2018
Immuno-oncologic Approach to Musculoskeletal Tumors
Ibe I, Sahlstrom A, Nguyen M, Lindskog D, Friedlaender G, Lee F. Immuno-oncologic Approach to Musculoskeletal Tumors. Techniques In Orthopaedics 2018, 33: 140-147. DOI: 10.1097/bto.0000000000000305.Peer-Reviewed Original ResearchImmune systemImmuno-oncologic therapiesSoft tissue sarcomasHost immune surveillanceActive immune responseTreatment of boneImmune therapyTumor burdenTissue sarcomasTreatment of cancerTreatment optionsMusculoskeletal tumorsComprehensive careImproved outcomesImmune surveillanceImmune responseOrthopedic oncologyMalignant cellsImmunotherapyCancer cellsPrecision medicineDistant sitesPatientsUnderlying mechanismTherapy
1999
LONG-TERM FOLLOW-UP OF PATIENTS WITH OSTEOCHONDRAL ALLOGRAFTS A Correlation Between Immunologic Responses and Clinical Outcome
Friedlaender G, Strong D, Tomford W, Mankin H. LONG-TERM FOLLOW-UP OF PATIENTS WITH OSTEOCHONDRAL ALLOGRAFTS A Correlation Between Immunologic Responses and Clinical Outcome. Orthopedic Clinics Of North America 1999, 30: 583-588. PMID: 10471763, DOI: 10.1016/s0030-5898(05)70111-5.Peer-Reviewed Original ResearchConceptsClinical outcomesImmunologic responseHistocompatibility antigensLong-term clinical outcomesLong-term resultsFrozen bone allograftsPresence of sensitizationFrozen osteochondral allograftsImmune responseBone allograftAnimal modelsSatisfactory outcomeOsteochondral allograftsReconstructive alternativeClass IIBiologic successAllograftsOutcomesAntigenResponsePatientsHumansSensitization
1992
Immune responses to osteochondral allografts: nature and significance.
Friedlaender G, Horowitz M. Immune responses to osteochondral allografts: nature and significance. Orthopedics 1992, 15: 1171-5. PMID: 1409127, DOI: 10.3928/0147-7447-19921001-08.Peer-Reviewed Original ResearchConceptsImmune responseOsteochondral allograftsSuppressor/cytotoxic phenotypeBiologic significanceNumerous animal modelsT cell activationCell surface antigensMajor histocompatibility complexClinical resultsCytotoxic phenotypeBone allograftAnimal modelsSurface antigenBone graftAllograftsBiologic outcomesHistocompatibility complexCellular elementsGraftAntigenResponseImmunogenicitySignificance
1991
Induction of specific T-cell responsiveness to allogeneic bone.
Horowitz M, Friedlaender G. Induction of specific T-cell responsiveness to allogeneic bone. Journal Of Bone And Joint Surgery 1991, 73: 1157-68. PMID: 1716256, DOI: 10.2106/00004623-199173080-00004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, Differentiation, T-LymphocyteBone and BonesBone MarrowBone TransplantationCells, CulturedCytotoxicity Tests, ImmunologicEpitopesLymphocyte ActivationLymphocyte Culture Test, MixedMajor Histocompatibility ComplexMiceMice, Inbred StrainsT-LymphocytesTransplantation, HomologousTransplantation, IsogeneicConceptsT cellsAllogeneic boneMajor histocompatibility complexHistocompatibility complexAlloreactive T cellsClass II determinantsPurified T cellsSpecific immune responseT cell responsivenessMixed lymphocyte cultureCell surface phenotypeStrains of miceBone marrow cellsState of activationStimulating antigenImmune responseBone donorsAntigen specificityBone marrowLymphocyte culturesSecondary exposurePrimed cellsResponding cellsAntigenBone
1989
Allograft incorporation: A biomechanical evaluation in a rat model
Pelker R, McKay J, Troiano N, Panjabi M, Friedlaender G. Allograft incorporation: A biomechanical evaluation in a rat model. Journal Of Orthopaedic Research® 1989, 7: 585-589. PMID: 2786956, DOI: 10.1002/jor.1100070417.Peer-Reviewed Original ResearchConceptsLewis ratsLevel of freezingImmunologic responseSprague-Dawley rat femursRat modelImmune responseAllogeneic boneFresh allograftsOsteosynthesis siteBiomechanical evaluationBiomechanical testingBiologic responseSubsequent healingAllograftsRat femurRatsIntact boneBoneFemurSignificant levelsResponseTransplantationTransplantGraftWeeks
1984
Transplantation of Osteochondral Allografts
Friedlaender G, Mankin H. Transplantation of Osteochondral Allografts. Annual Review Of Medicine 1984, 35: 311-324. PMID: 6372659, DOI: 10.1146/annurev.me.35.020184.001523.Peer-Reviewed Original ResearchConceptsOsteochondral allograftsMassive osteochondral allograftsExcellent clinical resultsLimb-sparing approachesClinical resultsSkeletal deficitsBone tumorsImmune responseNeoplastic disordersCartilage graftsAllograftsSatisfactory tissueGraftEffective boneTransplantationLesionsTumorsInfectionAntigenBiological significanceStudies on the antigenicity of bone. II. Donor-specific anti-HLA antibodies in human recipients of freeze-dried allografts.
Friedlaender G, Strong D, Sell K. Studies on the antigenicity of bone. II. Donor-specific anti-HLA antibodies in human recipients of freeze-dried allografts. Journal Of Bone And Joint Surgery 1984, 66: 107-12. PMID: 6361041, DOI: 10.2106/00004623-198466010-00014.Peer-Reviewed Original ResearchConceptsDonor-specific anti-HLA antibodiesAnti-HLA antibodiesBone allograftImmune responseFreeze-dried bone allograftFreeze-dried allograftNinth patientAllograft donorsClinical eventsAllograftsPatientsHuman recipientsGraftAdverse effectsRecipientsAntibodiesMonthsBenign processSuch responsesResponseHLADonorsTissue types
1983
Immune responses to osteochondral allografts. Current knowledge and future directions.
Friedlaender G. Immune responses to osteochondral allografts. Current knowledge and future directions. Clinical Orthopaedics And Related Research® 1983, 58-68. PMID: 6339143.Peer-Reviewed Original ResearchConceptsImmune responseReconstructive joint surgeryGraft recipientsAllograft immunogenicityAllograft successHistocompatibility antigensJoint surgeryAnimal modelsBone graftOsteochondral allograftsHuman recipientsBiomechanical factorsAllograftsImmunogenHeterogeneous cell typesPreliminary evidenceImmunogenicityRecipientsCell typesCurrent knowledgeMatter of speculationSkeletal tissuesTissuePotent sourceResponse
1975
A laboratory model for the study of the immunobiology of osteosarcoma
Friedlaender G, Mitchell M. A laboratory model for the study of the immunobiology of osteosarcoma. Cancer 1975, 36: 1631-1639. PMID: 172215, DOI: 10.1002/1097-0142(197511)36:5<1631::aid-cncr2820360516>3.0.co;2-w.Peer-Reviewed Original ResearchConceptsCell-mediated immunityRegression of diseaseWistar-Lewis ratsMoloney sarcomasMoloney sarcoma virusProgressive diseaseClinical courseLung metastasesMicrocytotoxicity assayTreatment protocolImmune responseImmunologic similaritiesHuman osteosarcomaSerum factorsTumor cellsMarrow cavityOsteosarcomaTarget cellsRatsTumorsDiseaseSarcoma virusAnimalsWeeks of inoculationTissue culture