Glucocorticoid Receptor (NR3C1) Variants Associate with the Muscle Strength and Size Response to Resistance Training
Ash GI, Kostek MA, Lee H, Angelopoulos TJ, Clarkson PM, Gordon PM, Moyna NM, Visich PS, Zoeller RF, Price TB, Devaney JM, Gordish-Dressman H, Thompson PD, Hoffman EP, Pescatello LS. Glucocorticoid Receptor (NR3C1) Variants Associate with the Muscle Strength and Size Response to Resistance Training. PLOS ONE 2016, 11: e0148112. PMID: 26821164, PMCID: PMC4731199, DOI: 10.1371/journal.pone.0148112.Peer-Reviewed Original ResearchConceptsMaximum voluntary contractionResistance trainingMuscle strengthPost-resistance trainingGlucocorticoid receptor polymorphismsGreater relative sizeCortisol sensitivityReceptor polymorphismsNR3C1 polymorphismsVoluntary contractionAllele carriersCortisol actionMuscle responsesCortisol productionRT programIsometric strengthAA homozygotesG alleleT alleleVariant associatesBiceps sizeEuropean American adultsSex differencesMuscle tissueAssociation