1993
Renal mechanism of trimethoprim-induced hyperkalemia.
Velázquez H, Perazella MA, Wright FS, Ellison DH. Renal mechanism of trimethoprim-induced hyperkalemia. Annals Of Internal Medicine 1993, 119: 296-301. PMID: 8328738, DOI: 10.7326/0003-4819-119-4-199308150-00008.Peer-Reviewed Original ResearchConceptsRenal potassium excretionPotassium excretionMammalian distal nephronDistal tubulesTrimethoprim therapyPotassium secretionDistal nephronMale Sprague-Dawley ratsLumen-negative transepithelial voltageTransepithelial voltageNormal adrenocortical functionSeverity of hyperkalemiaTranstubular potassium gradientUrine electrolyte levelsSodium channelsRenal sodium excretionGlomerular filtration rateSerum potassium levelsSerum potassium concentrationNormal rat chowSprague-Dawley ratsRenal distal tubulesPotassium concentrationKidney distal tubuleMembrane sodium channelsResetting of tubuloglomerular feedback by interrupting early distal flow
MORSING P, VELAZQUEZ H, ELLISON D, WRIGHT FS. Resetting of tubuloglomerular feedback by interrupting early distal flow. Acta Physiologica 1993, 148: 63-68. PMID: 8333296, DOI: 10.1111/j.1748-1716.1993.tb09532.x.Peer-Reviewed Original ResearchConceptsAfferent arteriolesMacula densaTGF mechanismDistal tubulesDistal nephronMacula densa segmentStop-flow pressureTubuloglomerular feedback mechanismHalf-maximal decreaseMacula densa plaqueDelta PsfGlomerular arteriolesTubuloglomerular feedbackDistal flowExtraglomerular mesangiumGlomerular dynamicsSame nephronTubular fluidTubular segmentsOrthograde microperfusionArteriolesNephronSignificant increaseBlockadeConcentration of sodium
1992
Luminal influences on potassium secretion: chloride, sodium, and thiazide diuretics
Velazquez H, Ellison DH, Wright FS. Luminal influences on potassium secretion: chloride, sodium, and thiazide diuretics. American Journal Of Physiology 1992, 262: f1076-f1082. PMID: 1621812, DOI: 10.1152/ajprenal.1992.262.6.f1076.Peer-Reviewed Original ResearchActive potassium absorption by the renal distal tubule
Okusa MD, Unwin RJ, Velazquez H, Giebisch G, Wright FS. Active potassium absorption by the renal distal tubule. American Journal Of Physiology 1992, 262: f488-f493. PMID: 1532693, DOI: 10.1152/ajprenal.1992.262.3.f488.Peer-Reviewed Original ResearchConceptsDistal tubulesPotassium-deficient ratsLumen-negative transepithelial voltageLow potassium dietSprague-Dawley ratsRenal distal tubulesRat distal tubulesGroups of ratsLate distal tubuleSCH 28080Vivo microperfusion techniquesNet potassium fluxActive potassium absorptionK-adenosinetriphosphataseRegular dietPotassium absorptionNormal ratsDistal nephronPotassium depletionRatsSmall hyperpolarizationMicroperfusion techniquePotassium homeostasisTransepithelial voltageActive transport mechanism
1991
Adaptation of distal convoluted tubule of rats. II. Effects of chronic thiazide infusion
Morsing P, Velazquez H, Wright FS, Ellison DH. Adaptation of distal convoluted tubule of rats. II. Effects of chronic thiazide infusion. American Journal Of Physiology 1991, 261: f137-f143. PMID: 1858894, DOI: 10.1152/ajprenal.1991.261.1.f137.Peer-Reviewed Original ResearchConceptsDistal tubulesDistal tubule cellsTubule cellsThiazide-sensitive transportersFree-flow micropunctureVehicle-treated animalsDistal convoluted tubuleRenal cortical membranesReceptor binding studiesHigh-affinity receptorPmol/minIntrinsic transport capacityMammalian distal tubuleHCTZ groupChronic blockadeChronic administrationDirect functional measurementsCortical membranesConvoluted tubulesOsmotic pumpThiazide receptorCl deliveryTubule fluidApical membraneHydrochlorothiazide