2024
Anesthetic Risk with Large Mediastinal Masses: A Management Framework Based on a Systematic Review
Saffarzadeh A, Popescu W, Detterbeck F, Li A, Blasberg J. Anesthetic Risk with Large Mediastinal Masses: A Management Framework Based on a Systematic Review. The Annals Of Thoracic Surgery 2024 PMID: 39307215, DOI: 10.1016/j.athoracsur.2024.09.011.Peer-Reviewed Original ResearchMediastinal massSystematic reviewManagement of patientsVery-high-riskDegree of airwayDegree of symptomsAnatomic compressionRespiratory decompensationRetrospective seriesVascular compressionCase reportAnesthetic managementCategories of low-Anesthetic riskWriting panelIndividual patientsLow riskPubMed databaseDecompensationPatientsHigher-riskPotential decompensationAnesthesiaBack-up planReactive interventionsThe International Association for the Study of Lung Cancer Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groups in the Forthcoming (Ninth) Edition of the TNM Classification for Lung Cancer
Rami-Porta R, Nishimura K, Giroux D, Detterbeck F, Cardillo G, Edwards J, Fong K, Giuliani M, Huang J, Kernstine K, Marom E, Nicholson A, Van Schil P, Travis W, Tsao M, Watanabe S, Rusch V, Asamura H, Boards A. The International Association for the Study of Lung Cancer Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groups in the Forthcoming (Ninth) Edition of the TNM Classification for Lung Cancer. Journal Of Thoracic Oncology 2024, 19: 1007-1027. PMID: 38447919, DOI: 10.1016/j.jtho.2024.02.011.Peer-Reviewed Original ResearchClassification of lung cancerLung cancerTNM classificationStage groupSignificance of survival differencesInternational Association for the Study of Lung CancerLung Cancer Staging ProjectTNM stage groupingTNM classification of lung cancerStudy of Lung CancerEdition TNMStage NSCLCPathological stageClinical stageSurvival differencesAnatomic extentTNMSurvival analysisTreatment approachesCancerStatistical significanceMultivariate regressionPatientsLung
2021
Management of Stage III Non–Small-Cell Lung Cancer: ASCO Guideline
Daly ME, Singh N, Ismaila N, Antonoff MB, Arenberg DA, Bradley J, David E, Detterbeck F, Früh M, Gubens MA, Moore AC, Padda SK, Patel JD, Phillips T, Qin A, Robinson C, Simone CB. Management of Stage III Non–Small-Cell Lung Cancer: ASCO Guideline. Journal Of Clinical Oncology 2021, 40: 1356-1384. PMID: 34936470, DOI: 10.1200/jco.21.02528.Peer-Reviewed Original ResearchConceptsStage III NSCLCManagement of patientsCell lung cancerEvidence-based recommendationsLung cancerStage IIIEvidence-based guideline recommendationsUnresectable stage III NSCLCLiterature searchRecurrence-free survivalWorkup of patientsOutcomes of interestQuality of lifeAdvocacy expertsCommunity oncologyASCO guidelinesAdjuvant approachGuideline recommendationsSurgical managementMedical oncologyThoracic surgeryPulmonary oncologyExpert panel membersSystematic reviewPatientsInvasive thymoma – Which patients benefit from post-operative radiotherapy?
