2019
Bisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of Bone
Greenberg DD, Lee FY. Bisphosphonate-loaded Bone Cement as a Local Adjuvant Therapy for Giant Cell Tumor of Bone. American Journal Of Clinical Oncology 2019, 42: 231-237. PMID: 30811352, DOI: 10.1097/coc.0000000000000504.Peer-Reviewed Original ResearchConceptsGiant cell tumorAdjuvant therapyLocal adjuvant therapySystemic side effectsAvascular necrosisCell tumorsSide effectsMusculoskeletal Tumor Society scoreOsteoclast-like giant cellsAggressive bone resorptionTherapeutic Level IVHigh-speed burringLocal recurrence rateAtypical femur fracturesLevel of evidenceTraditional adjuvant therapyBone cementAtypical fracturesSystemic bisphosphonatesPulmonary metastasesSociety ScoreCurettage proceduresRecurrence rateFemur fracturesPolymethylmethacrylate bone cement
2004
Bisphosphonates May Reduce Recurrence in Giant Cell Tumor by Inducing Apoptosis
Chang SS, Suratwala SJ, Jung KM, Doppelt JD, Zhang HZ, Blaine TA, Kim TW, Winchester RJ, Lee FY. Bisphosphonates May Reduce Recurrence in Giant Cell Tumor by Inducing Apoptosis. Clinical Orthopaedics And Related Research® 2004, 426: 103-109. PMID: 15346059, DOI: 10.1097/01.blo.0000141372.54456.80.Peer-Reviewed Original ResearchConceptsGiant cell tumorCell tumorsAdjuvant therapyGiant cellsExogenous receptor activatorSpecific adjuvant therapyExtensive bone destructionTumor culturesLocal adjuvant therapyHigh recurrence rateNovel adjuvant therapyOsteoclastlike giant cellsNovel therapeutic agentsNF-kappaB ligandDose-dependent mannerBone destructionRecurrence rateAggressive tumorsBone resorptionSystemic useReceptor activatorAutocrine loopAutocrine mannerTumorsAutocrine regulation