1993
Effects of prefracture irradiation on the biomechanical parameters of fracture healing
Widmann R, Pelker R, Friedlaender G, Panjabi M, Peschel R. Effects of prefracture irradiation on the biomechanical parameters of fracture healing. Journal Of Orthopaedic Research® 1993, 11: 422-428. PMID: 8326449, DOI: 10.1002/jor.1100110315.Peer-Reviewed Original Research
1991
Postfracture irradiation effects on the biomechanical and histologic parameters of fracture healing
Brown R, Pelker R, Friedlaender G, Peschel R, Panjabi M. Postfracture irradiation effects on the biomechanical and histologic parameters of fracture healing. Journal Of Orthopaedic Research® 1991, 9: 876-882. PMID: 1919851, DOI: 10.1002/jor.1100090614.Peer-Reviewed Original ResearchConceptsFracture healingControl fracturesDelay groupMature Sprague-Dawley ratsClosed femoral fracturesLong-term resultsSprague-Dawley ratsContralateral intact femurFemoral fracturesHistologic parametersLocal irradiationFracture repairFractured femurRadiation exposureWeeksIntact femurBiomechanical propertiesRatsDeleterious effectsShort-term deleterious effectsFemurDaysFracturesHealingGroupThe influence of ibuprofen on fracture repair: Biomechanical, biochemical, histologic, and histomorphometric parameters in rats
Huo M, Troiano N, Pelker R, Gundberg C, Friedlaender G. The influence of ibuprofen on fracture repair: Biomechanical, biochemical, histologic, and histomorphometric parameters in rats. Journal Of Orthopaedic Research® 1991, 9: 383-390. PMID: 2010842, DOI: 10.1002/jor.1100090310.Peer-Reviewed Original ResearchConceptsControl animalsHistomorphometric parametersFracture repairUnilateral femur fracturesMature Sprague-Dawley ratsSerum osteocalcin levelsCyclo-oxygenase inhibitorSprague-Dawley ratsBone formation rateInfluence of ibuprofenOral doseFemur fracturesOsteocalcin levelsClinical practiceBone volumeBone remodelingInhibitory effectSignificant alterationsFracture biomechanicsRatsAnimalsTail vertebraePresent studyIbuprofenRepair
1989
Allograft incorporation: A biomechanical evaluation in a rat model
Pelker R, McKay J, Troiano N, Panjabi M, Friedlaender G. Allograft incorporation: A biomechanical evaluation in a rat model. Journal Of Orthopaedic Research® 1989, 7: 585-589. PMID: 2786956, DOI: 10.1002/jor.1100070417.Peer-Reviewed Original ResearchConceptsLewis ratsLevel of freezingImmunologic responseSprague-Dawley rat femursRat modelImmune responseAllogeneic boneFresh allograftsOsteosynthesis siteBiomechanical evaluationBiomechanical testingBiologic responseSubsequent healingAllograftsRat femurRatsIntact boneBoneFemurSignificant levelsResponseTransplantationTransplantGraftWeeksThe effect of radiation on the fracture repair process. A biomechanical evaluation of a closed fracture in a rat model
Markbreiter L, Pelker R, Friedlaender G, Peschel R, Panjabi M. The effect of radiation on the fracture repair process. A biomechanical evaluation of a closed fracture in a rat model. Journal Of Orthopaedic Research® 1989, 7: 178-183. PMID: 2918417, DOI: 10.1002/jor.1100070204.Peer-Reviewed Original ResearchConceptsRat modelFemoral midshaft fractureBiomechanical parametersFracture repair processFracture healing processOpen fracture modelSingle doseMidshaft fracturesIntramedullary pinningClosed fracturesNormal controlsFracture healingControl groupNormal levelsSimilar fracturesBiomechanical evaluationHealing processExperimental groupWeeksFracturesRepair processTemporal progressionGroupEffects of radiationPrevious studies
1987
Biomechanical Aspects of Bone Autografts and Allografts
