymphomaDeficiency syndromeVirus infectionPrimary central nervous system lymphomaEpstein-Barr virus genomeEpstein-Barr virusCentral nervous systemPrimary lymphomaNervous systemTumor tissueLymphomaPatientsSyndromeInfectionAcid preparationsHybridization studiesDeoxyribonucleic acid preparationsVirus genomeK fragment
1985
Identification and expression of a nuclear antigen from the genomic region of the Jijoye strain of Epstein-Barr virus that is missing in its nonimmortalizing deletion mutant, P3HR-1.
Rowe D, Heston L, Metlay J, Miller G. Identification and expression of a nuclear antigen from the genomic region of the Jijoye strain of Epstein-Barr virus that is missing in its nonimmortalizing deletion mutant, P3HR-1. Proceedings Of The National Academy Of Sciences Of The United States Of America 1985, 82: 7429-7433. PMID: 2997790, PMCID: PMC391358, DOI: 10.1073/pnas.82.21.7429.Peer-Reviewed Original ResearchConceptsChronic active EBV infectionActive EBV infectionEpstein-Barr virusJijoye strainEBV infectionEBV DNACertain patientsP3HR-1Human antiseraVirus strainsNuclear antigenHr-1JijoyeVirus deletion mutantsLtk- cellsMouse Ltk- cellsImmortalization processPatientsGene transferNeoantigensLymphocytesInfectionAntigenAn identification of a transforming region of Epstein-Barr viral DNA cannot be confirmed
Miller G, Sugden B. An identification of a transforming region of Epstein-Barr viral DNA cannot be confirmed. Virology 1985, 143: 478-484. PMID: 2998023, DOI: 10.1016/0042-6822(85)90387-3.Peer-Reviewed Original Research
1984
Epstein-Barr virus with heterogeneous DNA disrupts latency
Miller G, Rabson M, Heston L. Epstein-Barr virus with heterogeneous DNA disrupts latency. Journal Of Virology 1984, 50: 174-182. PMID: 6321789, PMCID: PMC255597, DOI: 10.1128/jvi.50.1.174-182.1984.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusLatent Epstein-Barr virusEarly antigenRaji cellsViral synthesisX50-7 cellsHet DNABurkitt lymphoma linesActivated virusEBV DNANeonatal lymphocytesEBV replicationEBV sequencesX50-7Restriction endonuclease polymorphismAntigenLymphoma linesVirusRare variantsDefective virusLower ratesSuperinfectionCell spreadBiological effectsCellsRegions of the EBV genome involved in latency and lymphocyte immortalization.
Miller G. Regions of the EBV genome involved in latency and lymphocyte immortalization. Medical Virology 1984, 30: 107-28. PMID: 6087408.Peer-Reviewed Original ResearchAnimalsAntigens, ViralB-LymphocytesCell NucleusCell Transformation, ViralChildChild, PreschoolChromosome DeletionDNA, ViralEpstein-Barr Virus Nuclear AntigensFemaleGenes, ViralHerpesvirus 4, HumanHumansLymphomaMaleRepetitive Sequences, Nucleic AcidRNA, ViralTranscription, GeneticTumor Virus InfectionsVirionVirus Replication
1983
Identification of a rare Epstein-Barr virus variant that enhances early antigen expression in Raji cells.
Rabson M, Heston L, Miller G. Identification of a rare Epstein-Barr virus variant that enhances early antigen expression in Raji cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1983, 80: 2762-2766. PMID: 6302703, PMCID: PMC393908, DOI: 10.1073/pnas.80.9.2762.Peer-Reviewed Original Research
1982
New Epstein–Barr virus variants from cellular subclones of P3J-HR-1 Burkitt lymphoma
Heston L, Rabson M, Brown N, Miller G. New Epstein–Barr virus variants from cellular subclones of P3J-HR-1 Burkitt lymphoma. Nature 1982, 295: 160-163. PMID: 6276755, DOI: 10.1038/295160a0.Peer-Reviewed Original Research
1981
Copy number and location of Epstein-Barr viral genomes in neonatal human lymphocytes transformed after separation by size and treatment with mitogens
Anvret M, Miller G. Copy number and location of Epstein-Barr viral genomes in neonatal human lymphocytes transformed after separation by size and treatment with mitogens. Virology 1981, 111: 47-55. PMID: 6263010, DOI: 10.1016/0042-6822(81)90652-8.Peer-Reviewed Original ResearchConceptsNeonatal human lymphocytesEBV DNACell linesStaphylococcus aureusEpstein-Barr viral genomeHuman lymphocytesEBV DNA copiesEpstein-Barr virusPurified B lymphocytesFresh umbilical cordsB95-8 strainFicoll-Hypaque gradientDifferent cell linesEB virusMedian numberUmbilical cordB lymphocytesViral infectionViral genomeLymphocytesLipopolysaccharideSmall cell fractionPhysiologic stateTime of exposureCell fractionGenome of a mononucleosis epstein-barr virus contains DNA fragments previously regarded to be unique to Burkitt's lymphoma isolates
Fischer D, Miller G, Gradoville L, Heston L, Weststrate M, Maris W, Wright J, Brandsma J, Summers W. Genome of a mononucleosis epstein-barr virus contains DNA fragments previously regarded to be unique to Burkitt's lymphoma isolates. Cell 1981, 24: 543-553. PMID: 6263500, DOI: 10.1016/0092-8674(81)90345-7.Peer-Reviewed Original ResearchConceptsBurkitt's lymphomaB95-8Infectious mononucleosisUncomplicated infectious mononucleosisEpstein-Barr virusSalivary isolatesEBV infectionDisease manifestationsLymphomaMononucleosisPatientsEBVRestriction enzyme analysisVirusMajor insertionC fragmentEnzyme analysisHr-1IsolatesInfectionDeletionAvailable virusEpstein-Barr Viral DNA: Infectivity for Human Placental Cells
Miller G, Grogan E, Heston L, Robinson J, Smith D. Epstein-Barr Viral DNA: Infectivity for Human Placental Cells. Science 1981, 212: 452-455. PMID: 6259735, DOI: 10.1126/science.6259735.Peer-Reviewed Original Research
1974
Differences Between Laboratory Strains of Epstein-Barr Virus Based on Immortalization, Abortive Infection, and Interference
Miller G, Robinson J, Heston L, Lipman M. Differences Between Laboratory Strains of Epstein-Barr Virus Based on Immortalization, Abortive Infection, and Interference. Proceedings Of The National Academy Of Sciences Of The United States Of America 1974, 71: 4006-4010. PMID: 4372601, PMCID: PMC434316, DOI: 10.1073/pnas.71.10.4006.Peer-Reviewed Original ResearchConceptsEB virusEarly antigenH virusInitiation of immortalizationAntibody-negative human serumEpstein-Barr virusPretreatment of lymphocytesCell linesHuman umbilical cordDNA synthesisHuman serumInfectious mononucleosisCarrier cell linesBiologic behaviorB95-8Umbilical cordBurkitt's lymphomaLymphocyte immortalizationNonproducer cell linesHuman lymphocytesLaboratory strainsLymphocytesBiologic activityPrimary culturesAbortive infectionImmortalizing and nonimmortalizing laboratory strains of Epstein-Barr Virus.
Miller G, Robinson J, Heston L. Immortalizing and nonimmortalizing laboratory strains of Epstein-Barr Virus. Cold Spring Harbor Symposia On Quantitative Biology 1974, 39 Pt 2: 773-81. PMID: 169031, DOI: 10.1101/sqb.1974.039.01.089.Peer-Reviewed Original Research