Muslim Z, Baig MZ, Weber JF, Detterbeck FC, Connery CP, Spera JA, Bhora FY. Invasive thymoma – Which patients benefit from post-operative radiotherapy? Asian Cardiovascular And Thoracic Annals 2021, 29: 935-942. PMID: 33975467, DOI: 10.1177/02184923211017094.Peer-Reviewed Original ResearchConceptsPost-operative radiotherapyWorld Health Organization histologyMasaoka-Koga stageStage III thymomaPropensity-matched cohortStage III diseaseClinical pathological factorsEnd Results (SEER) databasePositive prognostic indicatorUnderwent surgerySurgical treatmentThymoma patientsAdvanced thymomaB3 tumorsPrognostic implicationsResults databaseTumor sizeInvasive thymomaPrognostic indicatorSurvival differencesPatientsRadiotherapyThymomaSurgeryTumors
2019
Quality Versus Quantity
Chiu AS, Arnold BN, Hoag JR, Herrin J, Kim CH, Salazar MC, Monsalve AF, Jean RA, Blasberg JD, Detterbeck FC, Gross CP, Boffa DJ. Quality Versus Quantity. Annals Of Surgery 2019, Publish Ahead of Print: &na;. PMID: 29697446, DOI: 10.1097/sla.0000000000002762.Peer-Reviewed Original ResearchConceptsComplex cancer surgeryCancer surgerySafe hospitalComplex oncologic surgeryPotential mortality reductionNational Cancer DatabaseHigh-volume hospitalsHospital quality measuresSurgical mortalityPrimary cancerHospital rating systemsOncologic surgeryCancer DatabaseMortality reductionSurgical volumeHospital safetyPatient realignmentPatientsHospitalSurgeryMeaningful reductionPublic reportingMortalityRSMRCancerReport from the European Society of Thoracic Surgeons prospective thymic database 2017: a powerful resource for a collaborative global effort to manage thymic tumours
Ruffini E, Guerrera F, Brunelli A, Passani S, Pellicano D, Thomas P, Van Raemdonck D, Rocco G, Venuta F, Weder W, Detterbeck F, Falcoz PE. Report from the European Society of Thoracic Surgeons prospective thymic database 2017: a powerful resource for a collaborative global effort to manage thymic tumours. European Journal Of Cardio-Thoracic Surgery 2019, 55: 601-609. PMID: 30649256, DOI: 10.1093/ejcts/ezy448.Peer-Reviewed Original ResearchConceptsNeuroendocrine thymic tumoursThymic tumorsAdjuvant treatmentThymic carcinomaStage IStage IIIB tumorsEuropean SocietyStage IV tumorsOverall recurrence rateInvasive surgical approachNew International AssociationCollaborative global effortIIIB tumorsProspective databaseStage IIIAMetastasis classificationRecurrence rateGroup tumorsRare tumorSurgical approachRetrospective databaseInvasive techniquesStage IIIPatientsTumors
2018
Variable impact of prior cancer history on the survival of lung cancer patients
Monsalve AF, Hoag JR, Resio BJ, Chiu AS, Brown LB, Detterbeck FC, Blasberg JD, Boffa DJ. Variable impact of prior cancer history on the survival of lung cancer patients. Lung Cancer 2018, 127: 130-137. PMID: 30642541, DOI: 10.1016/j.lungcan.2018.11.040.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerPrior cancer historyNational Cancer DatabaseCancer historyOverall survivalNSCLC patientsMultivariable Cox proportional hazards regression modelsTreatment approachesCox proportional hazards regression modelProportional hazards regression modelsKaplan-Meier survival curvesNSCLC patient survivalCell lung cancerHazards regression modelsLung cancer patientsPrior cancerPrior malignancyNSCLC survivalPatient survivalCancer patientsLung cancerCancer DatabasePatient's potentialPrior historyPatientsIdentifying Drivers of Multiple Readmissions After Pulmonary Lobectomy
Jean RA, Chiu AS, Hoag JR, Blasberg JD, Boffa DJ, Detterbeck FC, Kim AW. Identifying Drivers of Multiple Readmissions After Pulmonary Lobectomy. The Annals Of Thoracic Surgery 2018, 107: 947-953. PMID: 30336117, DOI: 10.1016/j.athoracsur.2018.08.070.Peer-Reviewed Original ResearchConceptsPulmonary lobectomyMultiple readmissionsSecond readmissionFirst readmissionIndex hospitalizationPostoperative infectionLung cancerPrimary diagnosisHeart diseaseClinical Classification Software codesNationwide Readmissions DatabaseTime of readmissionPostoperative arrhythmiasPostoperative complicationsPostoperative sepsisPerioperative periodPostoperative periodClinical factorsReadmissionLobectomyPatientsStudy periodImportant markerDiagnosisHealthcare qualityRobotic-Assisted Lobectomies in the National Cancer Database
