2022
Viral Suppression Levels in Men Who Have Sex With Men and Transgender Women With Newly Diagnosed HIV and Alcohol Use Disorder in Peru: Results From a Randomized, Double-Blind, Placebo-Controlled Trial Using Oral Naltrexone
Gonzales P, Bachireddy C, Grieco A, Ding R, de Leon S, Ulrich A, Lama J, Duerr AC, Altice FL. Viral Suppression Levels in Men Who Have Sex With Men and Transgender Women With Newly Diagnosed HIV and Alcohol Use Disorder in Peru: Results From a Randomized, Double-Blind, Placebo-Controlled Trial Using Oral Naltrexone. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2022, 89: 462-471. PMID: 34897226, PMCID: PMC8881312, DOI: 10.1097/qai.0000000000002889.Peer-Reviewed Original ResearchConceptsMSM/transgender womenAlcohol use disorderOral naltrexoneTransgender womenViral suppressionUse disordersEFV/TDF/FTCTreatment of AUDMaximal viral suppressionSingle treatment regimenPlacebo-controlled trialTDF/FTCAntiretroviral therapy adherenceUse of naltrexoneEvidence-based treatmentsViral suppression levelsMVs levelsSecondary outcomesTherapy adherenceLow adherenceAdherence levelsNaltrexoneAUD treatmentHIVPlacebo
2020
Safety of oral naltrexone in HIV-positive men who have sex with men and transgender women with alcohol use disorder and initiating antiretroviral therapy
Gonzales P, Grieco A, White E, Ding R, Ignacio RB, Pinto-Santini D, Lama JR, Altice FL, Duerr A. Safety of oral naltrexone in HIV-positive men who have sex with men and transgender women with alcohol use disorder and initiating antiretroviral therapy. PLOS ONE 2020, 15: e0228433. PMID: 32134956, PMCID: PMC7058313, DOI: 10.1371/journal.pone.0228433.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAntiretroviral therapyClinical adverse eventsAdverse eventsTransgender womenUse disordersDouble-blind randomized placebo-controlled trialMSM/transgender womenRandomized placebo-controlled trialART-naïve participantsPossibility of hepatotoxicityPlacebo-controlled trialSerious adverse eventsHIV-positive menMedication-assisted therapyProportion of subjectsAdverse event dataMultiple new medicationsOral naltrexoneStudy medicationTransaminase elevationPlacebo armNTX treatmentTreatment armsNew medications
2018
Extended-release Naltrexone Improves Viral Suppression Among Incarcerated Persons Living with HIV and Alcohol use Disorders Transitioning to the Community
Springer SA, Di Paola A, Barbour R, Azar MM, Altice FL. Extended-release Naltrexone Improves Viral Suppression Among Incarcerated Persons Living with HIV and Alcohol use Disorders Transitioning to the Community. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2018, 79: 92-100. PMID: 29781884, PMCID: PMC6092223, DOI: 10.1097/qai.0000000000001759.Peer-Reviewed Original ResearchConceptsAlcohol use disorderViral suppressionExtended-release naltrexoneXR-NTXPlacebo groupPlacebo-controlled trialMonthly injectionsSecondary outcomesTreat analysisIncarcerated individualsEligible participantsWhite raceUse disordersAlcohol consumptionHIVMonthsNaltrexoneBaselineDisordersInjectionIncarcerated peopleParticipantsPlaceboGroupSuppression
2017
Active syphilis and its association with HIV and sexual risk behaviours in a multicity sample of men who have sex with men and transgender women in Peru
Pizzicato LN, Vagenas P, Gonzales P, Lama JR, Pun M, Sanchez J, Altice FL. Active syphilis and its association with HIV and sexual risk behaviours in a multicity sample of men who have sex with men and transgender women in Peru. Sexual Health 2017, 14: 304-312. PMID: 28514994, DOI: 10.1071/sh16149.Peer-Reviewed Original ResearchConceptsActive syphilis infectionActive syphilisIndependent correlatesSyphilis infectionTransgender womenRisk factorsRecent sexRecent sex workSignificant independent correlatesReceptive anal intercourseFemale partnersRecent drug useSexual risk behaviorsTreatment of syphilisBackground SyphilisTGW populationPresent studySyphilis testingSyphilis screeningTransmissible infectionsSyphilis diagnosisHigh prevalenceStratified analysisSyphilis epidemicAge 35
