2021
The 2021 WHO Classification of Tumors of the Thymus and Mediastinum: What Is New in Thymic Epithelial, Germ Cell, and Mesenchymal Tumors?
Marx A, Chan JKC, Chalabreysse L, Dacic S, Detterbeck F, French CA, Hornick JL, Inagaki H, Jain D, Lazar AJ, Marino M, Marom EM, Moreira AL, Nicholson AG, Noguchi M, Nonaka D, Papotti MG, Porubsky S, Sholl LM, Tateyama H, Thomas de Montpréville V, Travis WD, Rajan A, Roden AC, Ströbel P. The 2021 WHO Classification of Tumors of the Thymus and Mediastinum: What Is New in Thymic Epithelial, Germ Cell, and Mesenchymal Tumors? Journal Of Thoracic Oncology 2021, 17: 200-213. PMID: 34695605, DOI: 10.1016/j.jtho.2021.10.010.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaGerm CellsHumansLung NeoplasmsMediastinumThymus NeoplasmsWorld Health OrganizationConceptsThymic epithelial tumorsGerm cell tumorsCell tumorsMesenchymal neoplasmsWHO classificationEpithelial tumorsMediastinal germ cell tumorsLow tumor mutational burdenTumor mutational burdenNew tumor entityClear cell carcinomaPositron emission tomographyClassification of tumorsThymic EpithelialThymic carcinomaFifth editionB3 thymomaTargetable mutationsCell carcinomaMesenchymal tumorsMetaplastic thymomaImmunohistochemical characterizationClinical informationMutational burdenDiagnostic advancesRates of invasive disease and outcomes in NSCLC patients with biopsy suggestive of carcinoma in situ
Talcott WJ, Miccio JA, Park HS, White AA, Kozono DE, Singer L, Sands JM, Sholl LM, Detterbeck FC, Mak RH, Decker RH, Kann BH. Rates of invasive disease and outcomes in NSCLC patients with biopsy suggestive of carcinoma in situ. Lung Cancer 2021, 157: 17-20. PMID: 34052704, DOI: 10.1016/j.lungcan.2021.05.028.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerBiopsy suggestiveInvasive diseaseSitu diseaseSquamous histologySurvival outcomesTumor sizeObserved cohortNational Cancer DatabaseExcellent survival outcomesHalf of patientsCell lung cancerMultivariable logistic regressionResection of lesionsAdenocarcinoma histologyDefinitive therapyNSCLC patientsOverall survivalLocal therapyRisk stratificationLung cancerCancer DatabaseResectionSurgical pathologyLesion size
2017
“What if I do nothing?” The natural history of operable cancer of the alimentary tract
Keshava HB, Rosen JE, DeLuzio MR, Kim AW, Detterbeck FC, Boffa DJ. “What if I do nothing?” The natural history of operable cancer of the alimentary tract. European Journal Of Surgical Oncology 2017, 43: 788-795. PMID: 28131669, DOI: 10.1016/j.ejso.2016.12.006.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overCarcinoma, Signet Ring CellCarcinoma, Squamous CellColonic NeoplasmsDatabases, FactualDisease ProgressionEsophageal NeoplasmsFemaleGastrointestinal NeoplasmsHumansMaleMiddle AgedNeoplasm StagingRectal NeoplasmsStomach NeoplasmsSurvival RateUnited StatesWatchful WaitingConceptsAlimentary tract cancersTract cancerNatural historyUntreated patientsCancer surgeryClinical stage IStage-specific survivalOperable cancerInoperable patientsMedian survivalRectal cancerClinical stagePreoperative counselingPatientsStage ISurgeryCancerPoor healthAlimentary tractSurvivalHealth reasonsStudy objectiveTreatmentCIICIII
2016