Arnold BN, Thomas DC, Narayan R, Blasberg JD, Detterbeck FC, Boffa DJ, Kim AW. Robotic-Assisted Lobectomies in the National Cancer Database. Journal Of The American College Of Surgeons 2018, 226: 1052-1062.e15. PMID: 29574177, DOI: 10.1016/j.jamcollsurg.2018.03.023.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseRobotic lobectomyLung cancerCancer DatabaseOutcomes of patientsPropensity-matched analysisThoracoscopic surgery lobectomyExperienced hospitalsOverall conversion ratePerioperative morbidityPrimary outcomePatient selectionAttendant sequelaeOpen procedureLobectomyAssisted LobectomyHigh mortalityHospitalPatientsMortalityIndividual hospitalsRate of conversionSignificant differencesYears of experienceOutcomesMultifocal adenocarcinoma: perspectives, assumptions and elephants
Detterbeck FC. Multifocal adenocarcinoma: perspectives, assumptions and elephants. Journal Of Thoracic Disease 2018, 10: 1193-1197. PMID: 29708150, PMCID: PMC5906316, DOI: 10.21037/jtd.2018.01.173.Peer-Reviewed Original ResearchPeeling back the onion: addressing nuances of CT screening for lung cancer
Detterbeck FC. Peeling back the onion: addressing nuances of CT screening for lung cancer. Journal Of Thoracic Disease 2018, 10: 585-588. PMID: 29608192, PMCID: PMC5864623, DOI: 10.21037/jtd.2018.01.73.Peer-Reviewed Original Research
2017
Positron Emission Tomography in Thymic Tumors: Analysis Using a Prospective Research Database
Korst RJ, Fernando S, Catlin AC, Rutledge JR, Girard N, Huang J, Detterbeck F, Database C. Positron Emission Tomography in Thymic Tumors: Analysis Using a Prospective Research Database. The Annals Of Thoracic Surgery 2017, 104: 1815-1820. PMID: 29033016, PMCID: PMC5785101, DOI: 10.1016/j.athoracsur.2017.06.053.Peer-Reviewed Original ResearchConceptsPositron emission tomographyInternational Thymic Malignancy Interest GroupHistologic typeThymic malignanciesPretreatment workupPathologic stageEmission tomographyProspective databaseThymic tumorsTumor stageMaximum standardized uptake valueProspective research databaseHistologic tumor typeThymic epithelial tumorsStandardized uptake valueCharacteristic curveAnalysis of receiverClinicopathologic featuresRare tumorEpithelial tumorsLarge cohortResearch DatabaseUptake valueTumor typesPatientsLength of Stay From the Hospital Perspective
Rosen JE, Salazar MC, Dharmarajan K, Kim AW, Detterbeck FC, Boffa DJ. Length of Stay From the Hospital Perspective. Annals Of Surgery 2017, 266: 383-388. PMID: 27564681, DOI: 10.1097/sla.0000000000001971.Peer-Reviewed Original ResearchConceptsMedian LOSLength of stayEarly discharge practicesDischarge practicesReadmission ratesEarly dischargeCancer-accredited hospitalsNational Cancer DatabaseLung cancer surgeryRisk of readmissionHospital discharge practicesHierarchical logistic regression modelsLack of effectLogistic regression modelsMore readmissionsUnplanned readmissionThoracotomy approachCancer surgeryReadmission riskLung cancerCancer DatabaseInclusion criteriaReadmissionHospital perspectivePatientsEffectiveness of local therapy for stage I non–small-cell lung cancer in nonagenarians
Arnold BN, Thomas DC, Rosen JE, Salazar MC, Detterbeck FC, Blasberg JD, Boffa DJ, Kim AW. Effectiveness of local therapy for stage I non–small-cell lung cancer in nonagenarians. Surgery 2017, 162: 640-651. PMID: 28697883, DOI: 10.1016/j.surg.2017.04.025.Peer-Reviewed Original ResearchMeSH KeywordsAged, 80 and overCarcinoma, Non-Small-Cell LungConfidence IntervalsDatabases, FactualDisease-Free SurvivalFemaleGeriatric AssessmentHumansKaplan-Meier EstimateLogistic ModelsLung NeoplasmsMaleMultivariate AnalysisNeoplasm InvasivenessNeoplasm StagingOdds RatioPneumonectomyProportional Hazards ModelsRadiotherapyRegistriesRisk AssessmentSecondary PreventionSurvival AnalysisConceptsCell lung cancerLocal therapyLung cancerStage IRelative survivalStereotactic body radiation therapyNational Cancer DatabaseBetter overall survivalBody radiation therapyOlder patientsOverall survivalPatient ageYounger patientsOverall mortalityPrimary outcomeCancer DatabaseTreatment outcomesTreatment decisionsRadiation therapyPatientsTherapyCancerNonagenariansTreatmentSurvival“What if I do nothing?” The natural history of operable cancer of the alimentary tract
