1999
LONG-TERM FOLLOW-UP OF PATIENTS WITH OSTEOCHONDRAL ALLOGRAFTS A Correlation Between Immunologic Responses and Clinical Outcome
Friedlaender G, Strong D, Tomford W, Mankin H. LONG-TERM FOLLOW-UP OF PATIENTS WITH OSTEOCHONDRAL ALLOGRAFTS A Correlation Between Immunologic Responses and Clinical Outcome. Orthopedic Clinics Of North America 1999, 30: 583-588. PMID: 10471763, DOI: 10.1016/s0030-5898(05)70111-5.Peer-Reviewed Original ResearchConceptsClinical outcomesImmunologic responseHistocompatibility antigensLong-term clinical outcomesLong-term resultsFrozen bone allograftsPresence of sensitizationFrozen osteochondral allograftsImmune responseBone allograftAnimal modelsSatisfactory outcomeOsteochondral allograftsReconstructive alternativeClass IIBiologic successAllograftsOutcomesAntigenResponsePatientsHumansSensitization
1992
Immune responses to osteochondral allografts: nature and significance.
Friedlaender G, Horowitz M. Immune responses to osteochondral allografts: nature and significance. Orthopedics 1992, 15: 1171-5. PMID: 1409127, DOI: 10.3928/0147-7447-19921001-08.Peer-Reviewed Original ResearchConceptsImmune responseOsteochondral allograftsSuppressor/cytotoxic phenotypeBiologic significanceNumerous animal modelsT cell activationCell surface antigensMajor histocompatibility complexClinical resultsCytotoxic phenotypeBone allograftAnimal modelsSurface antigenBone graftAllograftsBiologic outcomesHistocompatibility complexCellular elementsGraftAntigenResponseImmunogenicitySignificance
1984
Effects of chemotherapeutic agents on bone. I. Short-term methotrexate and doxorubicin (adriamycin) treatment in a rat model.
Friedlaender G, Tross R, Doganis A, Kirkwood J, Baron R. Effects of chemotherapeutic agents on bone. I. Short-term methotrexate and doxorubicin (adriamycin) treatment in a rat model. Journal Of Bone And Joint Surgery 1984, 66: 602-7. PMID: 6707039, DOI: 10.2106/00004623-198466040-00016.Peer-Reviewed Original ResearchConceptsChemotherapeutic agentsShort-term methotrexateThickness of osteoidShort-term administrationTrabecular bone volumeNumber of osteoclastsPhysiological bone turnoverWistar-Lewis ratsBone formation rateTotal bone massBone allograft incorporationRate of resorptionChronic treatmentBone turnoverNew bone formationTherapeutic dosesBone massUntreated ratsRat modelBone allograftBone volumeProximal tail vertebraeOsteoblastic activityDoxorubicin treatmentAdverse effectsStudies on the antigenicity of bone. II. Donor-specific anti-HLA antibodies in human recipients of freeze-dried allografts.
Friedlaender G, Strong D, Sell K. Studies on the antigenicity of bone. II. Donor-specific anti-HLA antibodies in human recipients of freeze-dried allografts. Journal Of Bone And Joint Surgery 1984, 66: 107-12. PMID: 6361041, DOI: 10.2106/00004623-198466010-00014.Peer-Reviewed Original ResearchConceptsDonor-specific anti-HLA antibodiesAnti-HLA antibodiesBone allograftImmune responseFreeze-dried bone allograftFreeze-dried allograftNinth patientAllograft donorsClinical eventsAllograftsPatientsHuman recipientsGraftAdverse effectsRecipientsAntibodiesMonthsBenign processSuch responsesResponseHLADonorsTissue types
1983
FROZEN AND FREEZE-DRIED BONE GRAFTS
PELKER R, FRIEDLAENDER G, MARKHAM T. FROZEN AND FREEZE-DRIED BONE GRAFTS. Clinical Orthopaedics And Related Research® 1983, 174: 36-42. PMID: 6339142, DOI: 10.1097/00003086-198304000-00007.Peer-Reviewed Original ResearchBiomechanical Properties of Bone Allografts
Pelker R, Friedlaender G, Markham T. Biomechanical Properties of Bone Allografts. Clinical Orthopaedics And Related Research® 1983, 174: 54-57. PMID: 6339144, DOI: 10.1097/00003086-198304000-00009.Peer-Reviewed Original ResearchConceptsOrthopaedic oncology serviceLow-grade tumorsPresence of recurrenceRelationship of complicationsMassachusetts General HospitalAllograft fractureOncology servicesAllograft implantationFunctional statusSkin sloughGeneral HospitalBone allograftIntramedullary rodFunctional restorationPatientsBenign conditionsResectionBone conditionsCadaveric segmentsComplicationsGraftBiomechanical propertiesTumorsMore yearsInfection
1978
Clinical Evaluation of Freezedried Bone Allografts in Periodontal Osseous Defects‐Part II
Sepe W, Bowers G, Lawrence J, Friedlaender G, Koch R. Clinical Evaluation of Freezedried Bone Allografts in Periodontal Osseous Defects‐Part II. Journal Of Periodontology 1978, 49: 9-14. PMID: 340637, DOI: 10.1902/jop.1978.49.1.9.Peer-Reviewed Original Research
1976
The use of freeze-dried bone in middle-third face advancements
Epker B, Friedlaender G, Wolford L, West R. The use of freeze-dried bone in middle-third face advancements. Oral Surgery Oral Medicine Oral Pathology And Oral Radiology 1976, 42: 278-289. PMID: 787861, DOI: 10.1016/0030-4220(76)90161-4.Peer-Reviewed Original ResearchConceptsFreeze-dried bone allograftPrimary operative procedureFreeze-dried boneMedical Research InstituteNaval Medical Research InstituteSmall sequestrumAdditional surgeryOperative procedureClinical infectionBone allograftPatientsMaxillary areaAutogenous boneGraft materialInfectionTissue banksIntraoral exposureAllograftsBoneGraftMorbiditySequestrumComplicationsSurgeryOsteotomy