2017
Tendon stem/progenitor cells regulate inflammation in tendon healing via JNK and STAT3 signaling
Tarafder S, Chen E, Jun Y, Kao K, Sim KH, Back J, Lee FY, Lee CH. Tendon stem/progenitor cells regulate inflammation in tendon healing via JNK and STAT3 signaling. The FASEB Journal 2017, 31: 3991-3998. PMID: 28533328, PMCID: PMC5572690, DOI: 10.1096/fj.201700071r.Peer-Reviewed Original ResearchConceptsConnective tissue growth factorTendon stem/progenitor cellsIL-10 expressionStem/progenitor cellsIL-10TIMP-3 expressionTendon healingIL-1βProgenitor cellsTendon cellsElevated IL-10 expressionAnti-inflammatory IL-10Number of iNOSRat patellar tendonAnti-inflammatory roleAcute tendon injuryIL-6 expressionRegulation of inflammationTissue growth factorMMP-3 expressionNumber of CD146Improved tendon healingDifferent anatomic locationsWestern blot analysisPromising regenerative potential
2015
Harnessing endogenous stem/progenitor cells for tendon regeneration
Lee CH, Lee FY, Tarafder S, Kao K, Jun Y, Yang G, Mao JJ. Harnessing endogenous stem/progenitor cells for tendon regeneration. Journal Of Clinical Investigation 2015, 125: 2690-2701. PMID: 26053662, PMCID: PMC4563693, DOI: 10.1172/jci81589.Peer-Reviewed Original ResearchMeSH KeywordsAdult Stem CellsAnimalsCD146 AntigenCell DifferentiationCell ProliferationColony-Forming Units AssayConnective Tissue Growth FactorFocal Adhesion Kinase 1MAP Kinase Signaling SystemMultipotent Stem CellsRatsRats, Sprague-DawleyRegenerationTendon InjuriesTendonsTissue EngineeringWound HealingConceptsStem/progenitor cellsEndogenous stem/progenitor cellsProgenitor cellsCell transplantationTendon regenerationStem cell markers CD146Stem cell-based strategiesFAK/ERK1/2Cell-based strategiesRat modelTendon healingFunctional restorationNormal levelsMultilineage differentiation abilityClonogenic capacityCD146Tendon cellsSiRNA knockdownTransplantationVivo manipulation