Keshava HB, Rosen JE, DeLuzio MR, Kim AW, Detterbeck FC, Boffa DJ. “What if I do nothing?” The natural history of operable cancer of the alimentary tract. European Journal Of Surgical Oncology 2017, 43: 788-795. PMID: 28131669, DOI: 10.1016/j.ejso.2016.12.006.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAdultAgedAged, 80 and overCarcinoma, Signet Ring CellCarcinoma, Squamous CellColonic NeoplasmsDatabases, FactualDisease ProgressionEsophageal NeoplasmsFemaleGastrointestinal NeoplasmsHumansMaleMiddle AgedNeoplasm StagingRectal NeoplasmsStomach NeoplasmsSurvival RateUnited StatesWatchful WaitingConceptsAlimentary tract cancersTract cancerNatural historyUntreated patientsCancer surgeryClinical stage IStage-specific survivalOperable cancerInoperable patientsMedian survivalRectal cancerClinical stagePreoperative counselingPatientsStage ISurgeryCancerPoor healthAlimentary tractSurvivalHealth reasonsStudy objectiveTreatmentCIICIII
2016
The Eighth Edition Lung Cancer Stage Classification
Detterbeck FC, Boffa DJ, Kim AW, Tanoue LT. The Eighth Edition Lung Cancer Stage Classification. CHEST Journal 2016, 151: 193-203. PMID: 27780786, DOI: 10.1016/j.chest.2016.10.010.Peer-Reviewed Original ResearchConceptsLung cancer stage classificationCancer stage classificationCohort of patientsAnatomic extentContemporary patientsLung cancerClinical studiesStage classificationEighth editionSpecific patientPatientsInternal validationCancerStage classification systemMultiple assessmentsClassification systemCohortCliniciansThe IASLC Lung Cancer Staging Project: Methodology and Validation Used in the Development of Proposals for Revision of the Stage Classification of NSCLC in the Forthcoming (Eighth) Edition of the TNM Classification of Lung Cancer
Detterbeck FC, Chansky K, Groome P, Bolejack V, Crowley J, Shemanski L, Kennedy C, Krasnik M, Peake M, Rami-Porta R, Goldstraw P, Rami-Porta R, Asamura H, Ball D, Beer D, Beyruti R, Bolejack V, Chansky K, Crowley J, Detterbeck F, Eberhardt W, Edwards J, Galateau-Sallé F, Giroux D, Gleeson F, Groome P, Huang J, Kennedy C, Kim J, Kim Y, Kingsbury L, Kondo H, Krasnik M, Kubota K, Lerut A, Lyons G, Marino M, Marom E, van Meerbeeck J, Mitchell A, Nakano T, Nicholson A, Nowak A, Peake M, Rice T, Rosenzweig K, Ruffini E, Rusch V, Saijo N, Van Schil P, Sculier J, Shemanski L, Stratton K, Suzuki K, Tachimori Y, Thomas C, Travis W, Tsao M, Turrisi A, Vansteenkiste J, Watanabe H, Wu Y, Baas P, Erasmus J, Hasegawa S, Inai K, Kernstine K, Kindler H, Krug L, Nackaerts K, Pass H, Rice D, Falkson C, Filosso P, Giaccone G, Kondo K, Lucchi M, Okumura M, Blackstone E, Cavaco F, Barrera E, Arca J, Lamelas I, Obrer A, Jorge R, Ball D, Bascom G, Orozco A, Castro M, Blum M, Chimondeguy D, Cvijanovic V, Defranchi S, de Olaiz Navarro B, Campuzano I, Vidueira I, Araujo E, García F, Fong K, Corral G, González S, Gilart J, Arangüena L, Barajas S, Girard P, Goksel T, Budiño M, Casaurrán G, Blanco J, Hernández J, Rodríguez H, Collantes J, Heras M, Elena J, Jakobsen E, Kostas S, Atance P, Ares A, Liao M, Losanovscky M, Lyons G, Magaroles R, De Esteban Júlvez L, Gorospe M, McCaughan B, Kennedy C, Íñiguez R, Sorribes L, Gozalo S, de Arriba C, Delgado M, Alarcón J, Cuesta J, Park J, Pass H, Fernández M, Rosenberg M, Ruffini E, Rusch V, de Cos Escuín J, Vinuesa A, Mitjans M, Strand T, Subotic D, Swisher S, Terra R, Thomas C, Tournoy K, Van Schil P, Velasquez M, Wu Y, Yokoi K, Rami-Porta R, Ball D, Bolejack V, Crowley J, Giroux D, Kim J, Lyons G, Rice T, Suzuki K, Thomas C, Travis W, Wu Y, Asamura H, Ball D, Chansky K, Crowley J, Goldstraw P, Rusch V, van Schil P, Vansteenkiste J, Watanabe H, Wu Y, Zielinski M, Eberhardt W, Chansky K, Crowley J, Kim Y, Kondo H, Mitchell A, Turrisi A, Groome P, Detterbeck F, Bolejack V, Crowley J, Kennedy C, Krasnik M, Peake M, Sculier J, Chansky