2024
Book-Sharing for Toddlers with Clefts (BOOST): Protocol for a randomized controlled trial of a remote intervention to promote language development in children with cleft palate
Collett B, Gallagher E, Johns A, Trevino C, Leroux B, Shic F, Crerand C, Baylis A, Cummings C, Santillan L. Book-Sharing for Toddlers with Clefts (BOOST): Protocol for a randomized controlled trial of a remote intervention to promote language development in children with cleft palate. PLOS ONE 2024, 19: e0304630. PMID: 38870107, PMCID: PMC11175488, DOI: 10.1371/journal.pone.0304630.Peer-Reviewed Original ResearchConceptsPromote language developmentLanguage outcomesLanguage developmentParent–child reading interactionsSpanish-speaking childrenChild language outcomesChildren's expressive languageChildren’s booksStandard-of-careReading interactionsBook sharingLanguage delayBook-sharingExpressive languageImprove languageLanguageUpload videosBookCleft palateBoost groupParent-focused interventionsRandomized controlled trialsSkill usageRandomized-controlled trialsToddlers
2023
The Selective Social Attention task in children with autism spectrum disorder: Results from the Autism Biomarkers Consortium for Clinical Trials (ABC‐CT) feasibility study
Shic F, Barney E, Naples A, Dommer K, Chang S, Li B, McAllister T, Atyabi A, Wang Q, Bernier R, Dawson G, Dziura J, Faja S, Jeste S, Murias M, Johnson S, Sabatos‐DeVito M, Helleman G, Senturk D, Sugar C, Webb S, McPartland J, Chawarska K, Trials T. The Selective Social Attention task in children with autism spectrum disorder: Results from the Autism Biomarkers Consortium for Clinical Trials (ABC‐CT) feasibility study. Autism Research 2023, 16: 2150-2159. PMID: 37749934, PMCID: PMC11003770, DOI: 10.1002/aur.3026.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSocial attention taskSchool-aged childrenAttention taskASD groupSpectrum disorderEye-tracking taskTotal T-scoreAttentional patternsAutism spectrumTD groupPresentation timeTrial feasibility studyGroup differencesPercent of timeOlder childrenTaskComparison groupToddlersT-scoreChildrenChildren 4Outcome variablesFaceCondition effectsDevelopment of webcam‐collected and artificial‐intelligence‐derived social and cognitive performance measures for neurodevelopmental genetic syndromes
Frazier T, Busch R, Klaas P, Lachlan K, Jeste S, Kolevzon A, Loth E, Harris J, Speer L, Pepper T, Anthony K, Graglia J, Delagrammatikas C, Bedrosian‐Sermone S, Smith‐Hicks C, Huba K, Longyear R, Green‐Snyder L, Shic F, Sahin M, Eng C, Hardan A, Uljarević M. Development of webcam‐collected and artificial‐intelligence‐derived social and cognitive performance measures for neurodevelopmental genetic syndromes. American Journal Of Medical Genetics Part C Seminars In Medical Genetics 2023, 193: e32058. PMID: 37534867, PMCID: PMC10543620, DOI: 10.1002/ajmg.c.32058.Peer-Reviewed Original ResearchConceptsCognitive processesSingle word readingCognitive performance measuresStimulus paradigmParent-report measuresGaze-based measuresEvidence of convergentNeurodevelopmental disabilitiesInitial psychometric evaluationDiscriminant validity analysesReceptive vocabularyCognitive functioningSocial attentionNeurotypical controlsProcessing difficultiesExamination of sensitivityInternal consistency reliabilityBehavioral constructsDiscriminant validityPerformance measuresValidity analysisPsychometric evaluationIntellectual disabilityAdditional validation workConsistency reliabilityEvaluation of clinical assessments of social abilities for use in autism clinical trials by the autism biomarkers consortium for clinical trials
Faja S, Sabatos‐DeVito M, Sridhar A, Kuhn J, Nikolaeva J, Sugar C, Webb S, Bernier R, Sikich L, Hellemann G, Senturk D, Naples A, Shic F, Levin A, Seow H, Dziura J, Jeste S, Chawarska K, Nelson C, Dawson G, McPartland J, Trials A. Evaluation of clinical assessments of social abilities for use in autism clinical trials by the autism biomarkers consortium for clinical trials. Autism Research 2023, 16: 981-996. PMID: 36929131, PMCID: PMC10192100, DOI: 10.1002/aur.2905.Peer-Reviewed Original Research
2022
Distinct social attention profiles in preschoolers with autism contrasted to fragile X syndrome
