2011
Interleukin‐1β stimulates stromal‐derived factor‐1α expression in human subacromial bursa
Blaine TA, Cote MA, Proto A, Mulcahey M, Lee FY, Bigliani LU. Interleukin‐1β stimulates stromal‐derived factor‐1α expression in human subacromial bursa. Journal Of Orthopaedic Research® 2011, 29: 1695-1699. PMID: 21484857, DOI: 10.1002/jor.21416.Peer-Reviewed Original ResearchConceptsHuman subacromial bursaIL-1βIL-6SDF-1α expressionRotator cuff diseaseSubacromial bursaSubacromial bursitisSDF-1α productionSDF-1αCuff diseaseSDF-1α mRNA expressionBursal cellsInterleukin IL-1βSubacromial bursal tissueDose-dependent increaseFactor-1α expressionAnti-human antibodiesSupernatants of cellsRheumatoid controlsLocal cytokinesInflammatory cellsShoulder surgeryInterleukin-1βInflammatory responseIL-1
2006
Stromal cell‐derived factor 1 (SDF‐1, CXCL12) is increased in subacromial bursitis and downregulated by steroid and nonsteroidal anti‐inflammatory agents
Kim Y, Bigliani LU, Fujisawa M, Murakami K, Chang S, Lee H, Lee FY, Blaine TA. Stromal cell‐derived factor 1 (SDF‐1, CXCL12) is increased in subacromial bursitis and downregulated by steroid and nonsteroidal anti‐inflammatory agents. Journal Of Orthopaedic Research® 2006, 24: 1756-1764. PMID: 16779827, DOI: 10.1002/jor.20197.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalBursa, SynovialBursitisCells, CulturedChemokine CXCL12Chemokines, CXCCyclooxygenase 2 InhibitorsDexamethasoneDown-RegulationEnzyme-Linked Immunosorbent AssayHumansIn Vitro TechniquesMiddle AgedOligonucleotide Array Sequence AnalysisReverse Transcriptase Polymerase Chain ReactionRNA, MessengerRotator CuffTendinopathyConceptsReal-time reverse transcription-polymerase chain reactionSDF-1 proteinEnzyme-linked immunosorbent assayCOX-2 inhibitorsStromal cell-derived factor-1Cell-derived factor-1SDF-1 expressionSubacromial bursaSDF-1Subacromial bursitisReal-time RT-PCRBursal cellsBursal tissueNormal bone marrow stromal cellsNonsteroidal anti-inflammatory agentsSDF-1 expression levelsAnti-inflammatory medicationsUse of steroidsAnti-inflammatory agentsFactor 1Reverse transcription-polymerase chain reactionSubacromial bursal tissueRotator cuff diseaseTranscription-polymerase chain reactionSubacromial bursa tissue
2005
Zoledronate induces apoptosis in cells from fibro‐cellular membrane of unicameral bone cyst (UBC)
Yu J, Chang S, Suratwala S, Chung W, Abdelmessieh P, Lee H, Yang J, Lee F. Zoledronate induces apoptosis in cells from fibro‐cellular membrane of unicameral bone cyst (UBC). Journal Of Orthopaedic Research® 2005, 23: 1004-1012. PMID: 15921873, DOI: 10.1016/j.orthres.2005.02.012.Peer-Reviewed Original ResearchConceptsUnicameral bone cystsPeripheral blood mononuclear cellsBlood mononuclear cellsTrabecular bone cellsBone cystUBC cellsMononuclear cellsBone cellsZoledronate concentrationsIsolated peripheral blood mononuclear cellsImmunohisto/cytochemistryPercutaneous injection therapyAnti-resorptive agentsAnti-osteoclastogenic effectApoptotic fractionSTRO-1Potential therapeutic effectsPotential therapeutic roleEffect of zoledronateBenign cystic lesionsNitrogen-containing bisphosphonatesDose-dependent mannerOsteoclast-like cellsInjection therapyPathologic fractureRecruitment of osteoclast precursors by stromal cell derived factor‐1 (SDF‐1) in giant cell tumor of bone
Liao TS, Yurgelun MB, Chang S, Zhang H, Murakami K, Blaine TA, Parisian M, Kim W, Winchester RJ, Lee F. Recruitment of osteoclast precursors by stromal cell derived factor‐1 (SDF‐1) in giant cell tumor of bone. Journal Of Orthopaedic Research® 2005, 23: 203-209. PMID: 15607894, DOI: 10.1016/j.orthres.2004.06.018.Peer-Reviewed Original ResearchConceptsGiant cell tumorSDF-1Osteoclast precursorsStromal cellsCell tumorsSDF-1 gene expressionTumor-induced osteoclastogenesisSDF-1 proteinRecombinant SDF-1Neoplastic stromal cellsReal-time RT-PCRHematopoetic stem cellsOsteoclast precursor cellsTime RT-PCRBone lesionsStudy of osteoclastogenesisChemotactic concentrationsChemoattractant factorGCT tissuesMonocyte/Specific receptorsRT-PCRDisease modelsPrecursor cellsFactor 1