Renal mechanism of trimethoprim-induced hyperkalemia.
Velázquez H, Perazella MA, Wright FS, Ellison DH. Renal mechanism of trimethoprim-induced hyperkalemia. Annals Of Internal Medicine 1993, 119: 296-301. PMID: 8328738, DOI: 10.7326/0003-4819-119-4-199308150-00008.Peer-Reviewed Original ResearchConceptsRenal potassium excretionPotassium excretionMammalian distal nephronDistal tubulesTrimethoprim therapyPotassium secretionDistal nephronMale Sprague-Dawley ratsLumen-negative transepithelial voltageTransepithelial voltageNormal adrenocortical functionSeverity of hyperkalemiaTranstubular potassium gradientUrine electrolyte levelsSodium channelsRenal sodium excretionGlomerular filtration rateSerum potassium levelsSerum potassium concentrationNormal rat chowSprague-Dawley ratsRenal distal tubulesPotassium concentrationKidney distal tubuleMembrane sodium channelsResetting of tubuloglomerular feedback by interrupting early distal flow
MORSING P, VELAZQUEZ H, ELLISON D, WRIGHT FS. Resetting of tubuloglomerular feedback by interrupting early distal flow. Acta Physiologica 1993, 148: 63-68. PMID: 8333296, DOI: 10.1111/j.1748-1716.1993.tb09532.x.Peer-Reviewed Original ResearchConceptsAfferent arteriolesMacula densaTGF mechanismDistal tubulesDistal nephronMacula densa segmentStop-flow pressureTubuloglomerular feedback mechanismHalf-maximal decreaseMacula densa plaqueDelta PsfGlomerular arteriolesTubuloglomerular feedbackDistal flowExtraglomerular mesangiumGlomerular dynamicsSame nephronTubular fluidTubular segmentsOrthograde microperfusionArteriolesNephronSignificant increaseBlockadeConcentration of sodium