2016
Statistical modeling and removal of lipid membrane projections for cryo-EM structure determination of reconstituted membrane proteins
Jensen KH, Brandt SS, Shigematsu H, Sigworth FJ. Statistical modeling and removal of lipid membrane projections for cryo-EM structure determination of reconstituted membrane proteins. Journal Of Structural Biology 2016, 194: 49-60. PMID: 26835990, PMCID: PMC4866491, DOI: 10.1016/j.jsb.2016.01.012.Peer-Reviewed Original Research
2013
Quantifying the local resolution of cryo-EM density maps
Kucukelbir A, Sigworth FJ, Tagare HD. Quantifying the local resolution of cryo-EM density maps. Nature Methods 2013, 11: 63-65. PMID: 24213166, PMCID: PMC3903095, DOI: 10.1038/nmeth.2727.Peer-Reviewed Original Research
2002
Applying Hidden Markov Models to the Analysis of Single Ion Channel Activity
Venkataramanan L, Sigworth F. Applying Hidden Markov Models to the Analysis of Single Ion Channel Activity. Biophysical Journal 2002, 82: 1930-1942. PMID: 11916851, PMCID: PMC1301989, DOI: 10.1016/s0006-3495(02)75542-2.Peer-Reviewed Original ResearchConceptsCorrelated background noiseHidden Markov ModelDigital inverse filterMarkov model parametersDiscrete timeBaum-Welch algorithmMarkov modelComputational intensityDeterministic interferenceModel parametersInverse filterMultiple data setsAlgorithmPrevious resultsPractical applicationsNoise ratioState transitionsSharp frequencyData setsChannel dataSingle ion channel currentsNoiseExtensionRandomnessBackground noise