2015
The Impact of Alcohol Use and Related Disorders on the HIV Continuum of Care: a Systematic Review
Vagenas P, Azar MM, Copenhaver MM, Springer SA, Molina PE, Altice FL. The Impact of Alcohol Use and Related Disorders on the HIV Continuum of Care: a Systematic Review. Current HIV/AIDS Reports 2015, 12: 421-436. PMID: 26412084, PMCID: PMC4643391, DOI: 10.1007/s11904-015-0285-5.BooksMeSH KeywordsAlcohol DrinkingAlcoholismAnti-HIV AgentsDrug Administration ScheduleHIV InfectionsHumansConceptsViral suppressionTreatment cascadeAntiretroviral therapyHIV continuumAlcohol useAlcohol consumptionSystematic reviewHIV treatment cascadeEvidence-based behavioralCohort studyHIV progressionHIV transmissionHIV treatmentPharmacological interventionsProblematic alcohol consumptionIncome settingsRelated disordersClinical research papersPrevention mandateCareNegative associationNumerous negative consequencesInterventionPLHTreatmentMen Who Have Sex With Men in Peru: Acceptability of Medication-Assisted Therapy for Treating Alcohol Use Disorders
Brown SE, Vagenas P, Konda KA, Clark JL, Lama JR, Gonzales P, Sanchez J, Duerr AC, Altice FL. Men Who Have Sex With Men in Peru: Acceptability of Medication-Assisted Therapy for Treating Alcohol Use Disorders. American Journal Of Men's Health 2015, 11: 1269-1278. PMID: 25787988, PMCID: PMC4573823, DOI: 10.1177/1557988315576775.Peer-Reviewed Original ResearchConceptsMSM/transgender womenAlcohol use disorderMedication-assisted therapyTransgender womenUse disordersManagement of AUDAntiretroviral therapy adherenceAlcohol problemsRisky sexual behaviorPeruvian MSMTherapy adherenceClinical trialsHIV epidemicTreatment programTotal abstinenceLess alcoholTherapyThematic content analysisMultiple studiesMedicationsSexual behaviorHIVDrinking behaviorMenFamily support
2014
Alcohol use disorders negatively influence antiretroviral medication adherence among men who have sex with men in Peru
Ferro EG, Weikum D, Vagenas P, Copenhaver MM, Gonzales P, Peinado J, Cabello R, Lama JR, Sanchez J, Altice FL. Alcohol use disorders negatively influence antiretroviral medication adherence among men who have sex with men in Peru. AIDS Care 2014, 27: 93-104. PMID: 25277252, PMCID: PMC4221495, DOI: 10.1080/09540121.2014.963013.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcoholismAnti-HIV AgentsHIV InfectionsHomosexuality, MaleHumansMalePatient ComplianceConceptsAntiretroviral therapyART adherenceAlcohol use disorderART nonadherenceIndependent correlatesUse disordersHIV treatment engagementOnly independent correlateClinical care sitesConcentrated HIV epidemicAntiretroviral medication adherenceRecent drug useEvidence-based strategiesStandardized screening measuresAdherence surveyMedication adherenceHIV treatmentHIV epidemicCare sitesClinical careNeurocognitive impairmentMeeting criteriaSectional surveyTreatment engagementDrug useAn evaluation of hepatic enzyme elevations among HIV-infected released prisoners enrolled in two randomized placebo-controlled trials of extended release naltrexone
Vagenas P, Di Paola A, Herme M, Lincoln T, Skiest DJ, Altice FL, Springer SA. An evaluation of hepatic enzyme elevations among HIV-infected released prisoners enrolled in two randomized placebo-controlled trials of extended release naltrexone. Journal Of Substance Use And Addiction Treatment 2014, 47: 35-40. PMID: 24674234, PMCID: PMC4042403, DOI: 10.1016/j.jsat.2014.02.008.Peer-Reviewed Original ResearchConceptsPlacebo-controlled trialXR-NTXGamma-glutamyl transferaseAlanine aminotransferaseMental illnessAspartate aminotransferaseRandomized placebo-controlled trialMonthly injectable formulationXR-NTX armExtended-release naltrexoneHepatic enzyme elevationHepatic enzyme levelsRelease naltrexoneAntiretroviral therapyHCV infectionBaseline characteristicsHepatic transaminasesEnzyme elevationPsychiatric medicationsHepatotoxicity concernsGlutamyl transferaseAlcohol dependenceOpioidsHIVNaltrexone
