1986
Bupivacaine for Intercostal Nerve Blocks in Children: Blood Concentrations and Pharmacokinetics.
Rothstein P, Arthur G, Feldman H, Kopf G, Covino B. Bupivacaine for Intercostal Nerve Blocks in Children: Blood Concentrations and Pharmacokinetics. Anesthesia & Analgesia 1986, 65: 625. PMID: 3706800, DOI: 10.1213/00000539-198606000-00011.Peer-Reviewed Original ResearchConceptsIntercostal nerve blockNerve blockBupivacaine concentrationsX minTotal body clearanceVolume of distributionPlasma concentration ratioSteady-state volumeBlood concentration valuesAdult patientsBody clearancePlasma concentrationsBlood concentrationsLocal anestheticsPharmacokinetic evaluationIntercostal spaceBupivacaine HClPharmacokinetic parametersApparent volumeAdditional groupHematocritBupivacaineChildrenClearanceAdultsFate of Left-Sided Cardiac Bioprosthesis Valves in Children
Kopf G, Geha A, Hellenbrand W, Kleinman C. Fate of Left-Sided Cardiac Bioprosthesis Valves in Children. JAMA Surgery 1986, 121: 488-490. PMID: 3954594, DOI: 10.1001/archsurg.1986.01400040126021.Peer-Reviewed Original ResearchConceptsEmergency valve replacementBioprosthetic valvesValve replacementMitral positionBioprosthetic valve failureMassive mitral regurgitationHigh operative mortalityPediatric age groupElective valve replacementYears of agePorcine bioprosthetic valvesLoss of mobilityLeaflet immobilityHospital mortalityOperative mortalityEmergency surgeryHemodynamic deteriorationMitral stenosisSevere calcificationMitral regurgitationBiologic valvesSevere stenosisThromboembolic phenomenaAortic positionMitral valve
1984
Noncardiogenic pulmonary edema after cardiopulmonary bypass An anaphylactic reaction to fresh frozen plasma
Hashim S, Kay H, Hammond G, Kopf G, Geha A. Noncardiogenic pulmonary edema after cardiopulmonary bypass An anaphylactic reaction to fresh frozen plasma. The American Journal Of Surgery 1984, 147: 560-564. PMID: 6711758, DOI: 10.1016/0002-9610(84)90022-9.Peer-Reviewed Original ResearchConceptsNoncardiogenic pulmonary edemaFresh frozen plasmaCardiac outputCardiopulmonary bypassPulmonary edemaFrozen plasmaWedge pressureAnaphylactic reactionsLeft-sided filling pressuresPulmonary artery diastolic pressurePulmonary capillary wedge pressureAdult respiratory distress syndromePositive end-expiratory pressureCapillary wedge pressureLow cardiac outputIntraaortic balloon pumpRespiratory distress syndromeAdministration of catecholaminesEnd-expiratory pressureSatisfactory cardiac outputNormal saline solutionAtrial pressureBalloon pumpDistress syndromeDiastolic pressure
1983
Optimal methods of repair of descending thoracic aortic transections and aneurysms
Stavens B, Hashim S, Hammond G, Stansel H, Gatehouse J, Kopf G, Geha A. Optimal methods of repair of descending thoracic aortic transections and aneurysms. The American Journal Of Surgery 1983, 145: 508-513. PMID: 6837888, DOI: 10.1016/0002-9610(83)90049-1.Peer-Reviewed Original ResearchConceptsCross-clamp timeAverage cross-clamp timeGott shuntExtracorporeal circulationThoracic aortic transectionAcute transectionAortic transectionPostoperative bleedingAtherosclerotic aneurysmsTraumatic transectionConsecutive patientsSurgical repairFalse aneurysmSystemic heparinizationThoracic aortaSpinal cordHigh incidenceAcute disruptionSevere injuriesAneurysmsHigh mortalityPatientsTransectionShuntSafe method