2010
Rapid generation of maturationally synchronized human dendritic cells: contribution to the clinical efficacy of extracorporeal photochemotherapy
Berger C, Hoffmann K, Vasquez JG, Mane S, Lewis J, Filler R, Lin A, Zhao H, Durazzo T, Baird A, Lin W, Foss F, Christensen I, Girardi M, Tigelaar R, Edelson R. Rapid generation of maturationally synchronized human dendritic cells: contribution to the clinical efficacy of extracorporeal photochemotherapy. Blood 2010, 116: 4838-4847. PMID: 20720185, PMCID: PMC3321745, DOI: 10.1182/blood-2009-11-256040.Peer-Reviewed Original ResearchMeSH KeywordsAntigen PresentationCell DifferentiationCell SeparationDendritic CellsFlow CytometryGene ExpressionGraft vs Host DiseaseHumansImmunophenotypingIn Situ HybridizationLymphoma, T-Cell, CutaneousMonocytesOligonucleotide Array Sequence AnalysisPhotopheresisReverse Transcriptase Polymerase Chain ReactionConceptsCutaneous T-cell lymphomaCostimulatory surface moleculesHuman dendritic cellsT-cell lymphomaDC differentiation pathwayAutoreactive disordersTherapeutic DCsDifferentiation pathwayHost diseaseDendritic cellsExtracorporeal photochemotherapyDistinctive molecular signaturesClinical efficacyOrgan rejectionCancer immunotherapyFunctional DCsEndogenous antigensNormal monocytesNormal subjectsClinical successCell differentiation pathwayLevel of expressionDisease statesMonocytesEnhanced expression
2006
Efficacy of low dose clofarabine in refractory precursor T- acute lymphoblastic leukemia.
Choi J, Foss F. Efficacy of low dose clofarabine in refractory precursor T- acute lymphoblastic leukemia. The Yale Journal Of Biology And Medicine 2006, 79: 169-72. PMID: 17940627, PMCID: PMC1994805.Peer-Reviewed Original ResearchMeSH KeywordsAdenine NucleotidesAdultArabinonucleosidesBone Marrow NeoplasmsClinical Trials as TopicClofarabineDrug Administration ScheduleDrug Resistance, NeoplasmHumansImmunophenotypingLeukemia-Lymphoma, Adult T-CellMaleRecurrenceSkin NeoplasmsStem Cell TransplantationTransplantation, HomologousTreatment OutcomeConceptsLow dose clofarabineLymphoblastic leukemiaAllogeneic stem cell transplantationSignificant clinical activityStem cell transplantationNear complete responseAcute lymphoblastic leukemiaPediatric B-ALLT-cell leukemiaAllogeneic transplantsComplete responsePoor prognosisCell transplantationB-ALLPrecursor TClinical activityNew agentsNovel nucleoside analogueClofarabinePatientsLeukemiaNucleoside analoguesSignificant activityRemissionTransplantation
2003
Peripheral T- cell lymphomas: diagnosis and management
Dearden CE, Foss FM. Peripheral T- cell lymphomas: diagnosis and management. Hematology/Oncology Clinics Of North America 2003, 17: 1351-1366. PMID: 14710889, DOI: 10.1016/s0889-8588(03)00119-9.Peer-Reviewed Original ResearchConceptsFirst-line therapyT-cell lymphomaCampath-1HResponse rateLine therapyPurine analoguesT-PLLAllogeneic bone marrow transplantationPeripheral T-cell lymphomaThird of patientsFavorable prognostic factorBone marrow transplantationMonoclonal antibody therapyStem cell transplantationNon-randomized studiesMature T-cell neoplasmsMinimal residual diseaseT-cell neoplasmsHigh response rateT-cell malignanciesLargest disease groupRisk of toxicityDurable remissionsRefractory patientsPreparative regimens
2002
Transformation in mycosis fungoides: The role of methotrexate
Abd-el-Baki J, Demierre MF, Li N, Foss FM. Transformation in mycosis fungoides: The role of methotrexate. Journal Of Cutaneous Medicine And Surgery 2002, 6: 109-116. PMID: 11992182, DOI: 10.1007/s10227-001-0040-y.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overCell Transformation, NeoplasticDermatologic AgentsFemaleGenes, T-Cell Receptor gammaHumansImmunophenotypingImmunosuppressive AgentsLymphoma, Large B-Cell, DiffuseMaleMethotrexateMiddle AgedMycosis FungoidesPolymerase Chain ReactionRetrospective StudiesSkin NeoplasmsSurvival AnalysisConceptsLarge cell lymphomaRole of methotrexateMycosis fungoidesCell lymphomaDominant T-cell cloneCutaneous lymphoma databaseT cell clonesIncidence of transformationLymphoma databaseImmunosuppressive therapyMTX groupMTX exposureShort followupMulticenter studyResultsA totalRisk factorsSkin biopsiesRare disorderHigh incidencePatientsAdvanced stageMethotrexateConclusionOur resultsSignificant associationSkin specimens