Adaptation of distal convoluted tubule of rats. II. Effects of chronic thiazide infusion
Morsing P, Velazquez H, Wright FS, Ellison DH. Adaptation of distal convoluted tubule of rats. II. Effects of chronic thiazide infusion. American Journal Of Physiology 1991, 261: f137-f143. PMID: 1858894, DOI: 10.1152/ajprenal.1991.261.1.f137.Peer-Reviewed Original ResearchConceptsDistal tubulesDistal tubule cellsTubule cellsThiazide-sensitive transportersFree-flow micropunctureVehicle-treated animalsDistal convoluted tubuleRenal cortical membranesReceptor binding studiesHigh-affinity receptorPmol/minIntrinsic transport capacityMammalian distal tubuleHCTZ groupChronic blockadeChronic administrationDirect functional measurementsCortical membranesConvoluted tubulesOsmotic pumpThiazide receptorCl deliveryTubule fluidApical membraneHydrochlorothiazide