Harnessing endogenous stem/progenitor cells for tendon regeneration
Lee CH, Lee FY, Tarafder S, Kao K, Jun Y, Yang G, Mao JJ. Harnessing endogenous stem/progenitor cells for tendon regeneration. Journal Of Clinical Investigation 2015, 125: 2690-2701. PMID: 26053662, PMCID: PMC4563693, DOI: 10.1172/jci81589.Peer-Reviewed Original ResearchMeSH KeywordsAdult Stem CellsAnimalsCD146 AntigenCell DifferentiationCell ProliferationColony-Forming Units AssayConnective Tissue Growth FactorFocal Adhesion Kinase 1MAP Kinase Signaling SystemMultipotent Stem CellsRatsRats, Sprague-DawleyRegenerationTendon InjuriesTendonsTissue EngineeringWound HealingConceptsStem/progenitor cellsEndogenous stem/progenitor cellsProgenitor cellsCell transplantationTendon regenerationStem cell markers CD146Stem cell-based strategiesFAK/ERK1/2Cell-based strategiesRat modelTendon healingFunctional restorationNormal levelsMultilineage differentiation abilityClonogenic capacityCD146Tendon cellsSiRNA knockdownTransplantationVivo manipulation