Timing of Surgery after Neoadjuvant Chemoradiation in Locally Advanced Non–Small Cell Lung Cancer
Gao SJ, Corso CD, Wang EH, Blasberg JD, Detterbeck FC, Boffa DJ, Decker RH, Kim AW. Timing of Surgery after Neoadjuvant Chemoradiation in Locally Advanced Non–Small Cell Lung Cancer. Journal Of Thoracic Oncology 2016, 12: 314-322. PMID: 27720827, DOI: 10.1016/j.jtho.2016.09.122.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaCarcinoma, Large CellCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellChemoradiotherapy, AdjuvantCombined Modality TherapyFemaleFollow-Up StudiesHumansLung NeoplasmsMaleMiddle AgedNeoadjuvant TherapyNeoplasm StagingPneumonectomyPrognosisRetrospective StudiesSurvival RateTime FactorsConceptsNational Cancer Data BaseNeoadjuvant chemoradiationTiming of surgeryOverall survivalAdvanced non-small cell lung cancerNon-small cell lung cancerStage IIIA-N2 NSCLCStage IIIA NSCLCKaplan-Meier methodOverall survival rateSubset of patientsCell lung cancerLog-rank testMultivariate survival analysisProportional hazards modelIIIA NSCLCN2 NSCLCNeoadjuvant therapyTrimodality therapySurgical resectionClinical stageRetrospective studyLung cancerHazards modelSurvival rateThe IASLC Lung Cancer Staging Project: Proposals for Coding T Categories for Subsolid Nodules and Assessment of Tumor Size in Part-Solid Tumors in the Forthcoming Eighth Edition of the TNM Classification of Lung Cancer
Travis WD, Asamura H, Bankier AA, Beasley MB, Detterbeck F, Flieder DB, Goo JM, MacMahon H, Naidich D, Nicholson AG, Powell CA, Prokop M, Rami-Porta R, Rusch V, van Schil P, Yatabe Y, Members I, Goldstraw P, Rami-Porta R, Asamura H, Ball D, Beer D, Beyruti R, Bolejack V, Chansky K, Crowley J, Detterbeck F, Eberhardt W, Edwards J, Galateau-Sallé F, Giroux D, Gleeson F, Groome P, Huang J, Kennedy C, Kim J, Kim Y, Kingsbury L, Kondo H, Krasnik M, Kubota K, Lerut A, Lyons G, Marino M, Marom E, van Meerbeeck J, Mitchell A, Nakano T, Nicholson A, Nowak A, Peake M, Rice T, Rosenzweig K, Ruffini E, Rusch V, Saijo N, Van Schil P, Sculier J, Shemanski L, Stratton K, Suzuki K, Tachimori Y, Thomas C, Travis W, Tsao M, Turrisi A, Vansteenkiste J, Watanabe H, Wu Y, Baas P, Erasmus J, Hasegawa S, Inai K, Kernstine K, Kindler H, Krug L, Nackaerts K, Pass H, Rice D, Falkson C, Filosso P, Giaccone G, Kondo K, Lucchi M, Okumura M, Blackstone E. The IASLC Lung Cancer Staging Project: Proposals for Coding T Categories for Subsolid Nodules and Assessment of Tumor Size in Part-Solid Tumors in the Forthcoming Eighth Edition of the TNM Classification of Lung Cancer. Journal Of Thoracic Oncology 2016, 11: 1204-1223. PMID: 27107787, DOI: 10.1016/j.jtho.2016.03.025.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdenocarcinoma in SituAdenocarcinoma of LungHumansLung NeoplasmsNeoplasm StagingTomography, X-Ray ComputedConceptsPart-solid tumorsLepidic predominant adenocarcinomaTumor sizeLung cancerInternational Cancer Control tumorEighth editionWorld Health Organization classificationIASLC Lung Cancer Staging ProjectLung Cancer Staging ProjectForthcoming Eighth EditionNonmucinous lung adenocarcinomasPrimary tumor categoryComputed tomography findingsInvasive mucinous adenocarcinomaSquamous cell carcinomaGround-glass componentInvasive sizeTomography findingsClinical stagingMucinous adenocarcinomaPathologic evaluationResected specimensTNM classificationCell carcinomaMetastasis classificationThe IASLC Lung Cancer Staging Project: Background Data and Proposals for the Application of TNM Staging Rules to Lung Cancer Presenting as Multiple Nodules with Ground Glass or Lepidic Features or a Pneumonic Type of Involvement in the Forthcoming Eighth Edition of the TNM Classification