K, Crowley J, Giroux D, Gleeson F, van Meeerbeeck J, Travis W, Asamura H, Chansky K, Crowley J, Giroux D, Nicholson A, Beyruti R, Chansky K, Crowley J, Kubota K, Turrisi A, Tsao M, Beer D, Crowley J, Wu Y, Travis W, Asamura H, Bankier A, Beasley M, Detterbeck F, Flieder D, Goo J, MacMahon H, Naidich D, Nicholson A, Powell C, Prokop M, Rami-Porta R, Rusch V, van Schil P, Yatabe Y, Detterbeck F, Arenberg D, Asamura H, Bolejack V, Crowley J, Donington J, Franklin W, Girard N, Marom E, Mazzone P, Nicholson A, Rusch V, Tanoue L, Travis W. The IASLC Lung Cancer Staging Project: Methodology and Validation Used in the Development of Proposals for Revision of the Stage Classification of NSCLC in the Forthcoming (Eighth) Edition of the TNM Classification of Lung Cancer. Journal Of Thoracic Oncology 2016, 11: 1433-1446. PMID: 27448762, DOI: 10.1016/j.jtho.2016.06.028.Peer-Reviewed Original ResearchConceptsLung cancerLung cancer stage classificationIASLC Lung Cancer Staging ProjectLung Cancer Staging ProjectDifferent patient cohortsCancer stage classificationPrognostic Factors CommitteeAnatomic extentHistologic typeTNM classificationDefinition of tumorMetastasis classificationPatient cohortMetastasis categoryStage groupingEnough patientsStage classificationEighth editionCancerPatientsDiscriminatory abilityExternal validationTumorsInternational databasesEvidence of applicabilityLung Cancer in the Very Young: Treatment and Survival in the National Cancer Data Base
Arnold BN, Thomas DC, Rosen JE, Salazar MC, Blasberg JD, Boffa DJ, Detterbeck FC, Kim AW. Lung Cancer in the Very Young: Treatment and Survival in the National Cancer Data Base. Journal Of Thoracic Oncology 2016, 11: 1121-1131. PMID: 27103511, DOI: 10.1016/j.jtho.2016.03.023.Peer-Reviewed Original ResearchConceptsNon-small cell lung cancerNational Cancer Data BaseYounger patientsOlder patientsLung cancerRelative survivalStage IAdvanced stage non-small cell lung cancerCell lung cancerYears of ageAggressive therapyAggressive treatmentOverall survivalPatient demographicsPrimary outcomeTreatment patternsTumor characteristicsNSCLC casesPatientsStage IIIDetailed stagingSurvival informationOlder groupDistinct subsetsCancerA model for predicting prolonged length of stay in patients undergoing anatomical lung resection: a National Surgical Quality Improvement Program (NSQIP) database study
DeLuzio MR, Keshava HB, Wang Z, Boffa DJ, Detterbeck FC, Kim AW. A model for predicting prolonged length of stay in patients undergoing anatomical lung resection: a National Surgical Quality Improvement Program (NSQIP) database study. Interdisciplinary CardioVascular And Thoracic Surgery 2016, 23: 208-215. PMID: 27073262, DOI: 10.1093/icvts/ivw090.Peer-Reviewed Original ResearchConceptsAnatomical lung resectionProlonged lengthLung resectionRisk factorsRisk stratificationNational Surgical Quality Improvement Program database studyAnatomical pulmonary resectionBetter risk stratificationOverall patient outcomesHigh-risk populationLength of stayExternal validation groupLogistic regression analysisPostoperative complicationsPostoperative variablesPulmonary resectionNSQIP databaseComparison of receiverPatient outcomesDatabase studyResectionPatientsStayValidation groupScoring systemAdjuvant Chemotherapy for T3 Non–Small Cell Lung Cancer with Additional Tumor Nodules in the Same Lobe
Salazar MC, Rosen JE, Arnold BN, Thomas DC, Kim AW, Detterbeck FC, Blasberg JD, Boffa DJ. Adjuvant Chemotherapy for T3 Non–Small Cell Lung Cancer with Additional Tumor Nodules in the Same Lobe. Journal Of Thoracic Oncology 2016, 11: 1090-1100. PMID: 27013407, DOI: 10.1016/j.jtho.2016.03.009.Peer-Reviewed Original ResearchConceptsAdditional tumor nodulesAdjuvant chemotherapyT3 tumorsSame lobeTumor nodulesPostoperative chemotherapyOverall survivalSurgical resectionSurvival advantageNon-small cell lung cancerNational Cancer Data BaseNon-small cell lungAdditional pulmonary nodulesAdjuvant chemotherapy subgroupSurvival of patientsCell lung cancerSeparate tumor nodulesChemotherapy subgroupPrimary outcomeCell lungLung cancerChemotherapyCox modelRelative survivalPatients