2020
Identification of a 22 bp DNA cis Element that Plays a Critical Role in Colony Stimulating Factor 1-Dependent Transcriptional Activation of the SPHK1 Gene
Yao GQ, Zhu M, Walker J, Insogna K. Identification of a 22 bp DNA cis Element that Plays a Critical Role in Colony Stimulating Factor 1-Dependent Transcriptional Activation of the SPHK1 Gene. Calcified Tissue International 2020, 107: 52-59. PMID: 32246175, PMCID: PMC7274855, DOI: 10.1007/s00223-020-00685-4.Peer-Reviewed Original ResearchConceptsColony stimulating factor 1Sphingosine kinase 1Bp fragmentSPHK1 promoterBp sequenceSphK1 geneDNA cis elementsProtein binding regionsSPHK1 gene expressionBp DNA fragmentStimulating factor 1Dual-luciferase reporterPutative DNATranscriptional activationTranscription factorsNuclear proteinsDNA sequencesCis elementsDNA bindingGene expressionPromoter activityDNA fragmentsKinase 1EMSAsProtein binding
1996
Inhibition of Epstein-Barr virus replication by a novel l-nucleoside, 2′-fluoro-5-methyl-β-l-arabinofuranosyluracil
Yao G, Liu S, Chou E, Kukhanova M, Chu C, Cheng Y. Inhibition of Epstein-Barr virus replication by a novel l-nucleoside, 2′-fluoro-5-methyl-β-l-arabinofuranosyluracil. Biochemical Pharmacology 1996, 51: 941-947. PMID: 8651944, DOI: 10.1016/0006-2952(96)00049-4.Peer-Reviewed Original ResearchConceptsEpstein-Barr virus replicationL-FMAUNovel L-nucleoside analogVirus replicationEBV DNA polymeraseMechanism of actionL-nucleoside analoguesEBV agentsPotent inhibitory activityAntiviral activityEBVVirus productionInhibitory concentrationViral productionHuman DNA polymerase alphaSelective inhibitorViral DNAInhibitory activityMetabolism studiesCell growthCellsInhibitionDNA polymerase alphaCellular DNANon-producing cells