2020
Bone Scans Have Little Utility in the Evaluation of Well-Differentiated Cartilaginous Lesions of the Humerus.
Samuel AM, Munger AM, Lee FY, Friedlaender GE, Ibe IK, Lindskog DM. Bone Scans Have Little Utility in the Evaluation of Well-Differentiated Cartilaginous Lesions of the Humerus. Orthopedics 2020, 43: e498-e502. PMID: 32882054, DOI: 10.3928/01477447-20200827-05.Peer-Reviewed Original ResearchConceptsRadionuclide bone scanBone scanMRI scansPositive findingsNegative findingsMagnetic resonance imaging (MRI) scansBone scan findingsProgression of lesionsResonance imaging scansDiagnosis of enchondromaAcademic medical centerBivariate logistic regressionAssociation of boneScan findingsAggressive featuresRadiographic findingsEndosteal scallopingBenign enchondromaImaging scansMedical recordsMedical CenterMalignant lesionsCartilaginous lesionsEnchondromaPatientsMinimally Invasive Image-Guided Ablation, Osteoplasty, Reinforcement, and Internal Fixation (AORIF) for Osteolytic Lesions in the Pelvis and Periarticular Regions of Weight-Bearing Bones
Lee FY, Latich I, Toombs C, Mungur A, Conway D, Alder K, Ibe I, Lindskog D, Friedlaender G. Minimally Invasive Image-Guided Ablation, Osteoplasty, Reinforcement, and Internal Fixation (AORIF) for Osteolytic Lesions in the Pelvis and Periarticular Regions of Weight-Bearing Bones. Journal Of Vascular And Interventional Radiology 2020, 31: 649-658.e1. PMID: 32139256, DOI: 10.1016/j.jvir.2019.11.029.Peer-Reviewed Original ResearchMeSH KeywordsAblation TechniquesAdultAgedAged, 80 and overBone CementsBone NeoplasmsBone RemodelingBone ScrewsCalcaneusCementoplastyFemaleFemoral NeoplasmsFemurFracture Fixation, InternalHumansMaleMiddle AgedOsteolysisPelvic BonesPostoperative ComplicationsProspective StudiesRecovery of FunctionTibiaTime FactorsTreatment OutcomeWeight-BearingConceptsOsteolytic lesionsInternal fixationVisual analog scale pain scoreMusculoskeletal Tumor Society scoreProspective clinical cohort studyFunctional ambulation scoreOsteolytic skeletal lesionsPainful osteolytic lesionsScale pain scoresClinical cohort studyInvasive percutaneous approachWeight-bearing boneInternal fixation screwsBalloon osteoplastyPain scoresCohort studyProphylactic stabilizationSevere painSociety ScoreConsecutive patientsSurgical treatmentEarly outcomesTreatment optionsPercutaneous approachFunctional improvement
2003
Malignant bone tumors: limb sparing versus amputation.
DiCaprio MR, Friedlaender GE. Malignant bone tumors: limb sparing versus amputation. Journal Of The American Academy Of Orthopaedic Surgeons 2003, 11: 25-37. PMID: 12699369, DOI: 10.5435/00124635-200301000-00005.Peer-Reviewed Original ResearchConceptsLimb-sparing proceduresAppropriate surgical alternativesFunctional outcome studiesMainstay of treatmentExtent of diseaseAllograft-prosthetic compositeMalignant bone tumorsImportant outcome measureEffective chemotherapeutic agentLimb sparingMost patientsPatient ageReconstructed limbExpandable prosthesisSurgical alternativeTumor locationBone tumorsReconstructive surgeryOutcome measuresOutcome studiesSatisfactory functionModular endoprosthesesSurvival rateBone graftChemotherapeutic agents
1987
Allogeneic Bone in the Treatment of Tumors, Trauma, and Congenital Anomalies of the Hand
Trumble T, Friedlaender G. Allogeneic Bone in the Treatment of Tumors, Trauma, and Congenital Anomalies of the Hand. Orthopedic Clinics Of North America 1987, 18: 301-310. PMID: 3550577, DOI: 10.1016/s0030-5898(20)30393-x.Peer-Reviewed Original ResearchConceptsAllogeneic boneBone graftEarly motionAutogenous corticocancellous graftCongruent joint surfaceLarge osteochondral allograftsShorter hospital stayDonor site deficitMassive bone graftGraft donor sitesTubular graftSmall bone graftStrong cortical boneDonor siteAutogenous bone graftDonor site morbidityTreatment of tumorsHospital stayCortical graftsPediatric patientsFibular headHand therapyCorticocancellous graftHand injuriesInternal fixation
1984
Transplantation of Osteochondral Allografts
Friedlaender G, Mankin H. Transplantation of Osteochondral Allografts. Annual Review Of Medicine 1984, 35: 311-324. PMID: 6372659, DOI: 10.1146/annurev.me.35.020184.001523.Peer-Reviewed Original ResearchConceptsOsteochondral allograftsMassive osteochondral allograftsExcellent clinical resultsLimb-sparing approachesClinical resultsSkeletal deficitsBone tumorsImmune responseNeoplastic disordersCartilage graftsAllograftsSatisfactory tissueGraftEffective boneTransplantationLesionsTumorsInfectionAntigenBiological significance
1983
Biomechanical Properties of Bone Allografts
Pelker R, Friedlaender G, Markham T. Biomechanical Properties of Bone Allografts. Clinical Orthopaedics And Related Research® 1983, 174: 54-57. PMID: 6339144, DOI: 10.1097/00003086-198304000-00009.Peer-Reviewed Original ResearchConceptsOrthopaedic oncology serviceLow-grade tumorsPresence of recurrenceRelationship of complicationsMassachusetts General HospitalAllograft fractureOncology servicesAllograft implantationFunctional statusSkin sloughGeneral HospitalBone allograftIntramedullary rodFunctional restorationPatientsBenign conditionsResectionBone conditionsCadaveric segmentsComplicationsGraftBiomechanical propertiesTumorsMore yearsInfection
1975
A laboratory model for the study of the immunobiology of osteosarcoma
Friedlaender G, Mitchell M. A laboratory model for the study of the immunobiology of osteosarcoma. Cancer 1975, 36: 1631-1639. PMID: 172215, DOI: 10.1002/1097-0142(197511)36:5<1631::aid-cncr2820360516>3.0.co;2-w.Peer-Reviewed Original ResearchConceptsCell-mediated immunityRegression of diseaseWistar-Lewis ratsMoloney sarcomasMoloney sarcoma virusProgressive diseaseClinical courseLung metastasesMicrocytotoxicity assayTreatment protocolImmune responseImmunologic similaritiesHuman osteosarcomaSerum factorsTumor cellsMarrow cavityOsteosarcomaTarget cellsRatsTumorsDiseaseSarcoma virusAnimalsWeeks of inoculationTissue culture