Detterbeck FC, Marom EM, Arenberg DA, Franklin WA, Nicholson AG, Travis WD, Girard N, Mazzone PJ, Donington JS, Tanoue LT, Rusch VW, Asamura H, Rami-Porta R, Committee I, Goldstraw P, Rami-Porta R, Asamura H, Ball D, Beer D, Beyruti R, Bolejack V, Chansky K, Crowley J, Detterbeck F, Eberhardt W, Edwards J, Galateau-Sallé F, Giroux D, Gleeson F, Groome P, Huang J, Kennedy C, Kim J, Kim Y, Kingsbury L, Kondo H, Krasnik M, Kubota K, Lerut A, Lyons G, Marino M, Marom E, van Meerbeeck J, Mitchell A, Nakano T, Nicholson A, Nowak A, Peake M, Rice T, Rosenzweig K, Ruffini E, Rusch V, Saijo N, Van Schil P, Sculier J, Shemanski L, Stratton K, Suzuki K, Tachimori Y, Thomas C, Travis W, Tsao M, Turrisi A, Vansteenkiste J, Watanabe H, Wu Y, Boards A, Baas P, Erasmus J, Hasegawa S, Inai K, Kernstine K, Kindler H, Krug L, Nackaerts K, Pass H, Rice D, Falkson C, Filosso P, Giaccone G, Kondo K, Lucchi M, Okumura M, Blackstone E, Workgroup M, Flieder D, Godoy M, Goo J, Goodman L, Jett J, de Leyn P, Marchevsky A, MacMahon H, Naidich D, Okada M, Perlman M, Powell C, van Schil P, Warth A. The IASLC Lung Cancer Staging Project: Background Data and Proposals for the Application of TNM Staging Rules to Lung Cancer Presenting as Multiple Nodules with Ground Glass or Lepidic Features or a Pneumonic Type of Involvement in the Forthcoming Eighth Edition of the TNM Classification. Journal Of Thoracic Oncology 2016, 11: 666-680. PMID: 26940527, DOI: 10.1016/j.jtho.2015.12.113.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaHumansLung NeoplasmsMeta-Analysis as TopicNeoplasm StagingNeoplasms, Second PrimaryPrognosisConceptsForthcoming Eighth EditionTNM classificationLung cancerT categoryM categoryMultiple ground-glass nodulesEighth editionIASLC Lung Cancer Staging ProjectLung Cancer Staging ProjectIpsilateral different lobeLung Cancer PresentingLung cancer stagingNumber of tumorsGround-glass componentApplication of tumorGround-glass nodulesPrognostic Factors CommitteePneumonic typeExtrathoracic metastasesDistant metastasisMultiple nodulesWorse prognosisMetastasis classificationMultifocal natureLepidic componentThe IASLC Lung Cancer Staging Project: Summary of Proposals for Revisions of the Classification of Lung Cancers with Multiple Pulmonary Sites of Involvement in the Forthcoming Eighth Edition of the TNM Classification
