The role of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in orthopaedic bone repair and regeneration.
Friedlaender GE, Lin S, Solchaga LA, Snel LB, Lynch SE. The role of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in orthopaedic bone repair and regeneration. Current Pharmaceutical Design 2013, 19: 3384-90. PMID: 23432673, DOI: 10.2174/1381612811319190005.Peer-Reviewed Original ResearchConceptsRecombinant human platelet-derived growth factor-BBClinical studiesMesenchymal stem cellsRecombinant human PDGFStrong mitogenic factorHuman platelet-derived growth factor-BBPlatelet-derived growth factor-BBPivotal clinical studiesImproved safety profileTissue repairGrowth factor-BBMechanism of actionDiabetic patientsChronic footSafety profileAnkle fusionPeriodontal diseaseChronic infectionClinical developmentSoft tissue repairAlveolar boneBone autograftHuman PDGFMitogenic factorFactor-BB