2017
Deep‐targeted sequencing of endothelial nitric oxide synthase gene exons uncovers exercise intensity and ethnicity‐dependent associations with post‐exercise hypotension
Pescatello LS, Schifano ED, Ash GI, Panza GA, Corso LML, Chen M, Deshpande V, Zaleski A, Cilhoroz B, Farinatti P, Taylor BA, O'Neill RJ, Thompson PD. Deep‐targeted sequencing of endothelial nitric oxide synthase gene exons uncovers exercise intensity and ethnicity‐dependent associations with post‐exercise hypotension. Physiological Reports 2017, 5: e13510. PMID: 29180482, PMCID: PMC5704084, DOI: 10.14814/phy2.13510.Peer-Reviewed Original ResearchConceptsPost-exercise hypotensionAmbulatory blood pressure responsesBlood pressure responseAmbulatory BP monitorObese African AmericansModerate-intensity exerciseModerate-intensity cyclingMultiple testing thresholdDiastolic BPAcute exerciseValidation cohortBP measurementsBP monitorIntensity exerciseVigorous intensityVariant genotypesIntensity cyclingMmHgTesting thresholdMinor alleleModerate intensityPressure responseHypotensionHypertensionAfrican Americans
2016
Effects of aerobic exercise intensity on ambulatory blood pressure and vascular responses in resistant hypertension
Santos LP, Moraes RS, Vieira PJ, Ash GI, Waclawovsky G, Pescatello LS, Umpierre D. Effects of aerobic exercise intensity on ambulatory blood pressure and vascular responses in resistant hypertension. Journal Of Hypertension 2016, 34: 1317-1324. PMID: 27137175, DOI: 10.1097/hjh.0000000000000961.Peer-Reviewed Original ResearchConceptsForearm blood flowResistant hypertensionDiastolic pressureAmbulatory BPBlood flowExercise intensityPoor blood pressure controlAmbulatory systolic pressureDevice-based proceduresAcute hemodynamic effectsBlood pressure controlAmbulatory blood pressureVenous occlusion plethysmographyMaximal exercise testingModerate aerobic exerciseModerate intensityAerobic exercise intensityVascular resistanceExercise testingHemodynamic effectsOcclusion plethysmographyBlood pressureResistant patientsSystolic pressureReactive hyperemia
2013
The promises and challenges of the use of genomics in the prescription of exercise for hypertension: the 2013 update.
Ash GI, Eicher JD, Pescatello LS. The promises and challenges of the use of genomics in the prescription of exercise for hypertension: the 2013 update. Current Hypertension Reviews 2013, 9: 130-47. PMID: 23971695, DOI: 10.2174/15734021113099990010.Peer-Reviewed Original ResearchConceptsBP responseCardiovascular disease risk factorsMajor global public health problemGlobal public health problemControl of hypertensionDisease risk factorsEffectiveness of exercisePrescription of exercisePublic health problemExercise prescriptionRisk factorsHypertensionTherapeutic modalitiesAmerican CollegeConsiderable individual variabilityHealth problemsSports medicineAerobic activityModerate intensityNext-generation sequencingAssociation studiesSpecific genetic variantsSignificant proportionMost daysGenetic variants