2020
Bone Scans Have Little Utility in the Evaluation of Well-Differentiated Cartilaginous Lesions of the Humerus.
Samuel AM, Munger AM, Lee FY, Friedlaender GE, Ibe IK, Lindskog DM. Bone Scans Have Little Utility in the Evaluation of Well-Differentiated Cartilaginous Lesions of the Humerus. Orthopedics 2020, 43: e498-e502. PMID: 32882054, DOI: 10.3928/01477447-20200827-05.Peer-Reviewed Original ResearchConceptsRadionuclide bone scanBone scanMRI scansPositive findingsNegative findingsMagnetic resonance imaging (MRI) scansBone scan findingsProgression of lesionsResonance imaging scansDiagnosis of enchondromaAcademic medical centerBivariate logistic regressionAssociation of boneScan findingsAggressive featuresRadiographic findingsEndosteal scallopingBenign enchondromaImaging scansMedical recordsMedical CenterMalignant lesionsCartilaginous lesionsEnchondromaPatients
2009
siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells
Kim DW, Kim KO, Shin MJ, Ha JH, Seo SW, Yang J, Lee FY. siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells. Molecular Cancer 2009, 8: 28. PMID: 19445670, PMCID: PMC2689171, DOI: 10.1186/1476-4598-8-28.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsApoptosisATP Binding Cassette Transporter, Subfamily B, Member 1Bcl-X ProteinBone NeoplasmsCell Line, TumorChondrosarcomaDoxorubicinDrug Resistance, NeoplasmFlow CytometryGene SilencingGenes, bcl-2HumansImmunoblottingReverse Transcriptase Polymerase Chain ReactionRNA, Small InterferingX-Linked Inhibitor of Apoptosis ProteinConceptsAntiapoptotic proteinsChondrosarcoma cellsAntiapoptotic genesPharmacologic inhibitorsCell survival proteinsChondrosarcoma cell linesSurvival proteinsP-glycoproteinSiRNA knockdownCell typesProteinMechanisms of chemoresistanceCell linesGenesCommon mechanismChemoresistanceSiRNACellsP-glycoprotein inhibitionTherapeutic strategiesInhibitorsKnockdownApoptosisJJ012ConclusionThese findings
2007
Targeting of cell survival genes using small interfering RNAs (siRNAs) enhances radiosensitivity of Grade II chondrosarcoma cells
Kim DW, Seo SW, Cho SK, Chang SS, Lee HW, Lee E, Block JA, Hei TK, Lee FY. Targeting of cell survival genes using small interfering RNAs (siRNAs) enhances radiosensitivity of Grade II chondrosarcoma cells. Journal Of Orthopaedic Research® 2007, 25: 820-828. PMID: 17343283, DOI: 10.1002/jor.20377.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisApoptosis Regulatory ProteinsBcl-X ProteinBone NeoplasmsCell Line, TumorCell SurvivalChondrocytesChondrosarcomaGene Expression Regulation, NeoplasticHumansProto-Oncogene Proteins c-bcl-2Radiation ToleranceRNA, MessengerRNA, Small InterferingX-Linked Inhibitor of Apoptosis ProteinConceptsBcl-xLCell deathChondrosarcoma cellsGene silencingBcl-2Cell survival genesHuman chondrosarcoma cell lineClonogenic survival assaysChondrosarcoma cell linesNovel therapeutic conceptsCorresponding siRNAAntiapoptotic genesApoptotic pathwaySurvival genesAntiapoptotic mRNAsCell survivalXIAP geneMost chondrosarcomasAdjuvant therapySurgical resectionGenesSurvival assaysTherapeutic conceptsCell linesSilencing
2004
Diagnostic value and limitations of fluorine-18 fluorodeoxyglucose positron emission tomography for cartilaginous tumors of bone.