Detterbeck FC, Nicholson AG, Franklin WA, Marom EM, Travis WD, Girard N, Arenberg DA, Bolejack V, Donington JS, Mazzone PJ, Tanoue LT, Rusch VW, Crowley J, Asamura H, Rami-Porta R, Committee I, Goldstraw P, Rami-Porta R, Asamura H, Ball D, Beer D, Beyruti R, Bolejack V, Chansky K, Crowley J, Detterbeck F, Eberhardt W, Edwards J, Galateau-Sallé F, Giroux D, Gleeson F, Groome P, Huang J, Kennedy C, Kim J, Kim Y, Kingsbury L, Kondo H, Krasnik M, Kubota K, Lerut A, Lyons G, Marino M, Marom E, van Meerbeeck J, Mitchell A, Nakano T, Nicholson A, Nowak A, Peake M, Rice T, Rosenzweig K, Ruffini E, Rusch V, Saijo N, Van Schil P, Sculier J, Shemanski L, Stratton K, Suzuki K, Tachimori Y, Thomas C, Travis W, Tsao M, Turrisi A, Vansteenkiste J, Watanabe H, Wu Y, Boards A, Baas P, Erasmus J, Hasegawa S, Inai K, Kernstine K, Kindler H, Krug L, Nackaerts K, Pass H, Rice D, Falkson C, Filosso P, Giaccone G, Kondo K, Lucchi M, Okumura M, Blackstone E, Workgroup M, Flieder D, Godoy M, Goo J, Goodman L, Jett J, de Leyn P, Marchevsky A, MacMahon H, Naidich D, Okada M, Perlman M, Powell C, van Schil P, Warth A, Institutions P, Cavaco F, Barrera E, Arca J, Lamelas I, Obrer A, Jorge R, Ball D, Bascom G, Orozco A, Castro M, Blum M, Chimondeguy D, Cvijanovic V, Defranchi S, de Olaiz Navarro B, Campuzano I, Vidueira I, Araujo E, García F, Fong K, Corral G, González S, Gilart J, Arangüena L, Barajas S, Girard P, Goksel T, Budiño M, Casaurrán G, Blanco J, Hernández J, Rodríguez H, Collantes J, Heras M, Elena J, Jakobsen E, Kostas S, Atance P, Ares A, Liao M, Losanovscky M, Lyons G, Magaroles R, De Esteban Júlvez L, Gorospe M, McCaughan B, Kennedy C, Íñiguez R, Sorribes L, Gozalo S, de Arriba C, Delgado M, Alarcón J, Cuesta J, Park J, Pass H, Fernández M, Rosenberg M, Ruffini E, Rusch V, de Cos Escuín J, Vinuesa A, Mitjans M, Strand T, Subotic D, Swisher S, Terra R, Thomas C, Tournoy K, Van Schil P, Velasquez M, Wu Y, Yokoi K. The IASLC Lung Cancer Staging Project: Summary of Proposals for Revisions of the Classification of Lung Cancers with Multiple Pulmonary Sites of Involvement in the Forthcoming Eighth Edition of the TNM Classification. Journal Of Thoracic Oncology 2016, 11: 639-650. PMID: 26940528, DOI: 10.1016/j.jtho.2016.01.024.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaHumansLung NeoplasmsMeta-Analysis as TopicNeoplasm StagingNeoplasms, Second PrimaryPrognosisConceptsMultiple pulmonary sitesLung cancerPulmonary sitesM categoryTNM classificationSecond primary lung cancerEighth editionIASLC Lung Cancer Staging ProjectLung Cancer Staging ProjectForthcoming Eighth EditionSame histologic typePrimary lung cancerLung cancer stagingLung cancer databaseSeparate tumor nodulesArea of involvementPatterns of diseasePrognostic Factors CommitteeClinical presentationHistologic typePathologic correlatesMetastasis classificationOptimal treatmentT categoryCancer DatabaseThe IASLC Lung Cancer Staging Project: Background Data and Proposals for the Classification of Lung Cancer with Separate Tumor Nodules in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer
Detterbeck FC, Bolejack V, Arenberg DA, Crowley J, Donington JS, Franklin WA, Girard N, Marom EM, Mazzone PJ, Nicholson AG, Rusch VW, Tanoue LT, Travis WD, Asamura H, Rami-Porta R, Committee I, Goldstraw P, Rami-Porta R, Asamura H, Ball D, Beer D, Beyruti R, Bolejack V, Chansky K, Crowley J, Detterbeck F, Eberhardt W, Edwards J, Galateau-Sallé F, Giroux D, Gleeson F, Groome P, Huang J, Kennedy C, Kim J, Kim Y, Kingsbury L, Kondo H, Krasnik M, Kubota K, Lerut A, Lyons G, Marino M, Marom E, van Meerbeeck J, Mitchell A, Nakano T, Nicholson A, Nowak A, Peake M, Rice T, Rosenzweig K, Ruffini E, Rusch V, Saijo