Bupivacaine for Intercostal Nerve Blocks in Children: Blood Concentrations and Pharmacokinetics.
Rothstein P, Arthur G, Feldman H, Kopf G, Covino B. Bupivacaine for Intercostal Nerve Blocks in Children: Blood Concentrations and Pharmacokinetics. Anesthesia & Analgesia 1986, 65: 625. PMID: 3706800, DOI: 10.1213/00000539-198606000-00011.Peer-Reviewed Original ResearchMeSH KeywordsAbsorptionAdolescentAnesthesia, LocalBupivacaineChildChild, PreschoolDose-Response Relationship, DrugFemaleHalf-LifeHematocritHumansInfantInfusions, ParenteralIntercostal NervesKineticsMaleConceptsIntercostal nerve blockNerve blockBupivacaine concentrationsX minTotal body clearanceVolume of distributionPlasma concentration ratioSteady-state volumeBlood concentration valuesAdult patientsBody clearancePlasma concentrationsBlood concentrationsLocal anestheticsPharmacokinetic evaluationIntercostal spaceBupivacaine HClPharmacokinetic parametersApparent volumeAdditional groupHematocritBupivacaineChildrenClearanceAdults