2017
Additive manufacturing of hydrogel-based materials for next-generation implantable medical devices
Yin Chin S, Cheung Poh Y, Kohler AC, Compton JT, Hsu LL, Lau KM, Kim S, Lee BW, Lee FY, Sia SK. Additive manufacturing of hydrogel-based materials for next-generation implantable medical devices. Science Robotics 2017, 2 PMID: 31289767, PMCID: PMC6615760, DOI: 10.1126/scirobotics.aah6451.Peer-Reviewed Original ResearchNext-generation implantable medical devicesFast manufacturing methodSustained power supplyImplantable microdevicesImplantable medical devicesUnique mechanical propertiesTens of micronsAdditive manufacturingPrecise actuationMechanical propertiesPower supplyManufacturing methodsHydrogel componentsBiocompatible materialsLimited biocompatibilityMicrodevicesMedical devicesDiffusive propertiesDelivery of payloadsWide rangeBiocompatibilityLocking mechanismDevicesStatic componentMaterials
2013
Physiologic load-bearing characteristics of autografts, allografts, and polymer-based scaffolds in a critical sized segmental defect of long bone: an experimental study
Amorosa L, Lee C, Aydemir, Nizami S, Hsu A, Patel N, Gardner T, Navalgund A, Kim DG, Park S, Mao J, Lee F. Physiologic load-bearing characteristics of autografts, allografts, and polymer-based scaffolds in a critical sized segmental defect of long bone: an experimental study. International Journal Of Nanomedicine 2013, Volume 8: 1637-1643. PMID: 23637532, PMCID: PMC3639117, DOI: 10.2147/ijn.s42855.Peer-Reviewed Original ResearchConceptsAddition of hMSCsPolymer-based scaffoldsLoad-bearing characteristicsPhysiologic cyclic loadingPhase angleCritical-sized segmental defectsScaffold alone groupViscous stiffnessCyclic loadingMechanical propertiesFemoral defect modelSized segmental defectsRat femoral defect modelHuman mesenchymal stem cellsMechanical simulationsScaffold groupDifferent biomechanical characteristicsEnhanced bone formationHigh phase anglesDefect modelBiomechanical characteristicsExperimental studyHost boneStiffnessDefect repair
1997
Regional and temporal changes in the acoustic properties of fracture callus in secondary bone healing
Harten R, Lee F, Zimmerman M, Hurowitz E, Arakal R, Behrens F. Regional and temporal changes in the acoustic properties of fracture callus in secondary bone healing. Journal Of Orthopaedic Research® 1997, 15: 570-576. PMID: 9379267, DOI: 10.1002/jor.1100150413.Peer-Reviewed Original ResearchConceptsScanning acoustic microscopeMechanical propertiesAcoustic microscopyAcoustic microscopeMaterial propertiesAcoustic impedance mapsConventional testing methodsAcoustic propertiesImpedanceSecondary bone healingImpedance mapsTesting methodsPropertiesAccurate determinationBone healingPopular choiceFracturesLinear relationshipFracture healingDevicesPolymethylmethacrylateMicroscopeMean impedanceMaterials