2002
Revascularization alone (without mitral valve repair) suffices in patients with advanced ischemic cardiomyopathy and mild-to-moderate mitral regurgitation
Tolis GA, Korkolis DP, Kopf GS, Elefteriades JA. Revascularization alone (without mitral valve repair) suffices in patients with advanced ischemic cardiomyopathy and mild-to-moderate mitral regurgitation. The Annals Of Thoracic Surgery 2002, 74: 1476-1481. PMID: 12440595, DOI: 10.1016/s0003-4975(02)03927-9.Peer-Reviewed Original ResearchConceptsCongestive heart failureModerate mitral regurgitationMitral regurgitationLong-term survivalEjection fractionIschemic cardiomyopathyHeart failureCongestive heart failure classExcellent long-term survivalPreoperative congestive heart failureImproved left ventricular functionDegree of MRAdvanced ischemic cardiomyopathyHeart failure classCoronary artery bypassMean ejection fractionSevere mitral regurgitationLeft ventricular functionMitral valve operationsNumber of graftsEchocardiographic outcomesHospital mortalitySurgical revascularizationArtery bypassHeart transplantation
1998
Should Angiographically Disease-Free Saphenous Vein Grafts Be Replaced at the Time of Redo Coronary Artery Bypass Grafting?
Mehta I, Weinberg J, Jones M, Tellides G, Kopf G, Shaw R, Zaret B, Elefteriades J. Should Angiographically Disease-Free Saphenous Vein Grafts Be Replaced at the Time of Redo Coronary Artery Bypass Grafting? The Annals Of Thoracic Surgery 1998, 65: 17-23. PMID: 9456088, DOI: 10.1016/s0003-4975(97)01192-2.Peer-Reviewed Original ResearchConceptsSaphenous vein graftsVein graftsRedo CABGDisease-free graftsNR groupRedo Coronary Artery Bypass GraftingR groupCoronary Artery Bypass GraftingRedo coronary artery bypassGood late survivalArtery Bypass GraftingCoronary artery bypassLate myocardial infarctionFirst CABGRecurrent anginaRedo revascularizationArtery bypassBypass GraftingOperative mortalitySurgical mortalityAngiographic evaluationCardiac hospitalizationConsecutive patientsNew stenosisRandomized study
1987
Biological versus mechanical valves Analysis of 1,116 valves inserted in 1,012 adult patients with a 4,818 patient-year and a 5,327 valve-year follow-up
Hammond G, Geha A, Kopf G, Hashim S. Biological versus mechanical valves Analysis of 1,116 valves inserted in 1,012 adult patients with a 4,818 patient-year and a 5,327 valve-year follow-up. Journal Of Thoracic And Cardiovascular Surgery 1987, 93: 182-198. PMID: 3807394, DOI: 10.1016/s0022-5223(19)36440-2.Peer-Reviewed Original ResearchConceptsBiological valvesMechanical valvesPerivalvular leakValve failureMechanical prosthetic heart valvesYale-New Haven HospitalAnticoagulation-related hemorrhageLate cardiac deathValve-related mortalityValve-related deathIncidence of thromboembolismType of valveYears of ageProsthetic heart valvesAdult patientsTotal morbidityCardiac deathPatientsHeart valvesReoperationThromboembolismSignificant differencesValve analysisLittle direct evidenceYear period
1986
Bupivacaine for Intercostal Nerve Blocks in Children: Blood Concentrations and Pharmacokinetics.