N, Van Schil P, Sculier J, Shemanski L, Stratton K, Suzuki K, Tachimori Y, Thomas C, Travis W, Tsao M, Turrisi A, Vansteenkiste J, Watanabe H, Wu Y, Boards A, Baas P, Erasmus J, Hasegawa S, Inai K, Kernstine K, Kindler H, Krug L, Nackaerts K, Pass H, Rice D, Falkson C, Filosso P, Giaccone G, Kondo K, Lucchi M, Okumura M, Blackstone E, Workgroup M, Flieder D, Godoy M, Goo J, Goodman L, Jett J, de Leyn P, Marchevsky A, MacMahon H, Naidich D, Okada M, Perlman M, Powell C, van Schil P, Warth A, Institutions P, Cavaco F, Barrera E, Arca J, Lamelas I, Obrer A, Jorge R, Ball D, Bascom G, Orozco A, Castro M, Blum M, Chimondeguy D, Cvijanovic V, Defranchi S, de Olaiz Navarro B, Campuzano I, Vidueira I, Araujo E, García F, Fong K, Corral G, González S, Gilart J, Arangüena L, Barajas S, Girard P, Goksel T, Budiño M, Casaurrán G, Blanco J, Hernández J, Rodríguez H, Collantes J, Heras M, Elena J, Jakobsen E, Kostas S, Atance P, Ares A, Liao M, Losanovscky M, Lyons G, Magaroles R, De Esteban Júlvez L, Gorospe M, McCaughan B, Kennedy C, Íñiguez R, Sorribes L, Gozalo S, de Arriba C, Delgado M, Alarcón J, Cuesta J, Park J, Pass H, Fernández M, Rosenberg M, Ruffini E, Rusch V, de Cos Escuín J, Vinuesa A, Mitjans M, Strand T, Subotic D, Swisher S, Terra R, Thomas C, Tournoy K, Van Schil P, Velasquez M, Wu Y, Yokoi K. The IASLC Lung Cancer Staging Project: Background Data and Proposals for the Classification of Lung Cancer with Separate Tumor Nodules in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer. Journal Of Thoracic Oncology 2016, 11: 681-692. PMID: 26940530, DOI: 10.1016/j.jtho.2015.12.114.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaHumansLung NeoplasmsMeta-Analysis as TopicNeoplasm StagingNeoplasms, Second PrimaryPrognosisSurvival RateConceptsSeparate tumor nodulesPrimary lung cancerLung cancerTumor nodulesEighth editionTNM classificationSurvival differencesSecond primary lung cancerIASLC Lung Cancer Staging ProjectLung Cancer Staging ProjectForthcoming Eighth EditionSame histologic appearanceProportion of patientsSurvival of patientsLung cancer databaseT3 tumorsT4 tumorsIndex tumorCancer DatabaseSuch tumorsHistologic appearanceAnatomic classificationPatientsTumorsCancerThe IASLC Lung Cancer Staging Project: Background Data and Proposed Criteria to Distinguish Separate Primary Lung Cancers from Metastatic Foci in Patients with Two Lung Tumors in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer
Detterbeck FC, Franklin WA, Nicholson AG, Girard N, Arenberg DA, Travis WD, Mazzone PJ, Marom EM, Donington JS, Tanoue LT, Rusch VW, Asamura H, Rami-Porta R, Committee I, Goldstraw P, Rami-Porta R, Asamura H, Ball D, Beer D, Beyruti R, Bolejack V, Chansky K, Crowley J, Detterbeck F, Eberhardt W, Edwards J, Galateau-Sallé F, Giroux D, Gleeson F, Groome P, Huang J, Kennedy C, Kim J, Kim Y, Kingsbury L, Kondo H, Krasnik M, Kubota K, Lerut A, Lyons G, Marino M, Marom E, van Meerbeeck J, Mitchell A, Nakano T, Nicholson A, Nowak A, Peake M, Rice T, Rosenzweig K, Ruffini E, Rusch V, Saijo N, Van Schil P, Sculier J, Shemanski L, Stratton K, Suzuki K, Tachimori Y, Thomas C, Travis W, Tsao M, Turrisi A, Vansteenkiste J, Watanabe H, Wu Y, Boards A, Baas P, Erasmus J, Hasegawa S, Inai