1999
Gramicidin channel controversy — the structure in a lipid environment
Andersen O, Apell H, Bamberg E, Busath D, Koeppe R, Sigworth F, Szabo G, Urry D, Woolley A. Gramicidin channel controversy — the structure in a lipid environment. Nature Structural & Molecular Biology 1999, 6: 609-609. PMID: 10404209, DOI: 10.1038/10648.Peer-Reviewed Original Research
1998
Activation of Shaker Potassium Channels
Schoppa N, Sigworth F. Activation of Shaker Potassium Channels. The Journal Of General Physiology 1998, 111: 295-311. PMID: 9450945, PMCID: PMC2222768, DOI: 10.1085/jgp.111.2.295.Peer-Reviewed Original ResearchActivation of Shaker Potassium Channels
Schoppa N, Sigworth F. Activation of Shaker Potassium Channels. The Journal Of General Physiology 1998, 111: 313-342. PMID: 9450946, PMCID: PMC2222769, DOI: 10.1085/jgp.111.2.313.Peer-Reviewed Original Research
1995
Design of the EPC-9, a computer-controlled patch-clamp amplifier. 1. Hardware
Sigworth F. Design of the EPC-9, a computer-controlled patch-clamp amplifier. 1. Hardware. Journal Of Neuroscience Methods 1995, 56: 195-202. PMID: 7538620, DOI: 10.1016/0165-0270(94)00128-4.Peer-Reviewed Original ResearchDesign of the EPC-9, a computer-controlled patch-clamp amplifier. 2. Software
Sigworth F, Affolter H, Neher E. Design of the EPC-9, a computer-controlled patch-clamp amplifier. 2. Software. Journal Of Neuroscience Methods 1995, 56: 203-215. PMID: 7538621, DOI: 10.1016/0165-0270(94)00129-5.Peer-Reviewed Original Research
1994
Voltage gating of ion channels
Sigworth F. Voltage gating of ion channels. Quarterly Reviews Of Biophysics 1994, 27: 1-40. PMID: 7520590, DOI: 10.1017/s0033583500002894.Peer-Reviewed Original ResearchConceptsVoltage-gated calcium channelsNerve action potentialsVoltage-gated sodium channelsRelease of hormonesIon channelsVoltage-gated ion channelsCalcium channelsAction potentialsNeurotransmitter releaseMuscle contractionSodium channelsMembrane proteinsCellular signalsVoltage gatingCentral roleHormoneRelease
1992
[52] Analysis of nonstationary single-channel currents
Sigworth F, Zhou J. [52] Analysis of nonstationary single-channel currents. Methods In Enzymology 1992, 207: 746-762. PMID: 1382211, DOI: 10.1016/0076-6879(92)07054-r.Peer-Reviewed Original Research
1991
Open channel noise. VI. Analysis of amplitude histograms to determine rapid kinetic parameters
Heinemann S, Sigworth F. Open channel noise. VI. Analysis of amplitude histograms to determine rapid kinetic parameters. Biophysical Journal 1991, 60: 577-587. PMID: 1718467, PMCID: PMC1260101, DOI: 10.1016/s0006-3495(91)82087-2.Peer-Reviewed Original Research
1990
Yet another approach to the dwell-time omission problem of single-channel analysis
Crouzy S, Sigworth F. Yet another approach to the dwell-time omission problem of single-channel analysis. Biophysical Journal 1990, 58: 731-743. PMID: 1698473, PMCID: PMC1281014, DOI: 10.1016/s0006-3495(90)82416-4.Peer-Reviewed Original ResearchActivation of Torpedo acetylcholine receptors expressed in mouse fibroblasts. Single channel current kinetics reveal distinct agonist binding affinities.
