2023
Comparison of Percutaneous Interventional Ablation-Osteoplasty-Reinforcement-Internal Fixation (AORIF), Long Intramedullary Nailing, and Hemiarthroplasty for the Treatment of Focal Metastatic Osteolytic Lesions in the Femoral Head and Neck
Jiang W, Friedlaender G, Lindskog D, Latich I, Lee F. Comparison of Percutaneous Interventional Ablation-Osteoplasty-Reinforcement-Internal Fixation (AORIF), Long Intramedullary Nailing, and Hemiarthroplasty for the Treatment of Focal Metastatic Osteolytic Lesions in the Femoral Head and Neck. CardioVascular And Interventional Radiology 2023, 46: 649-657. PMID: 37052716, DOI: 10.1007/s00270-023-03425-x.Peer-Reviewed Original ResearchConceptsOsteolytic lesionsFemoral headSurgical complicationsRevision proceduresLong intramedullary nailingResultsSixty-seven patientsPost-operative complicationsEffective alternative treatmentTraditional surgical approachesAmbulatory scoreCombined painPrimary outcomeMedical complicationsMetastatic lesionsOncologic careRetrospective studyIntramedullary nailingSurgical approachFunction scoresNeck lesionsEarly improvementIM groupHemiarthroplastyComparative efficacyAlternative treatmentPercutaneous Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Pain and Ambulatory Function in Periacetabular Osteolytic Malignancies.
Dussik C, Toombs C, Alder K, Yu K, Berson E, Ibe I, Li F, Lindskog D, Friedlaender G, Latich I, Lee F. Percutaneous Ablation, Osteoplasty, Reinforcement, and Internal Fixation for Pain and Ambulatory Function in Periacetabular Osteolytic Malignancies. Radiology 2023, 307: e221401. PMID: 36916888, DOI: 10.1148/radiol.221401.Peer-Reviewed Original ResearchConceptsOsteolytic neoplasmAmbulatory functionInternal fixationEastern Cooperative Oncology Group scoreIndex scoreConversion hip arthroplastyRetrospective observational studySurgical site infectionKaplan-Meier analysisLong-term painQuality of lifeLong-term improvementWilcoxon signed-rank testNonambulatory patientsSecondary outcomesPrimary outcomeSite infectionOncologic careECOG scorePercutaneous ablationPeriacetabular metastasisProtrusio acetabuliFunctional improvementSigned-rank testClinical data
2020
Minimally Invasive Image-Guided Ablation, Osteoplasty, Reinforcement, and Internal Fixation (AORIF) for Osteolytic Lesions in the Pelvis and Periarticular Regions of Weight-Bearing Bones
Lee FY, Latich I, Toombs C, Mungur A, Conway D, Alder K, Ibe I, Lindskog D, Friedlaender G. Minimally Invasive Image-Guided Ablation, Osteoplasty, Reinforcement, and Internal Fixation (AORIF) for Osteolytic Lesions in the Pelvis and Periarticular Regions of Weight-Bearing Bones. Journal Of Vascular And Interventional Radiology 2020, 31: 649-658.e1. PMID: 32139256, DOI: 10.1016/j.jvir.2019.11.029.Peer-Reviewed Original ResearchMeSH KeywordsAblation TechniquesAdultAgedAged, 80 and overBone CementsBone NeoplasmsBone RemodelingBone ScrewsCalcaneusCementoplastyFemaleFemoral NeoplasmsFemurFracture Fixation, InternalHumansMaleMiddle AgedOsteolysisPelvic BonesPostoperative ComplicationsProspective StudiesRecovery of FunctionTibiaTime FactorsTreatment OutcomeWeight-BearingConceptsOsteolytic lesionsInternal fixationVisual analog scale pain scoreMusculoskeletal Tumor Society scoreProspective clinical cohort studyFunctional ambulation scoreOsteolytic skeletal lesionsPainful osteolytic lesionsScale pain scoresClinical cohort studyInvasive percutaneous approachWeight-bearing boneInternal fixation screwsBalloon osteoplastyPain scoresCohort studyProphylactic stabilizationSevere painSociety ScoreConsecutive patientsSurgical treatmentEarly outcomesTreatment optionsPercutaneous approachFunctional improvement
2016
Case of a Missed Giant Cell Tumor of Bone: An Opportunity to Observe its Natural History Disease.
