Effects of chemotherapeutic agents on bone. I. Short-term methotrexate and doxorubicin (adriamycin) treatment in a rat model.
Friedlaender G, Tross R, Doganis A, Kirkwood J, Baron R. Effects of chemotherapeutic agents on bone. I. Short-term methotrexate and doxorubicin (adriamycin) treatment in a rat model. Journal Of Bone And Joint Surgery 1984, 66: 602-7. PMID: 6707039, DOI: 10.2106/00004623-198466040-00016.Peer-Reviewed Original ResearchConceptsChemotherapeutic agentsShort-term methotrexateThickness of osteoidShort-term administrationTrabecular bone volumeNumber of osteoclastsPhysiological bone turnoverWistar-Lewis ratsBone formation rateTotal bone massBone allograft incorporationRate of resorptionChronic treatmentBone turnoverNew bone formationTherapeutic dosesBone massUntreated ratsRat modelBone allograftBone volumeProximal tail vertebraeOsteoblastic activityDoxorubicin treatmentAdverse effectsStudies on the antigenicity of bone. II. Donor-specific anti-HLA antibodies in human recipients of freeze-dried allografts.
Friedlaender G, Strong D, Sell K. Studies on the antigenicity of bone. II. Donor-specific anti-HLA antibodies in human recipients of freeze-dried allografts. Journal Of Bone And Joint Surgery 1984, 66: 107-12. PMID: 6361041, DOI: 10.2106/00004623-198466010-00014.Peer-Reviewed Original ResearchConceptsDonor-specific anti-HLA antibodiesAnti-HLA antibodiesBone allograftImmune responseFreeze-dried bone allograftFreeze-dried allograftNinth patientAllograft donorsClinical eventsAllograftsPatientsHuman recipientsGraftAdverse effectsRecipientsAntibodiesMonthsBenign processSuch responsesResponseHLADonorsTissue types