Wall C, Shic F, Varanasi S, Roberts J. Distinct social attention profiles in preschoolers with autism contrasted to fragile X syndrome. Autism Research 2022, 16: 340-354. PMID: 36408848, PMCID: PMC9957831, DOI: 10.1002/aur.2857.Peer-Reviewed Original ResearchConceptsNon-syndromic autism spectrum disorderAttention profilesSocial attentionSocial anxietyEye contactFacial attentionASD severityFragile X syndromeSocial attention deficitsReduced eye contactCross-syndrome approachAutism spectrum disorderCo-occurring diagnosesAttention difficultiesNT childrenAttention deficitsSocial avoidanceSpectrum disorderX syndromePreschool childrenCritical skillsAnxietyIntellectual disabilityIntellectual impairmentChildren
2021
Preference for biological motion is reduced in ASD: implications for clinical trials and the search for biomarkers
Mason L, Shic F, Falck-Ytter T, Chakrabarti B, Charman T, Loth E, Tillmann J, Banaschewski T, Baron-Cohen S, Bölte S, Buitelaar J, Durston S, Oranje B, Persico A, Beckmann C, Bougeron T, Dell’Acqua F, Ecker C, Moessnang C, Murphy D, Johnson M, Jones E. Preference for biological motion is reduced in ASD: implications for clinical trials and the search for biomarkers. Molecular Autism 2021, 12: 74. PMID: 34911565, PMCID: PMC8672507, DOI: 10.1186/s13229-021-00476-0.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderBiological motion preferenceBiological motionASD groupNeurotypical participantsMotion preferencesSocial-communicative symptomsSocial-communicative skillsBiological motion stimuliSocial brain functionSocial brain regionsLow-IQ individualsLow average IQNeurocognitive mechanismsAutistic differencesIndividual differencesMotion stimuliControl stimuliLater symptomatologySpectrum disorderAverage IQCommunicative skillsVisual preferenceSocial autismControl participants
2015
Brief Report: A Mobile Application to Treat Prosodic Deficits in Autism Spectrum Disorder and Other Communication Impairments: A Pilot Study
Simmons ES, Paul R, Shic F. Brief Report: A Mobile Application to Treat Prosodic Deficits in Autism Spectrum Disorder and Other Communication Impairments: A Pilot Study. Journal Of Autism And Developmental Disorders 2015, 46: 320-327. PMID: 26329637, DOI: 10.1007/s10803-015-2573-8.Peer-Reviewed Original ResearchConceptsSpeech-language pathologistsStudent engagement dataPost-treatment speech samplesEducation settingsPublic schoolsProsodic disordersEngagement dataStudentsEngagement ratingsMobile applicationsAutism spectrum disorderCommunication impairmentsProsody deficitsSpectrum disorderSchoolsPilot studyFeedbackRatingsProsodic deficitsChildrenASDComputer-Assisted Face Processing Instruction Improves Emotion Recognition, Mentalizing, and Social Skills in Students with ASD
Rice LM, Wall CA, Fogel A, Shic F. Computer-Assisted Face Processing Instruction Improves Emotion Recognition, Mentalizing, and Social Skills in Students with ASD. Journal Of Autism And Developmental Disorders 2015, 45: 2176-2186. PMID: 25694364, DOI: 10.1007/s10803-015-2380-2.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSocial skillsSchool-aged childrenAffect recognitionFace processing skillsFacial recognition skillsSocial skills interventionsSocial skills domainComputer-based interventionsJoint attentionRecognition skillsEmotion recognitionSkills interventionEye gazeSpectrum disorderProcessing instructionMentalizingSkillsEducational criteriaRandomized control trialInterventionChildrenRecognitionControl trialStudents
2013
Speech Disturbs Face Scanning in 6-Month-Old Infants Who Develop Autism Spectrum Disorder
Shic F, Macari S, Chawarska K. Speech Disturbs Face Scanning in 6-Month-Old Infants Who Develop Autism Spectrum Disorder. Biological Psychiatry 2013, 75: 231-237. PMID: 23954107, PMCID: PMC3864607, DOI: 10.1016/j.biopsych.2013.07.009.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSpectrum disorderComplex social scenesAttention of infantsCritical developmental pointPresence of speechPositive affectASD outcomeGaze patternsSocial scenesSocial targetsDevelopmental pointInner featuresSocial worldOlder infantsAtypical behaviorScanning patternsSpontaneous deploymentsFaceMonths of ageAttentionDisordersAffectClinical outcomesComprehensive assessmentDecreased Spontaneous Attention to Social Scenes in 6-Month-Old Infants Later Diagnosed with Autism Spectrum Disorders
Chawarska K, Macari S, Shic F. Decreased Spontaneous Attention to Social Scenes in 6-Month-Old Infants Later Diagnosed with Autism Spectrum Disorders. Biological Psychiatry 2013, 74: 195-203. PMID: 23313640, PMCID: PMC3646074, DOI: 10.1016/j.biopsych.2012.11.022.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderSocial scenesSpectrum disorderSocial brain networkEye-tracking taskAttentional biasSocial cognitionSocial overturesSpontaneous attentionAtypical developmentEnhanced attentionBrain networksSocial interaction patternsMonitoring skillsOlder infantsVisual responsesProdromal symptomsDiminished abilityInteraction patternsLimited attentionDisordersFirst yearAttentionSceneCognition