Russo GS, Rubio DR, Yacob A, Lindskog DM, Alomari AK, Friedlaender GE. Case of a Missed Giant Cell Tumor of Bone: An Opportunity to Observe its Natural History Disease. Connecticut Medicine 2016, 80: 399-403. PMID: 29782126.Peer-Reviewed Case Reports and Technical NotesConceptsGiant cell tumorAnterior cruciate ligamentCell tumorsIncidental findingRoutine preoperative imagingPre-operative MRIInitial MRIPreoperative imagingSecond MRIMetaphyseal lesionsCruciate ligamentEnlarged massBenign neoplasmsRetrospective evaluationNatural historyTumorsYoung womenHistory diseaseMRIBoneLesionsPainPatientsNeoplasmsHistology
2001
Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions.
Friedlaender GE, Perry CR, Cole JD, Cook SD, Cierny G, Muschler GF, Zych GA, Calhoun JH, LaForte AJ, Yin S. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. Journal Of Bone And Joint Surgery 2001, 83-A Suppl 1: s151-8. PMID: 11314793, PMCID: PMC1425155, DOI: 10.2106/00004623-200100002-00010.Peer-Reviewed Original ResearchMeSH KeywordsAdultBone Morphogenetic Protein 7Bone Morphogenetic ProteinsBone TransplantationCollagenDrug CarriersDrug Delivery SystemsFemaleFracture Fixation, IntramedullaryFracture HealingFractures, UnunitedHumansMaleProspective StudiesRadiographyRecombinant ProteinsTibial FracturesTransforming Growth Factor betaConceptsTibial nonunionAdverse eventsRadiographic resultsClinical trialsOsteogenic protein-1Bone autograftAutogenous boneChronic donor site painAutograft-treated patientsFresh autogenous bonePlain radiographic evaluationMulti-center clinical trialPercent of patientsSeverity of painDonor site painGroup of patientsProtein 1Bone morphogenetic proteinNumerous animal modelsInvestigational device exemptionDonor site morbiditySame time pointsType ISite painClinical courseEvaluation of OP-1 as a Graft Substitute for Intertransverse Process Lumbar Fusion
Grauer J, Patel T, Erulkar J, Troiano N, Panjabi M, Friedlaender G. Evaluation of OP-1 as a Graft Substitute for Intertransverse Process Lumbar Fusion. Spine 2001, 26: 127-133. PMID: 11154530, DOI: 10.1097/00007632-200101150-00004.Peer-Reviewed Original ResearchConceptsIntertransverse process lumbar fusionIntertransverse process fusionManual palpationLumbar fusionOP-1Rabbit modelAutogenous iliac crest boneProcess fusionGraft substituteNew Zealand white rabbitsIliac crest boneOP-1 groupZealand white rabbitsMultidirectional flexibility testingAutograft specimensLess morbidityBiomechanical testing resultsCrest boneStudy groupAutograft groupBACKGROUND DATAFusion massWhite rabbitsL5-L6Bone graft substitute
1997
The Nicolas Andry Award-1995 Fracture Healing; Radiation Induced Alterations
Pelker R, Friedlaender G. The Nicolas Andry Award-1995 Fracture Healing; Radiation Induced Alterations. Clinical Orthopaedics And Related Research® 1997, 341: 267-282. PMID: 9269183, DOI: 10.1097/00003086-199708000-00038.Peer-Reviewed Original ResearchConceptsIncidence of fracturesNonunion of fracturesDose fractionation schemesRadiation-Induced AlterationsNicolas Andry AwardSingle doseFractionation schemeClinical observationsAllogeneic boneFracture healingIrradiated boneControl groupFinal repairIncidenceInduced alterationsRat femur modelNonunionDegree of delayFracturesImmature levelBoneRepairEffects of radiationAnimalsRefracture
1993
Effects of prefracture irradiation on the biomechanical parameters of fracture healing
Widmann R, Pelker R, Friedlaender G, Panjabi M, Peschel R. Effects of prefracture irradiation on the biomechanical parameters of fracture healing. Journal Of Orthopaedic Research® 1993, 11: 422-428. PMID: 8326449, DOI: 10.1002/jor.1100110315.Peer-Reviewed Original Research
1992
