2023
An observational human study investigating the effect of anabolic androgenic steroid use on the transcriptome of skeletal muscle and whole blood using RNA-Seq
Kolliari-Turner A, Lima G, Wang G, Malinsky F, Karanikolou A, Eichhorn G, Tanisawa K, Ospina-Betancurt J, Hamilton B, Kumi P, Shurlock J, Skiadas V, Twycross-Lewis R, Kilduff L, Martin R, Ash G, Potter C, Guppy F, Seto J, Fossati C, Pigozzi F, Borrione P, Pitsiladis Y. An observational human study investigating the effect of anabolic androgenic steroid use on the transcriptome of skeletal muscle and whole blood using RNA-Seq. BMC Medical Genomics 2023, 16: 94. PMID: 37138349, PMCID: PMC10157927, DOI: 10.1186/s12920-023-01512-z.Peer-Reviewed Original ResearchMeSH KeywordsAnabolic AgentsAnabolic Androgenic SteroidsHumansMaleMuscle, SkeletalProteomicsRNA-SeqTestosterone CongenersTranscriptomeConceptsAnabolic androgenic steroidsWhole bloodWhole blood transcriptional signaturesBlood transcriptional signaturesSkeletal muscleTranscriptional signatureObservational human studiesLong-term cessationAnabolic-androgenic steroid useSteroid useAAS exposureSedentary controlsAndrogen receptorBackgroundThe effectsHuman studiesHypertrophic processAndrogenic steroidsHuman whole bloodAAS usersBloodGroup comparisonsTime pointsTraining regimensMuscleAAS usage
2018
A genetic variant in IL‐15Rα correlates with physical activity among European–American adults
Bruneau M, Walsh S, Selinsky E, Ash G, Angelopoulos TJ, Clarkson P, Gordon P, Moyna N, Visich P, Zoeller R, Thompson P, Gordish‐Dressman H, Hoffman E, Devaney J, Pescatello LS. A genetic variant in IL‐15Rα correlates with physical activity among European–American adults. Molecular Genetics & Genomic Medicine 2018, 6: 401-408. PMID: 29624921, PMCID: PMC6014439, DOI: 10.1002/mgg3.368.Peer-Reviewed Original ResearchConceptsPhysical activity phenotypesMuscle strengthPhysical activityPaffenbarger Physical Activity QuestionnaireLight-intensity physical activityHabitual physical activityPhysical Activity QuestionnaireIntensity physical activityActivity phenotypesInterleukin-15Activity QuestionnaireResistance trainingCC genotypeAnalysis of covarianceProtein breakdownEuropean American adultsMenPhenotypeGenotypesMyokinesBMIWomen
2016
Glucocorticoid Receptor (NR3C1) Variants Associate with the Muscle Strength and Size Response to Resistance Training
Ash GI, Kostek MA, Lee H, Angelopoulos TJ, Clarkson PM, Gordon PM, Moyna NM, Visich PS, Zoeller RF, Price TB, Devaney JM, Gordish-Dressman H, Thompson PD, Hoffman EP, Pescatello LS. Glucocorticoid Receptor (NR3C1) Variants Associate with the Muscle Strength and Size Response to Resistance Training. PLOS ONE 2016, 11: e0148112. PMID: 26821164, PMCID: PMC4731199, DOI: 10.1371/journal.pone.0148112.Peer-Reviewed Original ResearchConceptsMaximum voluntary contractionResistance trainingMuscle strengthPost-resistance trainingGlucocorticoid receptor polymorphismsGreater relative sizeCortisol sensitivityReceptor polymorphismsNR3C1 polymorphismsVoluntary contractionAllele carriersCortisol actionMuscle responsesCortisol productionRT programIsometric strengthAA homozygotesG alleleT alleleVariant associatesBiceps sizeEuropean American adultsSex differencesMuscle tissueAssociation