2023
An observational human study investigating the effect of anabolic androgenic steroid use on the transcriptome of skeletal muscle and whole blood using RNA-Seq
Kolliari-Turner A, Lima G, Wang G, Malinsky F, Karanikolou A, Eichhorn G, Tanisawa K, Ospina-Betancurt J, Hamilton B, Kumi P, Shurlock J, Skiadas V, Twycross-Lewis R, Kilduff L, Martin R, Ash G, Potter C, Guppy F, Seto J, Fossati C, Pigozzi F, Borrione P, Pitsiladis Y. An observational human study investigating the effect of anabolic androgenic steroid use on the transcriptome of skeletal muscle and whole blood using RNA-Seq. BMC Medical Genomics 2023, 16: 94. PMID: 37138349, PMCID: PMC10157927, DOI: 10.1186/s12920-023-01512-z.Peer-Reviewed Original ResearchConceptsAnabolic androgenic steroidsWhole bloodWhole blood transcriptional signaturesBlood transcriptional signaturesSkeletal muscleTranscriptional signatureObservational human studiesLong-term cessationAnabolic-androgenic steroid useSteroid useAAS exposureSedentary controlsAndrogen receptorBackgroundThe effectsHuman studiesHypertrophic processAndrogenic steroidsHuman whole bloodAAS usersBloodGroup comparisonsTime pointsTraining regimensMuscleAAS usage
2021
Cross-platform transcriptomic profiling of the response to recombinant human erythropoietin
Wang G, Kitaoka T, Crawford A, Mao Q, Hesketh A, Guppy FM, Ash GI, Liu J, Gerstein MB, Pitsiladis YP. Cross-platform transcriptomic profiling of the response to recombinant human erythropoietin. Scientific Reports 2021, 11: 21705. PMID: 34737331, PMCID: PMC8568984, DOI: 10.1038/s41598-021-00608-9.Peer-Reviewed Original ResearchConceptsRNA-seqDifferential gene expressionPathway enrichment analysisRNA biologyTranscriptomic profilingTarget genesEnrichment analysisGene expressionEPO biologyMicroarray platformGene correlateCross-platform comparisonGenesBiologyImmune regulationHuman erythropoietinTissue protectionProfilingRegulationErythropoietinRecombinant human erythropoietinExpressionImportant toolErythropoiesisOxygen transport