Effects of chemotherapeutic agents on bone. I. Short-term methotrexate and doxorubicin (adriamycin) treatment in a rat model.
Friedlaender G, Tross R, Doganis A, Kirkwood J, Baron R. Effects of chemotherapeutic agents on bone. I. Short-term methotrexate and doxorubicin (adriamycin) treatment in a rat model. Journal Of Bone And Joint Surgery 1984, 66: 602-7. PMID: 6707039, DOI: 10.2106/00004623-198466040-00016.Peer-Reviewed Original ResearchConceptsChemotherapeutic agentsShort-term methotrexateThickness of osteoidShort-term administrationTrabecular bone volumeNumber of osteoclastsPhysiological bone turnoverWistar-Lewis ratsBone formation rateTotal bone massBone allograft incorporationRate of resorptionChronic treatmentBone turnoverNew bone formationTherapeutic dosesBone massUntreated ratsRat modelBone allograftBone volumeProximal tail vertebraeOsteoblastic activityDoxorubicin treatmentAdverse effects