Bone graft and total hip arthroplasty A review
Huo M, Friedlaender G, Salvati E. Bone graft and total hip arthroplasty A review. The Journal Of Arthroplasty 1992, 7: 109-120. PMID: 1613516, DOI: 10.1016/0883-5403(92)90003-9.Peer-Reviewed Original Research
1991
Postfracture irradiation effects on the biomechanical and histologic parameters of fracture healing
Brown R, Pelker R, Friedlaender G, Peschel R, Panjabi M. Postfracture irradiation effects on the biomechanical and histologic parameters of fracture healing. Journal Of Orthopaedic Research® 1991, 9: 876-882. PMID: 1919851, DOI: 10.1002/jor.1100090614.Peer-Reviewed Original ResearchConceptsFracture healingControl fracturesDelay groupMature Sprague-Dawley ratsClosed femoral fracturesLong-term resultsSprague-Dawley ratsContralateral intact femurFemoral fracturesHistologic parametersLocal irradiationFracture repairFractured femurRadiation exposureWeeksIntact femurBiomechanical propertiesRatsDeleterious effectsShort-term deleterious effectsFemurDaysFracturesHealingGroupThe influence of ibuprofen on fracture repair: Biomechanical, biochemical, histologic, and histomorphometric parameters in rats
Huo M, Troiano N, Pelker R, Gundberg C, Friedlaender G. The influence of ibuprofen on fracture repair: Biomechanical, biochemical, histologic, and histomorphometric parameters in rats. Journal Of Orthopaedic Research® 1991, 9: 383-390. PMID: 2010842, DOI: 10.1002/jor.1100090310.Peer-Reviewed Original ResearchConceptsControl animalsHistomorphometric parametersFracture repairUnilateral femur fracturesMature Sprague-Dawley ratsSerum osteocalcin levelsCyclo-oxygenase inhibitorSprague-Dawley ratsBone formation rateInfluence of ibuprofenOral doseFemur fracturesOsteocalcin levelsClinical practiceBone volumeBone remodelingInhibitory effectSignificant alterationsFracture biomechanicsRatsAnimalsTail vertebraePresent studyIbuprofenRepair
1989
The effect of radiation on the fracture repair process. A biomechanical evaluation of a closed fracture in a rat model
Markbreiter L, Pelker R, Friedlaender G, Peschel R, Panjabi M. The effect of radiation on the fracture repair process. A biomechanical evaluation of a closed fracture in a rat model. Journal Of Orthopaedic Research® 1989, 7: 178-183. PMID: 2918417, DOI: 10.1002/jor.1100070204.Peer-Reviewed Original ResearchConceptsRat modelFemoral midshaft fractureBiomechanical parametersFracture repair processFracture healing processOpen fracture modelSingle doseMidshaft fracturesIntramedullary pinningClosed fracturesNormal controlsFracture healingControl groupNormal levelsSimilar fracturesBiomechanical evaluationHealing processExperimental groupWeeksFracturesRepair processTemporal progressionGroupEffects of radiationPrevious studies
1988
Angiosarcoma associated with foreign body material: A report of three cases
Jennings T, Peterson L, Axiotis C, Friedlaender G, Cooke R, Rosai J. Angiosarcoma associated with foreign body material: A report of three cases. Cancer 1988, 62: 2436-2444. PMID: 3052791, DOI: 10.1002/1097-0142(19881201)62:11<2436::aid-cncr2820621132>3.0.co;2-j.Peer-Reviewed Original Research
1986
Three‐dimensional load‐displacement curves due to froces on the cervical spine
Panjabi M, Summers D, Pelker R, Videman T, Friedlaender G, Southwick W. Three‐dimensional load‐displacement curves due to froces on the cervical spine. Journal Of Orthopaedic Research® 1986, 4: 152-161. PMID: 3712124, DOI: 10.1002/jor.1100040203.Peer-Reviewed Original Research
1985
Loose Body Within the Glenohumeral Joint in Recurrent Anterior Dislocation
