A review of the clinical experience with recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in orthopaedic bone repair and regeneration
DiGiovanni C, Glazebrook M, Snel L, Beasley B, Lynch S, Friedlaender G. A review of the clinical experience with recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in orthopaedic bone repair and regeneration. Current Orthopaedic Practice 2013, 24: 476-481. DOI: 10.1097/bco.0b013e3182a593e6.Peer-Reviewed Original ResearchRecombinant human platelet-derived growth factor-BBVascular endothelial growth factorMechanism of actionClinical experienceMesenchymal stem cellsEnd-stage ankle arthritisRecombinant human PDGFPreclinical safety profileHuman platelet-derived growth factor-BBPlatelet-derived growth factor-BBRotator cuff repairTissue repairEndothelial growth factorGrowth factor-BBDiabetic patientsAnkle arthritisChronic footSafety profilePeriodontal diseasePreclinical dataEfficacy profileClinical studiesClinical investigationCuff repairBone repairThe role of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in orthopaedic bone repair and regeneration.
Friedlaender GE, Lin S, Solchaga LA, Snel LB, Lynch SE. The role of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in orthopaedic bone repair and regeneration. Current Pharmaceutical Design 2013, 19: 3384-90. PMID: 23432673, DOI: 10.2174/1381612811319190005.Peer-Reviewed Original ResearchConceptsRecombinant human platelet-derived growth factor-BBClinical studiesMesenchymal stem cellsRecombinant human PDGFStrong mitogenic factorHuman platelet-derived growth factor-BBPlatelet-derived growth factor-BBPivotal clinical studiesImproved safety profileTissue repairGrowth factor-BBMechanism of actionDiabetic patientsChronic footSafety profileAnkle fusionPeriodontal diseaseChronic infectionClinical developmentSoft tissue repairAlveolar boneBone autograftHuman PDGFMitogenic factorFactor-BB