2013
Design and methods of a double blind randomized placebo-controlled trial of extended-release naltrexone for alcohol dependent and hazardous drinking prisoners with HIV who are transitioning to the community
Springer SA, Altice FL, Herme M, Di Paola A. Design and methods of a double blind randomized placebo-controlled trial of extended-release naltrexone for alcohol dependent and hazardous drinking prisoners with HIV who are transitioning to the community. Contemporary Clinical Trials 2013, 37: 209-218. PMID: 24384538, PMCID: PMC3992862, DOI: 10.1016/j.cct.2013.12.006.Peer-Reviewed Original ResearchConceptsPlacebo-controlled trialHIV treatment outcomesTreatment outcomesCriminal justice system (CJS) populationsPoor antiretroviral therapy (ART) adherenceAlcohol useExtended-release naltrexoneAntiretroviral therapy adherenceMedication-assisted therapyPrevention of relapseAlcohol use disorderSexual risk-taking behaviorsAlcohol-dependent personsXR-NTXHigh morbidityTherapy adherenceAlcohol relapseHigh prevalenceStudy participationEligibility criteriaUse disordersHIVRelapseHazardous drinkingNaltrexonePartner violence and health among HIV-infected jail detainees
Meyer JP, Wickersham JA, Fu JJ, Brown SE, Sullivan TP, Springer SA, Altice FL. Partner violence and health among HIV-infected jail detainees. International Journal Of Prisoner Health 2013, 9: 124-141. PMID: 24376468, PMCID: PMC3873166, DOI: 10.1108/ijph-03-2013-0011.Peer-Reviewed Original ResearchConceptsIntimate partner violenceSubstance use disordersHIV treatment outcomesHealthcare utilizationPartner violenceTreatment outcomesJail detaineesIPV exposureEffects of IPVHIV secondary preventionPost-release interventionsUntreated mental disordersDepth qualitative interviewsLifetime IPV exposureForms of childhoodHigher alcohol use severityCriminal justice populationsAlcohol use severityViolence reductionCJ populationsTime of incarcerationHIV diagnosisSecondary preventionAdulthood abuseQualitative interviewsScreening for Drug and Alcohol Use Disorders and Their Association with HIV-Related Sexual Risk Behaviors among Men Who Have Sex with Men in Peru
Ludford KT, Vagenas P, Lama JR, Peinado J, Gonzales P, Leiva R, Pun M, Sanchez J, Altice FL, . Screening for Drug and Alcohol Use Disorders and Their Association with HIV-Related Sexual Risk Behaviors among Men Who Have Sex with Men in Peru. PLOS ONE 2013, 8: e69966. PMID: 23936364, PMCID: PMC3735581, DOI: 10.1371/journal.pone.0069966.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAdjusted odds ratioAlcohol Use Disorders Identification TestHIV transmissionSexual risk behaviorsHIV epidemicUse disordersCross-sectional bio-behavioural surveyUnprotected sexSexual partnersRisk behaviorsHIV risk-taking behaviorsIncident HIV infectionBio-behavioural surveyMedication-assisted therapyRecent drug useDisorders Identification TestHigh-risk behaviorsLast encounterDependent outcomesHIV infectionMajority of participantsActive MSMIndependent correlatesOdds ratioBeing Unaware of Being HIV-Infected is Associated with Alcohol Use Disorders and High-Risk Sexual Behaviors Among Men Who have Sex with Men in Peru
