Renal mechanism of trimethoprim-induced hyperkalemia.
Velázquez H, Perazella MA, Wright FS, Ellison DH. Renal mechanism of trimethoprim-induced hyperkalemia. Annals Of Internal Medicine 1993, 119: 296-301. PMID: 8328738, DOI: 10.7326/0003-4819-119-4-199308150-00008.Peer-Reviewed Original ResearchConceptsRenal potassium excretionPotassium excretionMammalian distal nephronDistal tubulesTrimethoprim therapyPotassium secretionDistal nephronMale Sprague-Dawley ratsLumen-negative transepithelial voltageTransepithelial voltageNormal adrenocortical functionSeverity of hyperkalemiaTranstubular potassium gradientUrine electrolyte levelsSodium channelsRenal sodium excretionGlomerular filtration rateSerum potassium levelsSerum potassium concentrationNormal rat chowSprague-Dawley ratsRenal distal tubulesPotassium concentrationKidney distal tubuleMembrane sodium channels