Rothstein P, Arthur G, Feldman H, Kopf G, Covino B. Bupivacaine for Intercostal Nerve Blocks in Children: Blood Concentrations and Pharmacokinetics. Anesthesia & Analgesia 1986, 65: 625. PMID: 3706800, DOI: 10.1213/00000539-198606000-00011.Peer-Reviewed Original ResearchConceptsIntercostal nerve blockNerve blockBupivacaine concentrationsX minTotal body clearanceVolume of distributionPlasma concentration ratioSteady-state volumeBlood concentration valuesAdult patientsBody clearancePlasma concentrationsBlood concentrationsLocal anestheticsPharmacokinetic evaluationIntercostal spaceBupivacaine HClPharmacokinetic parametersApparent volumeAdditional groupHematocritBupivacaineChildrenClearanceAdultsFate of Left-Sided Cardiac Bioprosthesis Valves in Children
Kopf G, Geha A, Hellenbrand W, Kleinman C. Fate of Left-Sided Cardiac Bioprosthesis Valves in Children. JAMA Surgery 1986, 121: 488-490. PMID: 3954594, DOI: 10.1001/archsurg.1986.01400040126021.Peer-Reviewed Original ResearchConceptsEmergency valve replacementBioprosthetic valvesValve replacementMitral positionBioprosthetic valve failureMassive mitral regurgitationHigh operative mortalityPediatric age groupElective valve replacementYears of agePorcine bioprosthetic valvesLoss of mobilityLeaflet immobilityHospital mortalityOperative mortalityEmergency surgeryHemodynamic deteriorationMitral stenosisSevere calcificationMitral regurgitationBiologic valvesSevere stenosisThromboembolic phenomenaAortic positionMitral valveRepair of Aortic Coarctation in the First Three Months of Life: Immediate and Long-Term Results
Kopf G, Hellenbrand W, Kleinman C, Lister G, Talner N, Laks H. Repair of Aortic Coarctation in the First Three Months of Life: Immediate and Long-Term Results. The Annals Of Thoracic Surgery 1986, 41: 425-430. PMID: 3963920, DOI: 10.1016/s0003-4975(10)62701-4.Peer-Reviewed Original ResearchConceptsVentricular septal defectLong-term resultsNeonatal periodComplex congenital heart lesionsCongenital defectsIsolated ventricular septal defectMultiple ventricular septal defectsGroup IIIOptimum surgical procedurePrimary intracardiac repairPulmonary artery bandingRepair of coarctationGroup of patientsPatent ductus arteriosusLong-term outcomesTreatment of coarctationCongenital heart lesionsLow initial mortalityComplex congenital defectsComplex heart defectsMonths of ageFirst Three MonthsLate deathsRecurrent coarctationInitial hospitalization
1985
Measurement of central somatosensory conduction time in patients undergoing cardiopulmonary bypass: An index of neurologic function
Kopf G, Hume A, Durkin M, Hammond G, Hashim S, Geha A. Measurement of central somatosensory conduction time in patients undergoing cardiopulmonary bypass: An index of neurologic function. The American Journal Of Surgery 1985, 149: 445-448. PMID: 3985282, DOI: 10.1016/s0002-9610(85)80037-4.Peer-Reviewed Original ResearchConceptsSomatosensory conduction timeCentral conduction timeCentral somatosensory conduction timeOpen heart surgeryConduction timeCardiopulmonary bypassHeart surgeryCentral nervous system integrityNervous system integrityNeurologic functionProfound hypothermiaIntrapatient variabilityBypassSurgeryHypothermiaUseful indexDegrees C decreaseSomatosensoryPatientsAnesthesiaPredictors of outcome in early revascularization after acute myocardial infarction
Gertler J, Elefterlades J, Kopf G, Hashim S, Hammond G, Geha A. Predictors of outcome in early revascularization after acute myocardial infarction. The American Journal Of Surgery 1985, 149: 441-444. PMID: 3985281, DOI: 10.1016/s0002-9610(85)80036-2.Peer-Reviewed Original ResearchConceptsMyocardial infarctionAggressive medical therapyPoor ventricular functionAcute myocardial infarctionPredictors of outcomeTransmural myocardial infarctionEarly revascularizationMyocardial revascularizationConsecutive patientsMedical therapyVentricular damageVentricular functionInfarct extensionSubendocardial infarctionHigh riskInfarctionTransmural infarctsPatientsRevascularizationDays
