Circulating Levels of the Interferon-γ-Regulated Chemokines CXCL10/CXCL11, IL-6 and HGF Predict Outcome in Metastatic Renal Cell Carcinoma Patients Treated with Antiangiogenic Therapy
Esteban E, Exposito F, Crespo G, Lambea J, Pinto A, Puente J, Arranz JA, Redrado M, Rodriguez-Antona C, de Andrea C, Lopez-Brea M, Redin E, Rodriguez A, Serrano D, Garcia J, Grande E, Castellano D, Calvo A. Circulating Levels of the Interferon-γ-Regulated Chemokines CXCL10/CXCL11, IL-6 and HGF Predict Outcome in Metastatic Renal Cell Carcinoma Patients Treated with Antiangiogenic Therapy. Cancers 2021, 13: 2849. PMID: 34200459, PMCID: PMC8201218, DOI: 10.3390/cancers13112849.Peer-Reviewed Original ResearchMetastatic renal cell carcinomaProgression-free survivalOverall survivalIL-6MRCC patientsSerum levelsTumor expressionAntiangiogenic therapyMetastatic renal cell carcinoma patientsMultivariable Cox regression analysisStandard first-line treatmentC-MetRenal cell carcinoma patientsShorter progression-free survivalFirst-line treatmentCell carcinoma patientsCohort of patientsHigh tumor expressionIL-6 levelsBasal serum levelsCox regression analysisHigh basal serum levelsLevels of biomarkersRenal cell carcinomaDifferent Spanish hospitals