Vagenas P, Ludford KT, Gonzales P, Peinado J, Cabezas C, Gonzales F, Lama JR, Sanchez J, Altice FL, for the Peruvian HIV Sentinel Surveillance Working Group. Being Unaware of Being HIV-Infected is Associated with Alcohol Use Disorders and High-Risk Sexual Behaviors Among Men Who have Sex with Men in Peru. AIDS And Behavior 2013, 18: 120-127. PMID: 23670711, PMCID: PMC3796203, DOI: 10.1007/s10461-013-0504-2.Peer-Reviewed Original ResearchConceptsAlcohol use disorderHigh-risk sexual behaviorHIV infectionUse disordersMultivariate logistic regressionUnprotected anal intercourseSexual behaviorHIV-InfectedHIV statusSyphilis testingHIV riskAnal intercourseTherapy interventionHIVLogistic regressionMenLast encounterSexInfectionDisordersParticipantsRisk assessmentMSMPeruvian citiesMonthsAlcohol use disorders and antiretroviral therapy among prisoners in Argentina
Alpert M, Wickersham JA, Vázquez M, Altice FL. Alcohol use disorders and antiretroviral therapy among prisoners in Argentina. International Journal Of Prisoner Health 2013, 9: 40-50. PMID: 24772187, PMCID: PMC3999974, DOI: 10.1108/17449201311310797.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAntiretroviral therapyUse disordersSecondary HIV preventionCent of subjectsCross-sectional surveyHIV careSubstance abuse patternsMajority of participantsIndependent correlatesHIV preventionTreatment outcomesGeneral populationHIVHealth care reformAbuse patternsAUDIT scaleCurrent incarcerationDisordersTherapyOne-thirdCare reformOne-quarterParticipantsFuture efforts
2011
HIV Treatment Outcomes Among HIV-Infected, Opioid-Dependent Patients Receiving Buprenorphine/Naloxone Treatment within HIV Clinical Care Settings: Results From a Multisite Study
Altice FL, Bruce RD, Lucas GM, Lum PJ, Korthuis PT, Flanigan TP, Cunningham CO, Sullivan LE, Vergara-Rodriguez P, Fiellin DA, Cajina A, Botsko M, Nandi V, Gourevitch MN, Finkelstein R. HIV Treatment Outcomes Among HIV-Infected, Opioid-Dependent Patients Receiving Buprenorphine/Naloxone Treatment within HIV Clinical Care Settings: Results From a Multisite Study. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2011, 56: s22-s32. PMID: 21317590, PMCID: PMC3263431, DOI: 10.1097/qai.0b013e318209751e.Peer-Reviewed Original ResearchConceptsBUP/NXHIV treatment outcomesCD4 lymphocyte countHIV clinical care settingsAntiretroviral therapyViral suppressionLymphocyte countTreatment outcomesClinical care settingsOpioid dependenceCare settingsLower HIV-1 RNA levelsBuprenorphine/naloxone treatmentHIV-1 RNA levelsInitiation of ARTHIV-1 RNA suppressionComorbid substance use disorderHealth qualityBuprenorphine/naloxoneMultidisciplinary treatment strategyOpioid-dependent patientsGeneral health qualityMental health qualityOpioid-dependent subjectsSubstance use disorders
2010
HIV, alcohol dependence, and the criminal justice system: a review and call for evidence-based treatment for released prisoners
Springer SA, Azar MM, Altice FL. HIV, alcohol dependence, and the criminal justice system: a review and call for evidence-based treatment for released prisoners. The American Journal Of Drug And Alcohol Abuse 2010, 37: 12-21. PMID: 21171933, PMCID: PMC3070290, DOI: 10.3109/00952990.2010.540280.BooksMeSH KeywordsAlcoholismCriminal LawEvidence-Based MedicineHIV InfectionsHumansPrisonersUnited StatesConceptsAlcohol use disorderHIV treatment outcomesTreatment outcomesAlcohol dependencePoor HIV treatment outcomesRole of pharmacotherapyRelationship of HIVHIV risk behaviorsBetter treatment outcomesEvidence-based treatmentsAntiretroviral therapySignificant morbidityTherapeutic optionsPoor adherenceAlcohol abuseHIVUse disordersHIV cycleCommunity settingsRisk behaviorsAlcohol usePrimary articlesImproved treatmentVulnerable populationsNaltrexone
2007
Clinical Care of the HIV-Infected Drug User
Bruce RD, Altice FL. Clinical Care of the HIV-Infected Drug User. Infectious Disease Clinics Of North America 2007, 21: 149-179. PMID: 17502234, PMCID: PMC2128697, DOI: 10.1016/j.idc.2007.03.009.Peer-Reviewed Original Research