1984
Noncardiogenic pulmonary edema after cardiopulmonary bypass An anaphylactic reaction to fresh frozen plasma
Hashim S, Kay H, Hammond G, Kopf G, Geha A. Noncardiogenic pulmonary edema after cardiopulmonary bypass An anaphylactic reaction to fresh frozen plasma. The American Journal Of Surgery 1984, 147: 560-564. PMID: 6711758, DOI: 10.1016/0002-9610(84)90022-9.Peer-Reviewed Original ResearchConceptsNoncardiogenic pulmonary edemaFresh frozen plasmaCardiac outputCardiopulmonary bypassPulmonary edemaFrozen plasmaWedge pressureAnaphylactic reactionsLeft-sided filling pressuresPulmonary artery diastolic pressurePulmonary capillary wedge pressureAdult respiratory distress syndromePositive end-expiratory pressureCapillary wedge pressureLow cardiac outputIntraaortic balloon pumpRespiratory distress syndromeAdministration of catecholaminesEnd-expiratory pressureSatisfactory cardiac outputNormal saline solutionAtrial pressureBalloon pumpDistress syndromeDiastolic pressureCombined valve replacement and myocardial revascularization
Geha A, Francis C, Hammond G, Laks H, Kopf G, Hashim S. Combined valve replacement and myocardial revascularization. Journal Of Vascular Surgery 1984, 1: 27-35. PMID: 6481868, DOI: 10.1016/0741-5214(84)90181-2.Peer-Reviewed Original ResearchConceptsAortic valve replacementMitral valve replacementOperative mortality rateValve replacementOperative deathsMitral regurgitationMortality rateSignificant concomitant diseasesActuarial survival rateCoronary artery bypassDegenerative mitral regurgitationIschemic mitral regurgitationArtery bypassConcomitant diseasesMyocardial revascularizationCoronary diseaseMitral replacementMitral operationsRheumatic diseasesMean ageOperative resultsCABGEarly deathPatientsSurvival rate
1983
Optimal methods of repair of descending thoracic aortic transections and aneurysms
Stavens B, Hashim S, Hammond G, Stansel H, Gatehouse J, Kopf G, Geha A. Optimal methods of repair of descending thoracic aortic transections and aneurysms. The American Journal Of Surgery 1983, 145: 508-513. PMID: 6837888, DOI: 10.1016/0002-9610(83)90049-1.Peer-Reviewed Original ResearchConceptsCross-clamp timeAverage cross-clamp timeGott shuntExtracorporeal circulationThoracic aortic transectionAcute transectionAortic transectionPostoperative bleedingAtherosclerotic aneurysmsTraumatic transectionConsecutive patientsSurgical repairFalse aneurysmSystemic heparinizationThoracic aortaSpinal cordHigh incidenceAcute disruptionSevere injuriesAneurysmsHigh mortalityPatientsTransectionShuntSafe method
1982
Changing patterns in the surgical management of ventricular septal rupture after myocardial infarction
Kopf G, Meshkov A, Laks H, Hammond G, Geha A. Changing patterns in the surgical management of ventricular septal rupture after myocardial infarction. The American Journal Of Surgery 1982, 143: 465-472. PMID: 7041671, DOI: 10.1016/0002-9610(82)90197-0.Peer-Reviewed Original ResearchConceptsVentricular septal rupturePostinfarction ventricular septal ruptureEarly surgical interventionSeptal ruptureSurgical interventionSevere cardiogenic shockUndue technical difficultyImportant prognostic indicatorYale-New Haven Medical CenterIntraaortic balloon pumpingCardiogenic shockOperable patientsHemodynamic deteriorationCardiac catheterizationConsecutive patientsHemodynamic supportBalloon pumpingOperable casesSurgical managementPulmonary arteryPrognostic indicatorModerate symptomsMyocardial infarctionFavorable outcomePharmacologic agents