2006
Smoking is associated with increased telomerase activity in short-term cultures of human bronchial epithelial cells
Yim HW, Slebos RJ, Randell SH, Umbach DM, Parsons AM, Rivera MP, Detterbeck FC, Taylor JA. Smoking is associated with increased telomerase activity in short-term cultures of human bronchial epithelial cells. Cancer Letters 2006, 246: 24-33. PMID: 16517060, DOI: 10.1016/j.canlet.2006.01.023.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBronchiCell Culture TechniquesCell ProliferationCells, CulturedCellular SenescenceChildDNA MethylationEpithelial CellsFemaleHumansLung NeoplasmsMaleMiddle AgedPolymerase Chain ReactionPromoter Regions, GeneticSmokingTelomeraseTime FactorsTumor Cells, CulturedConceptsNormal bronchial epitheliumTelomeric repeat amplification protocolHuman bronchial epithelial cellsBronchial epithelial cellsBronchial epitheliumTelomerase activityLung cancer historyLung cancer statusEpithelial cellsMaximum passage numberTobacco carcinogen exposureHBE cell culturesRepeat amplification protocolExtended culturingHTERT promoterShort-term cultureSmoking historyTobacco smokingPassage numberCancer historyLung carcinogenesisLung carcinomaCancer statusCarcinogen exposureCausative role
2005
Chromosomal abnormalities in bronchial epithelium from smokers, nonsmokers, and lung cancer patients
Slebos RJ, Livanos E, Yim HW, Randell SH, Parsons AM, Detterbeck FC, Rivera MP, Taylor JA. Chromosomal abnormalities in bronchial epithelium from smokers, nonsmokers, and lung cancer patients. Cancer Genetics 2005, 159: 137-142. PMID: 15899385, DOI: 10.1016/j.cancergencyto.2004.10.008.Peer-Reviewed Original ResearchConceptsLung cancer patientsCancer patientsNon-lung cancer patientsAbnormal metaphasesChromosomal abnormalitiesHistory of smokingTobacco smoke exposureBronchial epithelial cell culturesHBE cell culturesCell culturesHuman bronchial epithelial cell culturesTobacco smokingSmoke exposureLung cancerEarly treatmentBronchial epitheliumCancer riskIdentification of individualsEpithelial cell culturesPatientsNonsmokersUseful markerGreater riskSmokersObserved abnormalities