Gould R, Rosenfield A, Friedlaender G. Loose Body Within the Glenohumeral Joint in Recurrent Anterior Dislocation. Journal Of Computer Assisted Tomography 1985, 9: 404-406. PMID: 3973177, DOI: 10.1097/00004728-198503000-00040.Peer-Reviewed Original ResearchEffects of short‐term Cyclosporin‐A on biomechanical properties of intact and fractured bone in the rat
Warren S, Pelker R, Friedlaender G. Effects of short‐term Cyclosporin‐A on biomechanical properties of intact and fractured bone in the rat. Journal Of Orthopaedic Research® 1985, 3: 96-100. PMID: 3981300, DOI: 10.1002/jor.1100030112.Peer-Reviewed Original ResearchConceptsControl animalsSolid organ allograft survivalFracture repairCurrent biomechanical dataOrgan allograft survivalShort-term cyclosporinBiomechanical propertiesSolid organ transplantationEffect of cyclosporinShort-term clinical useMidshaft femoral fractureNew immunosuppressant drugsAllograft survivalFemoral fracturesBone turnoverRat modelSkeletal toxicityOrgan transplantationSystemic effectsHistomorphometric studyImmunosuppressant drugsIntramedullary pinBiologic effectsFractured femurCyclosporinChemotherapy‐induced alterations in the biomechanics of rat bone
Pelker R, Friedlaender G, Panjabi M, Markham T, Hausman M, Doganis A, McKay J. Chemotherapy‐induced alterations in the biomechanics of rat bone. Journal Of Orthopaedic Research® 1985, 3: 91-95. PMID: 3981299, DOI: 10.1002/jor.1100030111.Peer-Reviewed Original Research
1984
Studies on the antigenicity of bone. II. Donor-specific anti-HLA antibodies in human recipients of freeze-dried allografts.
Friedlaender G, Strong D, Sell K. Studies on the antigenicity of bone. II. Donor-specific anti-HLA antibodies in human recipients of freeze-dried allografts. Journal Of Bone And Joint Surgery 1984, 66: 107-12. PMID: 6361041, DOI: 10.2106/00004623-198466010-00014.Peer-Reviewed Original ResearchConceptsDonor-specific anti-HLA antibodiesAnti-HLA antibodiesBone allograftImmune responseFreeze-dried bone allograftFreeze-dried allograftNinth patientAllograft donorsClinical eventsAllograftsPatientsHuman recipientsGraftAdverse effectsRecipientsAntibodiesMonthsBenign processSuch responsesResponseHLADonorsTissue types
1983
Biomechanical Properties of Bone Allografts
Pelker R, Friedlaender G, Markham T. Biomechanical Properties of Bone Allografts. Clinical Orthopaedics And Related Research® 1983, 174: 54-57. PMID: 6339144, DOI: 10.1097/00003086-198304000-00009.Peer-Reviewed Original ResearchConceptsOrthopaedic oncology serviceLow-grade tumorsPresence of recurrenceRelationship of complicationsMassachusetts General HospitalAllograft fractureOncology servicesAllograft implantationFunctional statusSkin sloughGeneral HospitalBone allograftIntramedullary rodFunctional restorationPatientsBenign conditionsResectionBone conditionsCadaveric segmentsComplicationsGraftBiomechanical propertiesTumorsMore yearsInfection
1981
Avascular necrosis of bone in Hodgkin's disease patients treated with combined modality therapy
Prosnitz L, Lawson J, Friedlaender G, Farber L, Pezzimenti J. Avascular necrosis of bone in Hodgkin's disease patients treated with combined modality therapy. Cancer 1981, 47: 2793-2797. PMID: 7260869, DOI: 10.1002/1097-0142(19810615)47:12<2793::aid-cncr2820471206>3.0.co;2-a.Peer-Reviewed Original ResearchConceptsAvascular necrosisHodgkin's diseaseModality therapyDisease patientsHumeral head involvementAdvanced Hodgkin's diseaseHodgkin's disease patientsLong-term survivorsBilateral hip replacementPossible serious consequencesNinth patientComplete remissionCorticosteroid administrationCumulative incidenceCombination chemotherapyHead involvementModality programConsiderable disabilityLarge dosesPatientsHip replacementFemoral headChemotherapeutic agentsNecrosisChemotherapy