2019
FURIN variant associations with postexercise hypotension are intensity and race dependent
Cilhoroz BT, Schifano ED, Panza GA, Ash GI, Corso L, Chen M, Deshpande V, Zaleski A, Farinatti P, Santos LP, Taylor BA, O'Neill RJ, Thompson PD, Pescatello LS. FURIN variant associations with postexercise hypotension are intensity and race dependent. Physiological Reports 2019, 7: e13952. PMID: 30706700, PMCID: PMC6356167, DOI: 10.14814/phy2.13952.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBicyclingBlack or African AmericanBlood PressureCase-Control StudiesExerciseFemaleFurinGenetic Association StudiesGenetic Predisposition to DiseaseHumansHypertensionHypotensionMaleMiddle AgedObesityPhenotypePolymorphism, Single NucleotideRisk FactorsTime FactorsWhite PeopleYoung AdultConceptsPostexercise hypotensionSystolic BPDiastolic BPBlood pressure responseAmbulatory BP monitorBlood pressure regulationModerate-intensity cyclingRace-dependent associationsObese blacksAerobic exerciseBP measurementsBP monitorIntensity cyclingAwake hoursMmHgPressure regulationMinor alleleMerit further explorationPressure responseHypotensionHypertensionP-valueReceptor processingMultiple testing
2017
Deep‐targeted sequencing of endothelial nitric oxide synthase gene exons uncovers exercise intensity and ethnicity‐dependent associations with post‐exercise hypotension
Pescatello LS, Schifano ED, Ash GI, Panza GA, Corso LML, Chen M, Deshpande V, Zaleski A, Cilhoroz B, Farinatti P, Taylor BA, O'Neill RJ, Thompson PD. Deep‐targeted sequencing of endothelial nitric oxide synthase gene exons uncovers exercise intensity and ethnicity‐dependent associations with post‐exercise hypotension. Physiological Reports 2017, 5: e13510. PMID: 29180482, PMCID: PMC5704084, DOI: 10.14814/phy2.13510.Peer-Reviewed Original ResearchConceptsPost-exercise hypotensionAmbulatory blood pressure responsesBlood pressure responseAmbulatory BP monitorObese African AmericansModerate-intensity exerciseModerate-intensity cyclingMultiple testing thresholdDiastolic BPAcute exerciseValidation cohortBP measurementsBP monitorIntensity exerciseVigorous intensityVariant genotypesIntensity cyclingMmHgTesting thresholdMinor alleleModerate intensityPressure responseHypotensionHypertensionAfrican Americans