K, Kernstine K, Kindler H, Krug L, Nackaerts K, Pass H, Rice D, Falkson C, Filosso P, Giaccone G, Kondo K, Lucchi M, Okumura M, Blackstone E, Workgroup M, Flieder D, Godoy M, Goo J, Goodman L, Jett J, de Leyn P, Marchevsky A, MacMahon H, Naidich D, Okada M, Perlman M, Powell C, van Schil P, Warth A. The IASLC Lung Cancer Staging Project: Background Data and Proposed Criteria to Distinguish Separate Primary Lung Cancers from Metastatic Foci in Patients with Two Lung Tumors in the Forthcoming Eighth Edition of the TNM Classification for Lung Cancer. Journal Of Thoracic Oncology 2016, 11: 651-665. PMID: 26944304, DOI: 10.1016/j.jtho.2016.01.025.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaHumansLung NeoplasmsMeta-Analysis as TopicNeoplasm StagingNeoplasms, Second PrimaryPrognosisConceptsPrimary lung cancerSecond primary lung cancerSeparate primary lung cancersLung cancerIASLC Lung Cancer Staging ProjectLung Cancer Staging ProjectForthcoming Eighth EditionOutcomes of patientsMultidisciplinary tumor boardLung cancer stagingComprehensive histologic assessmentHistologic cancer typesAbsence of biomarkersMechanisms of metastasisPrognostic Factors CommitteeNodal involvementTNM classificationMetastatic fociPathologic criteriaPulmonary sitesSecond primaryHistologic assessmentTumor boardCancer stagingLung tumors
2015
Gender, Age, and Comorbidity Status Predict Improved Survival with Adjuvant Chemotherapy Following Lobectomy for Non-small Cell Lung Cancers Larger than 4 cm
Sandler BJ, Wang Z, Hancock JG, Boffa DJ, Detterbeck FC, Kim AW. Gender, Age, and Comorbidity Status Predict Improved Survival with Adjuvant Chemotherapy Following Lobectomy for Non-small Cell Lung Cancers Larger than 4 cm. Annals Of Surgical Oncology 2015, 23: 638-645. PMID: 26474557, DOI: 10.1245/s10434-015-4902-8.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAge FactorsAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellChemotherapy, AdjuvantCohort StudiesCombined Modality TherapyComorbidityFemaleFollow-Up StudiesHumansLung NeoplasmsMaleMiddle AgedNeoplasm StagingPneumonectomyPrognosisSex FactorsSurvival RateYoung AdultConceptsNon-small cell lung cancerAdjuvant chemotherapyNational Cancer Data BaseNon-small cell lungCharlson-Deyo scorePretreatment prognostic factorsCell lung cancerCD scoresGroup of womenGroup of menConclusionsAdjuvant chemotherapySurvival benefitT2 tumorsPrognostic factorsDistant metastasisWomen 65Cell lungLung cancerNSCLC tumorsImproved outcomesChemotherapySurgeryPatientsWomenSurvivalViewing Lung Cancer in Color Instead of Black and White
Detterbeck FC. Viewing Lung Cancer in Color Instead of Black and White. Annals Of The American Thoracic Society 2015, 12: 1118-9. PMID: 26317270, DOI: 10.1513/annalsats.201506-338ed.Peer-Reviewed Original ResearchEvaluating the fate of patients who undergo resections of very large, node-negative lung cancers using the National Cancer DataBase
