siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells
Kim DW, Kim KO, Shin MJ, Ha JH, Seo SW, Yang J, Lee FY. siRNA-based targeting of antiapoptotic genes can reverse chemoresistance in P-glycoprotein expressing chondrosarcoma cells. Molecular Cancer 2009, 8: 28. PMID: 19445670, PMCID: PMC2689171, DOI: 10.1186/1476-4598-8-28.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsApoptosisATP Binding Cassette Transporter, Subfamily B, Member 1Bcl-X ProteinBone NeoplasmsCell Line, TumorChondrosarcomaDoxorubicinDrug Resistance, NeoplasmFlow CytometryGene SilencingGenes, bcl-2HumansImmunoblottingReverse Transcriptase Polymerase Chain ReactionRNA, Small InterferingX-Linked Inhibitor of Apoptosis ProteinConceptsAntiapoptotic proteinsChondrosarcoma cellsAntiapoptotic genesPharmacologic inhibitorsCell survival proteinsChondrosarcoma cell linesSurvival proteinsP-glycoproteinSiRNA knockdownCell typesProteinMechanisms of chemoresistanceCell linesGenesCommon mechanismChemoresistanceSiRNACellsP-glycoprotein inhibitionTherapeutic strategiesInhibitorsKnockdownApoptosisJJ012ConclusionThese findings