Lee FY, Yu J, Chang SS, Fawwaz R, Parisien MV. Diagnostic value and limitations of fluorine-18 fluorodeoxyglucose positron emission tomography for cartilaginous tumors of bone. Journal Of Bone And Joint Surgery 2004, 86: 2677-85. PMID: 15590853, DOI: 10.2106/00004623-200412000-00014.Peer-Reviewed Original ResearchConceptsHigh-grade chondrosarcomaPositron emission tomographyStandardized uptake valueStandard uptake valueCartilage tumorsGlucose metabolismGrade IIUptake valueCartilaginous tumorsEmission tomographyTumor sizeHistopathologic gradePredictive valueFluorine-18 fluorodeoxyglucose positron emission tomographyLow-grade cartilage tumorsMaximal standard uptake valueMaximal standardized uptake valueFluorodeoxyglucose positron emission tomographyHigh standard uptake valueBenign bone tumorsHigh glucose metabolismNegative predictive valueSignificant differencesMalignant cartilaginous tumorsPositive predictive value
2002
Novel translocation (9;12)(q22;q24) in secondardy chondrosarcoma arising from hereditary multiple exostosis
Lee FY, Zawadsky M, Parisien M, Ho M, Murty VV, Jayaraman T, Dick HM. Novel translocation (9;12)(q22;q24) in secondardy chondrosarcoma arising from hereditary multiple exostosis. Cancer Genetics 2002, 132: 68-70. PMID: 11801313, DOI: 10.1016/s0165-4608(01)00524-6.Peer-Reviewed Original Research
1999
Chondrosarcoma of bone: an assessment of outcome.
Lee FY, Mankin HJ, Fondren G, Gebhardt MC, Springfield DS, Rosenberg AE, Jennings LC. Chondrosarcoma of bone: an assessment of outcome. Journal Of Bone And Joint Surgery 1999, 81: 326-38. PMID: 10199270, DOI: 10.2106/00004623-199903000-00004.Peer-Reviewed Original ResearchConceptsGrade 3 lesionsIntralesional resectionLocal recurrenceHistological gradePostoperative adjuvant radiationLimb-sparing proceduresPredictor of metastasisGroup of patientsHigh-grade lesionsLow-grade tumorsPredictors of outcomeHigh-grade tumorsAssessment of outcomesAdjuvant radiationPathological fracturesRecurrent diseasePulmonary metastasesDistant metastasisAdjunctive chemotherapyMarginal resectionMean ageMean durationPelvic locationPrevalent siteGrade 3
1998
Reconstruction Of The Shoulder Joint Using An Acetabular Allograft
Lee FY, Hornicek FJ, Hazan EJ, Kloen P, Wolfe MA, Mankin HJ. Reconstruction Of The Shoulder Joint Using An Acetabular Allograft. Clinical Orthopaedics And Related Research® 1998, 357: 120-121. PMID: 9917707, DOI: 10.1097/00003086-199812000-00015.Peer-Reviewed Original ResearchConceptsShoulder jointAcetabular allograftWide resectionMusculoskeletal Tumor Society systemStable shoulder jointAggressive lesionsOsteoarticular allograftsAggressive tumorsCosmetic resultsFunctional resultsSurgical reconstructionAllograftsSecure reattachmentPatientsSoft tissueResectionCenter of motionSelect groupScapulaTumorsGlenoid regionJointsLesions
1994
Insulin-like Growth Factor I Regulation of Swarm Rat Chondrosarcoma Chondrocytes in Culture
Seong S, Matsumura T, Lee F, Whelan M, Li X, Trippel S. Insulin-like Growth Factor I Regulation of Swarm Rat Chondrosarcoma Chondrocytes in Culture. Experimental Cell Research 1994, 211: 238-244. PMID: 8143769, DOI: 10.1006/excr.1994.1083.Peer-Reviewed Original ResearchConceptsContribution of IGFDose-dependent fashionSwarm rat chondrosarcoma chondrocytesI antibodiesRat chondrosarcoma chondrocytesNonspecific antibodyFetal calf serumInsulin-like growth factor actionCalf serumInsulin-like growth factor IInsulin-like growth factor I regulationInhibitory effectChondrosarcoma chondrocytesRole of IGFIGF-I actionPresence of IGFEfficacy of IGFGrowth factor IMinimal inhibitory effectSerum-free controlsPost-natal lifeHalf-maximal stimulationEpiphyseal growth plateGrowth factor actionSerum concentrations