Liu J, Hancock JG, Moreno AC, Wang Z, Boffa DJ, Detterbeck FC, Kim AW. Evaluating the fate of patients who undergo resections of very large, node-negative lung cancers using the National Cancer DataBase. European Journal Of Cardio-Thoracic Surgery 2015, 49: 596-601. PMID: 25890936, DOI: 10.1093/ejcts/ezv139.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellChemoradiotherapy, AdjuvantDatabases, FactualFemaleFollow-Up StudiesHumansLung NeoplasmsLymph NodesMaleMiddle AgedNeoadjuvant TherapyNeoplasm StagingPneumonectomyRetrospective StudiesSurvival AnalysisTreatment OutcomeTumor BurdenUnited StatesConceptsPostoperative radiation therapyNational Cancer DatabaseNeoadjuvant chemoradiation therapyAdjuvant chemoradiation therapyChemoradiation therapyAdjuvant chemotherapyOverall survivalSurgical therapyLung cancerCancer DatabaseNode-negative lung cancerImproved OS relativeLymph node involvementKaplan-Meier methodCell lung cancerCox regression modelFate of patientsLog-rank testDifferent treatment modalitiesOS relativeNode involvementMetastatic diseaseSurgical resectionLymph nodesOS rates
2014
Transcervical Wedge Resection After Transcervical Extended Mediastinal Lymphadenectomy
Kim AW, Kull DR, Zieliski M, Boffa DJ, Detterbeck FC. Transcervical Wedge Resection After Transcervical Extended Mediastinal Lymphadenectomy. Innovations Technology And Techniques In Cardiothoracic And Vascular Surgery 2014, 9: 327-329. PMID: 25084246, DOI: 10.1097/imi.0000000000000079.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaFemaleHumansLung NeoplasmsLymph Node ExcisionMediastinumMiddle AgedNeckPneumonectomyConceptsSame anesthetic settingMediastinal lymphadenectomyWedge resectionM0 adenocarcinomaAnesthetic settingRight upper lobe wedge resectionTranscervical extended mediastinal lymphadenectomyAbsence of lymphPerioperative adverse eventsGround-glass opacitiesExtended mediastinal lymphadenectomyAtypical adenomatous hyperplasiaAdverse eventsLower lobectomyLung resectionCervical approachUpper lobeClinical stageGlass opacitiesLower lobeAdenomatous hyperplasiaPleural spaceResectionLymphadenectomyExcellent accessHow many names for a rose: Inconsistent classification of multiple foci of lung cancer due to ambiguous rules
Fonseca A, Detterbeck FC. How many names for a rose: Inconsistent classification of multiple foci of lung cancer due to ambiguous rules. Lung Cancer 2014, 85: 7-11. PMID: 24768582, DOI: 10.1016/j.lungcan.2014.02.014.Peer-Reviewed Original ResearchConceptsLung cancerPulmonary fociSeparate primary cancersOutcomes of patientsComparison of outcomesDifferent histologic typesMultifocal lung cancerSuch patientsHistologic typePrimary cancerPatient groupClinical scenariosPatientsCancerMultiple fociStage classificationMarked variabilityOutcomesInconsistent classificationCliniciansClearing Up Opacities
Detterbeck FC. Clearing Up Opacities. CHEST Journal 2014, 145: 9-10. PMID: 24394813, DOI: 10.1378/chest.13-1765.Peer-Reviewed Original Research
2013
Impact of preoperative radiation on survival of patients with T3N0 >7-cm non–small cell lung cancers treated with anatomic resection using the Surveillance, Epidemiology, and End Results database