2012
Social Robots as Embedded Reinforcers of Social Behavior in Children with Autism
Kim ES, Berkovits LD, Bernier EP, Leyzberg D, Shic F, Paul R, Scassellati B. Social Robots as Embedded Reinforcers of Social Behavior in Children with Autism. Journal Of Autism And Developmental Disorders 2012, 43: 1038-1049. PMID: 23111617, DOI: 10.1007/s10803-012-1645-2.Peer-Reviewed Original ResearchConceptsSocial robotsAdult confederateSocial human-robot interactionSocial behaviorInteraction partnersAutism spectrum disorderHuman-robot interactionSocial skillsSpectrum disorderMore speechCommunication therapySocial interactionComputer gamesRobotAutismConfederateReinforcersChildrenIntrinsic reinforcersAdult humansPartnersSpeechSkillsLarge demonstrationsMotivators
2010
Limited activity monitoring in toddlers with autism spectrum disorder
Shic F, Bradshaw J, Klin A, Scassellati B, Chawarska K. Limited activity monitoring in toddlers with autism spectrum disorder. Brain Research 2010, 1380: 246-254. PMID: 21129365, PMCID: PMC3050079, DOI: 10.1016/j.brainres.2010.11.074.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderTypical developmentSpectrum disorderAdult–child play interactionsGreater autism severityAutism severityObservational learningDevelopmental delayPlay interactionsCognitive deficitsDevelopmental progressionPeople's headsToddlersSocial activitiesFuture avenuesLess attentionBackground objectsAutismDisordersDeficitsLearningAttentionPeopleObjectsContext
2009
Looking But Not Seeing: Atypical Visual Scanning and Recognition of Faces in 2 and 4-Year-Old Children with Autism Spectrum Disorder
Chawarska K, Shic F. Looking But Not Seeing: Atypical Visual Scanning and Recognition of Faces in 2 and 4-Year-Old Children with Autism Spectrum Disorder. Journal Of Autism And Developmental Disorders 2009, 39: 1663. PMID: 19590943, PMCID: PMC4878114, DOI: 10.1007/s10803-009-0803-7.Peer-Reviewed Original Research
2003
Automated data processing of {1H-decoupled} 13C MR spectra acquired from human brain in vivo
Shic F, Ross B. Automated data processing of {1H-decoupled} 13C MR spectra acquired from human brain in vivo. Journal Of Magnetic Resonance 2003, 162: 259-268. PMID: 12810010, DOI: 10.1016/s1090-7807(03)00117-4.Peer-Reviewed Original ResearchReduced glutamate neurotransmission in patients with Alzheimer's disease–an in vivo 13C magnetic resonance spectroscopy study
Lin AP, Shic F, Enriquez C, Ross BD. Reduced glutamate neurotransmission in patients with Alzheimer's disease–an in vivo 13C magnetic resonance spectroscopy study. Magnetic Resonance Materials In Physics, Biology And Medicine 2003, 16: 29-42. PMID: 12695884, DOI: 10.1007/s10334-003-0004-x.Peer-Reviewed Original ResearchConceptsN-acetyl aspartateGlutamate neurotransmissionAlzheimer's diseaseCognitive impairmentAD patientsMagnetic resonance spectroscopy measuresPosterior parietal white matterNeuronal tricarboxylic acid cycleCerebral metabolic rateMagnetic resonance spectroscopy studyAge-matched controlsNAA/CrMyo-inositol ratioCognitive impairment characteristicGlucose oxidationMRS measuresNeuronal integrityNeuronal TCA cycleWhite matterGray matterImpairment characteristicPatientsEnrichment of glutamateGlucose ivPilot study
2002
Tricarboxylic acid cycle of glia in the in vivo human brain
Blüml S, Moreno‐Torres A, Shic F, Nguy C, Ross B. Tricarboxylic acid cycle of glia in the in vivo human brain. NMR In Biomedicine 2002, 15: 1-5. PMID: 11840547, DOI: 10.1002/nbm.725.Peer-Reviewed Original Research
2001
Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy
Lin A, Nguy C, Shic F, Ross B. Accumulation of methylsulfonylmethane in the human brain: identification by multinuclear magnetic resonance spectroscopy. Toxicology Letters 2001, 123: 169-177. PMID: 11641045, DOI: 10.1016/s0378-4274(01)00396-4.Peer-Reviewed Original ResearchConceptsIntact blood-brain barrierBlood-brain barrierProbable Alzheimer's diseaseMagnetic resonance spectroscopyHuman brainVivo magnetic resonance spectroscopyNeurochemical effectsNormal subjectsNormal volunteersWhite matterAlzheimer's diseaseMethylsulfonylmethaneMemory lossPatientsToxic exposureBrainMedical benefitsResonance spectroscopySubjectsDiseaseDiagnosisDosesDailyVolunteers