Sine S, Claudio T, Sigworth F. Activation of Torpedo acetylcholine receptors expressed in mouse fibroblasts. Single channel current kinetics reveal distinct agonist binding affinities. The Journal Of General Physiology 1990, 96: 395-437. PMID: 1698917, PMCID: PMC2228994, DOI: 10.1085/jgp.96.2.395.Peer-Reviewed Original ResearchOpen channel noise. V. Fluctuating barriers to ion entry in gramicidin A channels
Heinemann S, Sigworth F. Open channel noise. V. Fluctuating barriers to ion entry in gramicidin A channels. Biophysical Journal 1990, 57: 499-514. PMID: 1689592, PMCID: PMC1280744, DOI: 10.1016/s0006-3495(90)82566-2.Peer-Reviewed Original Research
1989
Estimation of Na+ dwell time in the gramicidin A channel. Na+ ions as blockers of H+ currents
Heinemann S, Sigworth F. Estimation of Na+ dwell time in the gramicidin A channel. Na+ ions as blockers of H+ currents. Biochimica Et Biophysica Acta 1989, 987: 8-14. PMID: 2480817, DOI: 10.1016/0005-2736(89)90448-3.Peer-Reviewed Original ResearchTransmembrane Channels Based on Tartaric Acid-Gramicidin A Hybrids
Stankovic C, Heinemann S, Delfino J, Sigworth F, Schreiber S. Transmembrane Channels Based on Tartaric Acid-Gramicidin A Hybrids. Science 1989, 244: 813-817. PMID: 2471263, DOI: 10.1126/science.2471263.Peer-Reviewed Original Research
1988
Open channel noise. IV. Estimation of rapid kinetics of formamide block in gramicidin A channels
Heinemann S, Sigworth F. Open channel noise. IV. Estimation of rapid kinetics of formamide block in gramicidin A channels. Biophysical Journal 1988, 54: 757-764. PMID: 2465033, PMCID: PMC1330382, DOI: 10.1016/s0006-3495(88)83013-3.Peer-Reviewed Original ResearchMeSH KeywordsElectric ConductivityFormamidesGramicidinIon ChannelsKineticsMathematicsMembrane PotentialsModels, BiologicalConceptsBiological ion channelsGramicidin A channelsTime resolutionCurrent histogramFast time scaleOpen channel noiseCharacteristic timeNoise measurementsSingle-channel experimentsNoise experimentsDirect measurementTime scalesA channelsSpectral densityBandwidth limitationsCurrentTheoretical approachMeasurementsIon channelsBlocking processChannelsSingle-channel recordingsSingle-channel currentsNoiseDependence
1987
Open channel noise. III. High-resolution recordings show rapid current fluctuations in gramicidin A and four chemical analogues
Sigworth F, Urry D, Prasad K. Open channel noise. III. High-resolution recordings show rapid current fluctuations in gramicidin A and four chemical analogues. Biophysical Journal 1987, 52: 1055-1064. PMID: 2447969, PMCID: PMC1330105, DOI: 10.1016/s0006-3495(87)83299-x.Peer-Reviewed Original ResearchData transformations for improved display and fitting of single-channel dwell time histograms
Sigworth F, Sine S. Data transformations for improved display and fitting of single-channel dwell time histograms. Biophysical Journal 1987, 52: 1047-1054. PMID: 2447968, PMCID: PMC1330104, DOI: 10.1016/s0006-3495(87)83298-8.Peer-Reviewed Original Research
1986
Open channel noise. II. A test for coupling between current fluctuations and conformational transitions in the acetylcholine receptor
Sigworth F. Open channel noise. II. A test for coupling between current fluctuations and conformational transitions in the acetylcholine receptor. Biophysical Journal 1986, 49: 1041-1046. PMID: 2423148, PMCID: PMC1329684, DOI: 10.1016/s0006-3495(86)83732-8.Peer-Reviewed Original Research
1981
Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches
Hamill O, Marty A, Neher E, Sakmann B, Sigworth F. Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches. Pflügers Archiv - European Journal Of Physiology 1981, 391: 85-100. PMID: 6270629, DOI: 10.1007/bf00656997.Peer-Reviewed Original Research
1980
The variance of sodium current fluctuations at the node of Ranvier
Sigworth F. The variance of sodium current fluctuations at the node of Ranvier. The Journal Of Physiology 1980, 307: 97-129. PMID: 6259340, PMCID: PMC1283036, DOI: 10.1113/jphysiol.1980.sp013426.Peer-Reviewed Original ResearchSingle Na+ channel currents observed in cultured rat muscle cells
Sigworth F, Neher E. Single Na+ channel currents observed in cultured rat muscle cells. Nature 1980, 287: 447-449. PMID: 6253802, DOI: 10.1038/287447a0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedElectric ConductivityIon ChannelsMembrane PotentialsMicroelectrodesMusclesRatsSodium