Nuclear factor of activated T cells mediates fluid shear stress- and tensile strain-induced Cox2 in human and murine bone cells
Aydemir A, Minematsu H, Gardner TR, Kim KO, Ahn JM, Lee FY. Nuclear factor of activated T cells mediates fluid shear stress- and tensile strain-induced Cox2 in human and murine bone cells. Bone 2009, 46: 167-175. PMID: 19748606, PMCID: PMC2818272, DOI: 10.1016/j.bone.2009.08.061.Peer-Reviewed Original ResearchConceptsActivated T cellsT cellsBone cellsMechanical stimulationNuclear factorPathways of inflammationCytokine gene inductionMouse bone cellsMurine bone cellsBone massCOX2 inductionCOX2 expressionStability of implantsCalvarial bone cellsOsseous integrationHost boneNuclear translocationFluid shear stressDaily activitiesStimulationTranscription factorsNovel roleImplantsNFAT2Osteoblastic lineage