Reduced glutamate neurotransmission in patients with Alzheimer's disease–an in vivo 13C magnetic resonance spectroscopy study
Lin AP, Shic F, Enriquez C, Ross BD. Reduced glutamate neurotransmission in patients with Alzheimer's disease–an in vivo 13C magnetic resonance spectroscopy study. Magnetic Resonance Materials In Physics, Biology And Medicine 2003, 16: 29-42. PMID: 12695884, DOI: 10.1007/s10334-003-0004-x.Peer-Reviewed Original ResearchConceptsN-acetyl aspartateGlutamate neurotransmissionAlzheimer's diseaseCognitive impairmentAD patientsMagnetic resonance spectroscopy measuresPosterior parietal white matterNeuronal tricarboxylic acid cycleCerebral metabolic rateMagnetic resonance spectroscopy studyAge-matched controlsNAA/CrMyo-inositol ratioCognitive impairment characteristicGlucose oxidationMRS measuresNeuronal integrityNeuronal TCA cycleWhite matterGray matterImpairment characteristicPatientsEnrichment of glutamateGlucose ivPilot study