1989
Estimation of Na+ dwell time in the gramicidin A channel. Na+ ions as blockers of H+ currents
Heinemann S, Sigworth F. Estimation of Na+ dwell time in the gramicidin A channel. Na+ ions as blockers of H+ currents. Biochimica Et Biophysica Acta 1989, 987: 8-14. PMID: 2480817, DOI: 10.1016/0005-2736(89)90448-3.Peer-Reviewed Original Research
1980
The variance of sodium current fluctuations at the node of Ranvier
Sigworth F. The variance of sodium current fluctuations at the node of Ranvier. The Journal Of Physiology 1980, 307: 97-129. PMID: 6259340, PMCID: PMC1283036, DOI: 10.1113/jphysiol.1980.sp013426.Peer-Reviewed Original ResearchSingle Na+ channel currents observed in cultured rat muscle cells
Sigworth F, Neher E. Single Na+ channel currents observed in cultured rat muscle cells. Nature 1980, 287: 447-449. PMID: 6253802, DOI: 10.1038/287447a0.Peer-Reviewed Original ResearchChemical modification reduces the conductance of sodium channels in nerve
Sigworth F, Spalding B. Chemical modification reduces the conductance of sodium channels in nerve. Nature 1980, 283: 293-295. PMID: 6965422, DOI: 10.1038/283293a0.Peer-Reviewed Original ResearchConceptsChemical modificationTrimethyloxonium ionSuch chemical modificationsCarboxyl groupsNegative chargeSuch reagentsTMO treatmentPermeability propertiesReagentsLinear instantaneous current-voltage relationshipSmaller single-channel conductancePropertiesPotent poisonNormal KdIonsModificationSaxitoxinCharge
1977
Sodium channels in nerve apparently have two conductance states
SIGWORTH F. Sodium channels in nerve apparently have two conductance states. Nature 1977, 270: 265-267. PMID: 593345, DOI: 10.1038/270265a0.Peer-Reviewed Original Research