Moreno AC, Morgensztern D, Yu JB, Boffa DJ, Decker RH, Detterbeck FC, Kim AW. Impact of preoperative radiation on survival of patients with T3N0 >7-cm non–small cell lung cancers treated with anatomic resection using the Surveillance, Epidemiology, and End Results database. Journal Of Surgical Research 2013, 184: 10-18. PMID: 23583079, DOI: 10.1016/j.jss.2013.03.053.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellFemaleFollow-Up StudiesHumansIncidenceKaplan-Meier EstimateLung NeoplasmsMaleMiddle AgedMultivariate AnalysisNeoadjuvant TherapyPneumonectomyPreoperative CareProportional Hazards ModelsSEER ProgramYoung AdultConceptsNon-small cell lung cancerLung cancer-specific survivalEnd Results (SEER) databaseNeoadjuvant radiationSurvival of patientsCell lung cancerResults databaseLung cancerLarge non-small cell lung cancersFive-year overallCancer-specific survivalEffect of surgeryKaplan-Meier methodCox regression modelLog-rank testCombination of chemotherapyLong-term survivalAnatomic resectionPreoperative radiationWorse OSTherapeutic challengeLarge tumorsPneumonectomyLobectomyPatients
2012
The Fable of Babel and Building a Foundation for Quality
Detterbeck FC. The Fable of Babel and Building a Foundation for Quality. Journal Of Thoracic Oncology 2012, 7: 267-268. PMID: 22252560, DOI: 10.1097/jto.0b013e318243262a.Peer-Reviewed Original Research
2011
Molecular classification of nonsmall cell lung cancer using a 4‐protein quantitative assay
Anagnostou VK, Dimou AT, Botsis T, Killiam EJ, Gustavson MD, Homer RJ, Boffa D, Zolota V, Dougenis D, Tanoue L, Gettinger SN, Detterbeck FC, Syrigos KN, Bepler G, Rimm DL. Molecular classification of nonsmall cell lung cancer using a 4‐protein quantitative assay. Cancer 2011, 118: 1607-1618. PMID: 22009766, DOI: 10.1002/cncr.26450.Peer-Reviewed Original ResearchSublobar Resection of Ground Glass Opacity—Great Data, but can I have More?
Detterbeck FC. Sublobar Resection of Ground Glass Opacity—Great Data, but can I have More? Journal Of Thoracic Oncology 2011, 6: 1451-1452. PMID: 21847067, DOI: 10.1097/jto.0b013e3182246429.Peer-Reviewed Original Research
2010
High expression of BCL-2 predicts favorable outcome in non-small cell lung cancer patients with non squamous histology
Anagnostou VK, Lowery FJ, Zolota V, Tzelepi V, Gopinath A, Liceaga C, Panagopoulos N, Frangia K, Tanoue L, Boffa D, Gettinger S, Detterbeck F, Homer RJ, Dougenis D, Rimm DL, Syrigos KN. High expression of BCL-2 predicts favorable outcome in non-small cell lung cancer patients with non squamous histology. BMC Cancer 2010, 10: 186. PMID: 20459695, PMCID: PMC2875218, DOI: 10.1186/1471-2407-10-186.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAgedBiomarkers, TumorCarcinoma, Large CellCarcinoma, Non-Small-Cell LungCarcinoma, Squamous CellCell DifferentiationCohort StudiesConnecticutFemaleGreeceHumansKaplan-Meier EstimateLung NeoplasmsMaleMiddle AgedNeoplasm StagingPredictive Value of TestsProportional Hazards ModelsProto-Oncogene Proteins c-bcl-2Reproducibility of ResultsRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUp-RegulationConceptsNon-small cell lung cancer patientsCell lung cancer patientsNon-squamous tumorsLung cancer patientsBcl-2 expressionNSCLC patientsCancer patientsBcl-2Favorable outcomeIndependent cohortSmall cell lung cancer patientsIndependent lower riskNon-squamous histologySubgroup of patientsHigh expressersSquamous cell carcinomaHigh Bcl-2 expressionBcl-2 protein levelsSquamous histologyMedian survivalPrognostic factorsValidation cohortCell carcinomaPathological characteristicsPrognostic stratification