2015
Crystal structure of the eukaryotic origin recognition complex
Bleichert F, Botchan MR, Berger JM. Crystal structure of the eukaryotic origin recognition complex. Nature 2015, 519: 321-326. PMID: 25762138, PMCID: PMC4368505, DOI: 10.1038/nature14239.Peer-Reviewed Original ResearchConceptsOrigin recognition complexDrosophila origin recognition complexRecognition complexEukaryotic origin recognition complexHeterohexameric origin recognition complexMini-chromosome maintenance 2Winged-helix domainCatalytic amino acidsCellular DNA replicationWinged-helix foldORC subunitsEncircles DNAHelicase loadingGenomic integrityORC functionDevelopmental controlDNA replicationÅ resolutionDomain interactionsDisrupts interactionsCell cycleMaintenance 2Amino acidsCentral channelUnanticipated features
2009
A Dimeric Structure for Archaeal Box C/D Small Ribonucleoproteins
Bleichert F, Gagnon KT, Brown BA, Maxwell ES, Leschziner AE, Unger VM, Baserga SJ. A Dimeric Structure for Archaeal Box C/D Small Ribonucleoproteins. Science 2009, 325: 1384-1387. PMID: 19745151, PMCID: PMC2975540, DOI: 10.1126/science.1176099.Peer-Reviewed Original ResearchConceptsBox C/D sRNPArchaeal box C/D sRNPsRibosomal RNASingle-particle electron microscopyTarget ribosomal RNAArchaeon Methanocaldococcus jannaschiiOptimal protein synthesisRibose methylationMethanocaldococcus jannaschiiSmall ribonucleoproteinRNA componentEnzymatic functionSRNPDimeric structureMutational analysisProtein componentsProtein synthesisMethylationBase pairingRNAEukaryotesSnoRNPsArchaeaJannaschiiRibonucleoprotein