Pelker R, Friedlaender G. Biomechanical Aspects of Bone Autografts and Allografts. Orthopedic Clinics Of North America 1987, 18: 235-239. PMID: 3561975, DOI: 10.1016/s0030-5898(20)30387-4.Peer-Reviewed Original ResearchConceptsMechanical propertiesLarge torsional loadsLocal biomechanical environmentCompressive loadTorsional loadsFreeze-dried graftsFreeze-dried boneMechanical issuesBiomechanical responseLoadBiomechanical environmentBiomechanical aspectsBiomechanical perspectivePropertiesNormal biomechanicsFixation devicesBone graftDonor boneDevicesFrozen boneSkeletal reconstruction
1985
Effects of short‐term Cyclosporin‐A on biomechanical properties of intact and fractured bone in the rat
Warren S, Pelker R, Friedlaender G. Effects of short‐term Cyclosporin‐A on biomechanical properties of intact and fractured bone in the rat. Journal Of Orthopaedic Research® 1985, 3: 96-100. PMID: 3981300, DOI: 10.1002/jor.1100030112.Peer-Reviewed Original ResearchConceptsControl animalsSolid organ allograft survivalFracture repairCurrent biomechanical dataOrgan allograft survivalShort-term cyclosporinBiomechanical propertiesSolid organ transplantationEffect of cyclosporinShort-term clinical useMidshaft femoral fractureNew immunosuppressant drugsAllograft survivalFemoral fracturesBone turnoverRat modelSkeletal toxicityOrgan transplantationSystemic effectsHistomorphometric studyImmunosuppressant drugsIntramedullary pinBiologic effectsFractured femurCyclosporinChemotherapy‐induced alterations in the biomechanics of rat bone
Pelker R, Friedlaender G, Panjabi M, Markham T, Hausman M, Doganis A, McKay J. Chemotherapy‐induced alterations in the biomechanics of rat bone. Journal Of Orthopaedic Research® 1985, 3: 91-95. PMID: 3981299, DOI: 10.1002/jor.1100030111.Peer-Reviewed Original Research
1984
Radiation‐induced alterations of fracture healing biomechanics
Pelker R, Friedlaender G, Panjabi M, Kapp D, Doganis A. Radiation‐induced alterations of fracture healing biomechanics. Journal Of Orthopaedic Research® 1984, 2: 90-96. PMID: 6491804, DOI: 10.1002/jor.1100020114.Peer-Reviewed Original Research
1983
Biomechanical Properties of Bone Allografts
Pelker R, Friedlaender G, Markham T. Biomechanical Properties of Bone Allografts. Clinical Orthopaedics And Related Research® 1983, 174: 54-57. PMID: 6339144, DOI: 10.1097/00003086-198304000-00009.Peer-Reviewed Original ResearchConceptsOrthopaedic oncology serviceLow-grade tumorsPresence of recurrenceRelationship of complicationsMassachusetts General HospitalAllograft fractureOncology servicesAllograft implantationFunctional statusSkin sloughGeneral HospitalBone allograftIntramedullary rodFunctional restorationPatientsBenign conditionsResectionBone conditionsCadaveric segmentsComplicationsGraftBiomechanical propertiesTumorsMore yearsInfection
1978
Clinical Evaluation of Freezedried Bone Allografts in Periodontal Osseous Defects‐Part II
Sepe W, Bowers G, Lawrence J, Friedlaender G, Koch R. Clinical Evaluation of Freezedried Bone Allografts in Periodontal Osseous Defects‐Part II. The Journal Of Periodontology 1978, 49: 9-14. PMID: 340637, DOI: 10.1902/jop.1978.49.1.9.Peer-Reviewed Original Research
1976
The use of freeze-dried bone in middle-third face advancements
Epker B, Friedlaender G, Wolford L, West R. The use of freeze-dried bone in middle-third face advancements. Oral Surgery Oral Medicine Oral Pathology And Oral Radiology 1976, 42: 278-289. PMID: 787861, DOI: 10.1016/0030-4220(76)90161-4.Peer-Reviewed Original ResearchConceptsFreeze-dried bone allograftPrimary operative procedureFreeze-dried boneMedical Research InstituteNaval Medical Research InstituteSmall sequestrumAdditional surgeryOperative procedureClinical infectionBone allograftPatientsMaxillary areaAutogenous boneGraft materialInfectionTissue banksIntraoral exposureAllograftsBoneGraftMorbiditySequestrumComplicationsSurgeryOsteotomy